Population pharmacokinetic/pharmacodynamic modelling of the effects of axomadol and its O-demethyl metabolite on pupil diameter and nociception in healthy subjects.
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| Title: | Population pharmacokinetic/pharmacodynamic modelling of the effects of axomadol and its O-demethyl metabolite on pupil diameter and nociception in healthy subjects. |
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| Authors: | Mangas-Sanjuan V; Pharmacometrics and Systems Pharmacology, Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain.; Area of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University Miguel Hernández, Alicante, Spain., Pastor JM; Pharmacometrics and Systems Pharmacology, Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain., Rengelshausen J; Early Clinical Science, Grünenthal GmbH, Aachen, Germany., Bursi R; Pharmacometrics, Grünenthal GmbH, Aachen, Germany., Troconiz IF; Pharmacometrics and Systems Pharmacology, Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain.; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain. |
| Source: | British journal of clinical pharmacology [Br J Clin Pharmacol] 2016 Jul; Vol. 82 (1), pp. 92-107. Date of Electronic Publication: 2016 Apr 14. |
| Publication Type: | Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7503323 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2125 (Electronic) Linking ISSN: 03065251 NLM ISO Abbreviation: Br J Clin Pharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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