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A Phase 2A Trial of the Novel mGluR5-Negative Allosteric Modulator Dipraglurant for Levodopa-Induced Dyskinesia in Parkinson's Disease.

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Title: A Phase 2A Trial of the Novel mGluR5-Negative Allosteric Modulator Dipraglurant for Levodopa-Induced Dyskinesia in Parkinson's Disease.
Authors: Tison F; Université de Bordeaux, Institut des Maladies Neurodégénératives, Bordeaux, France. francois.tison@chu-bordeaux.fr.; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France. francois.tison@chu-bordeaux.fr.; Service de Neurologie, CHU de Bordeaux, Bordeaux, France. francois.tison@chu-bordeaux.fr.; NS-Park/FCRIN Network, UMS 015, Toulouse, France. francois.tison@chu-bordeaux.fr., Keywood C; Addex Pharma SA, Plan Les Ouates, Switzerland., Wakefield M; Addex Pharma SA, Plan Les Ouates, Switzerland., Durif F; NS-Park/FCRIN Network, UMS 015, Toulouse, France.; Neurology Service, A, Hôpital Gabriel Montpied, Clermont Ferrand, France., Corvol JC; NS-Park/FCRIN Network, UMS 015, Toulouse, France.; Sorbonne Universités and UPMC Univ Paris 06, INSERM UMRS-1127 and CIC-1422; CNRS UMR-7225; AP-HP; and ICM, Hôpital Pitié-Salpêtrière, Paris, France., Eggert K; Universitätsklinikum Giessen und Marburg, Klinik für Neurologie, Marburg, Germany., Lew M; Department of Neurology USC/Keck School of Medicine, Los Angeles, California, USA., Isaacson S; Parkinson's Disease and Movement Disorders Center of Boca Raton, Boca Raton, Florida, USA., Bezard E; Université de Bordeaux, Institut des Maladies Neurodégénératives, Bordeaux, France.; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France., Poli SM; Addex Pharma SA, Plan Les Ouates, Switzerland., Goetz CG; Rush University Medical Center, Dept. of Neurological Sciences, Movement Disorder Section, Chicago, Illinois, USA., Trenkwalder C; Paracelsus Elena Klinik, centre for Parkinson's Disease & Movement Disorders, Kassel, Germany., Rascol O; NS-Park/FCRIN Network, UMS 015, Toulouse, France.; CIC9302, Departments of Clinical Pharmacology and Neurosciences and NeuroToul COEN Center; INSERM, University Hospital of Toulouse and University of Toulouse 3, Toulouse, France.
Source: Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2016 Sep; Vol. 31 (9), pp. 1373-80. Date of Electronic Publication: 2016 May 23.
Publication Type: Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8610688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8257 (Electronic) Linking ISSN: 08853185 NLM ISO Abbreviation: Mov Disord Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A Phase 2A Trial of the Novel mGluR5-Negative Allosteric Modulator Dipraglurant for Levodopa-Induced Dyskinesia in Parkinson's Disease.
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  Data: <searchLink fieldCode="AU" term="%22Tison+F%22">Tison F</searchLink>; Université de Bordeaux, Institut des Maladies Neurodégénératives, Bordeaux, France. francois.tison@chu-bordeaux.fr.; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France. francois.tison@chu-bordeaux.fr.; Service de Neurologie, CHU de Bordeaux, Bordeaux, France. francois.tison@chu-bordeaux.fr.; NS-Park/FCRIN Network, UMS 015, Toulouse, France. francois.tison@chu-bordeaux.fr.<br /><searchLink fieldCode="AU" term="%22Keywood+C%22">Keywood C</searchLink>; Addex Pharma SA, Plan Les Ouates, Switzerland.<br /><searchLink fieldCode="AU" term="%22Wakefield+M%22">Wakefield M</searchLink>; Addex Pharma SA, Plan Les Ouates, Switzerland.<br /><searchLink fieldCode="AU" term="%22Durif+F%22">Durif F</searchLink>; NS-Park/FCRIN Network, UMS 015, Toulouse, France.; Neurology Service, A, Hôpital Gabriel Montpied, Clermont Ferrand, France.<br /><searchLink fieldCode="AU" term="%22Corvol+JC%22">Corvol JC</searchLink>; NS-Park/FCRIN Network, UMS 015, Toulouse, France.; Sorbonne Universités and UPMC Univ Paris 06, INSERM UMRS-1127 and CIC-1422; CNRS UMR-7225; AP-HP; and ICM, Hôpital Pitié-Salpêtrière, Paris, France.<br /><searchLink fieldCode="AU" term="%22Eggert+K%22">Eggert K</searchLink>; Universitätsklinikum Giessen und Marburg, Klinik für Neurologie, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Lew+M%22">Lew M</searchLink>; Department of Neurology USC/Keck School of Medicine, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Isaacson+S%22">Isaacson S</searchLink>; Parkinson's Disease and Movement Disorders Center of Boca Raton, Boca Raton, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Bezard+E%22">Bezard E</searchLink>; Université de Bordeaux, Institut des Maladies Neurodégénératives, Bordeaux, France.; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Poli+SM%22">Poli SM</searchLink>; Addex Pharma SA, Plan Les Ouates, Switzerland.<br /><searchLink fieldCode="AU" term="%22Goetz+CG%22">Goetz CG</searchLink>; Rush University Medical Center, Dept. of Neurological Sciences, Movement Disorder Section, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Trenkwalder+C%22">Trenkwalder C</searchLink>; Paracelsus Elena Klinik, centre for Parkinson's Disease & Movement Disorders, Kassel, Germany.<br /><searchLink fieldCode="AU" term="%22Rascol+O%22">Rascol O</searchLink>; NS-Park/FCRIN Network, UMS 015, Toulouse, France.; CIC9302, Departments of Clinical Pharmacology and Neurosciences and NeuroToul COEN Center; INSERM, University Hospital of Toulouse and University of Toulouse 3, Toulouse, France.
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  Data: <searchLink fieldCode="JN" term="%228610688%22">Movement disorders : official journal of the Movement Disorder Society</searchLink> [Mov Disord] 2016 Sep; Vol. 31 (9), pp. 1373-80. <i>Date of Electronic Publication: </i>2016 May 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley-Liss%22">Wiley-Liss </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8610688 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1531-8257 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208853185%22">08853185 </searchLink><i>NLM ISO Abbreviation: </i>Mov Disord <i>Subsets: </i>MEDLINE
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