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Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor.

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Title: Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor.
Authors: Martínez-Hoyos M; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Perez-Herran E; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Gulten G; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA., Encinas L; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Álvarez-Gómez D; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Alvarez E; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Ferrer-Bazaga S; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., García-Pérez A; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Ortega F; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Angulo-Barturen I; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Rullas-Trincado J; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Blanco Ruano D; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Torres P; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Castañeda P; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Huss S; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Fernández Menéndez R; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., González Del Valle S; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Ballell L; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Barros D; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Modha S; Target and Pathway Validation, Molecular Discovery Research, GlaxoSmithKline, Stevenage, Herts, UK., Dhar N; School of Life Sciences, Swiss Federal Institute of Technology in Lausanne (EPFL), Lausanne 1015, Switzerland., Signorino-Gelo F; Target and Pathway Validation, Molecular Discovery Research, GlaxoSmithKline, Stevenage, Herts, UK., McKinney JD; Target and Pathway Validation, Molecular Discovery Research, GlaxoSmithKline, Stevenage, Herts, UK., García-Bustos JF; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Lavandera JL; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Sacchettini JC; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA., Jimenez MS; ISCIII, Crta. Majadahonda-Pozuelo Km 2, Majadahonda 28220, Madrid., Martín-Casabona N; Department of Microbiology Vall d'Hebron Hospital, Autonomous University Barcelona, Barcelona, Spain., Castro-Pichel J; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Mendoza-Losana A; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain. Electronic address: alfonso.x.mendoza@gsk.com.
Source: EBioMedicine [EBioMedicine] 2016 Jun; Vol. 8, pp. 291-301. Date of Electronic Publication: 2016 May 08.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Martínez-Hoyos+M%22">Martínez-Hoyos M</searchLink>; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Perez-Herran+E%22">Perez-Herran E</searchLink>; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Gulten+G%22">Gulten G</searchLink>; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA.<br /><searchLink fieldCode="AU" term="%22Encinas+L%22">Encinas L</searchLink>; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Álvarez-Gómez+D%22">Álvarez-Gómez D</searchLink>; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Alvarez+E%22">Alvarez E</searchLink>; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Ferrer-Bazaga+S%22">Ferrer-Bazaga S</searchLink>; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22García-Pérez+A%22">García-Pérez A</searchLink>; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Ortega+F%22">Ortega F</searchLink>; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Angulo-Barturen+I%22">Angulo-Barturen I</searchLink>; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Rullas-Trincado+J%22">Rullas-Trincado J</searchLink>; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Blanco+Ruano+D%22">Blanco Ruano D</searchLink>; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Torres+P%22">Torres P</searchLink>; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Castañeda+P%22">Castañeda P</searchLink>; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Huss+S%22">Huss S</searchLink>; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Fernández+Menéndez+R%22">Fernández Menéndez R</searchLink>; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22González+Del+Valle+S%22">González Del Valle S</searchLink>; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Ballell+L%22">Ballell L</searchLink>; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Barros+D%22">Barros D</searchLink>; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Modha+S%22">Modha S</searchLink>; Target and Pathway Validation, Molecular Discovery Research, GlaxoSmithKline, Stevenage, Herts, UK.<br /><searchLink fieldCode="AU" term="%22Dhar+N%22">Dhar N</searchLink>; School of Life Sciences, Swiss Federal Institute of Technology in Lausanne (EPFL), Lausanne 1015, Switzerland.<br /><searchLink fieldCode="AU" term="%22Signorino-Gelo+F%22">Signorino-Gelo F</searchLink>; Target and Pathway Validation, Molecular Discovery Research, GlaxoSmithKline, Stevenage, Herts, UK.<br /><searchLink fieldCode="AU" term="%22McKinney+JD%22">McKinney JD</searchLink>; Target and Pathway Validation, Molecular Discovery Research, GlaxoSmithKline, Stevenage, Herts, UK.<br /><searchLink fieldCode="AU" term="%22García-Bustos+JF%22">García-Bustos JF</searchLink>; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Lavandera+JL%22">Lavandera JL</searchLink>; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Sacchettini+JC%22">Sacchettini JC</searchLink>; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA.<br /><searchLink fieldCode="AU" term="%22Jimenez+MS%22">Jimenez MS</searchLink>; ISCIII, Crta. Majadahonda-Pozuelo Km 2, Majadahonda 28220, Madrid.<br /><searchLink fieldCode="AU" term="%22Martín-Casabona+N%22">Martín-Casabona N</searchLink>; Department of Microbiology Vall d'Hebron Hospital, Autonomous University Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Castro-Pichel+J%22">Castro-Pichel J</searchLink>; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Mendoza-Losana+A%22">Mendoza-Losana A</searchLink>; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain. Electronic address: alfonso.x.mendoza@gsk.com.
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