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Genome-wide association study with additional genetic and post-transcriptional analyses reveals novel regulators of plasma factor XI levels.

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Title: Genome-wide association study with additional genetic and post-transcriptional analyses reveals novel regulators of plasma factor XI levels.
Authors: Sennblad B; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.; Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Sweden., Basu S; University of Minnesota School of Public Health, Division of Biostatistics, MN, USA., Mazur J; University Medical Center Mainz, Johannes Gutenberg University Mainz, Mainz, Germany., Suchon P; Institut National pour la Santé et la Recherche Médicale (INSERM), Unité Mixte de Recherche en Santé (UMR_S) 1062, Nutrition Obesity and Risk of Thrombosis, Marseille, France; Aix-Marseille University., Martinez-Perez A; Unitat de Genòmica de Malalties Complexes. Institut d'Investigació Biomèdica Sant Pau (IIB-Sant Pau), Barcelona, Spain., van Hylckama Vlieg A; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Truong V; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada., Li Y; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden., Gådin JR; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden., Tang W; University of Minnesota School of Public Health, Division of Epidemiology and Community Health, Minneapolis, MN, USA., Grossman V; University Medical Center Mainz, Johannes Gutenberg University Mainz, Mainz, Germany., de Haan HG; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Handin N; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden., Silveira A; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden., Souto JC; Unitat de Trombosi i Hemostàsia, Hospital de Sant Pau, Barcelona, Spain., Franco-Cereceda A; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Morange PE; Institut National pour la Santé et la Recherche Médicale (INSERM), Unité Mixte de Recherche en Santé (UMR_S) 1062, Nutrition Obesity and Risk of Thrombosis, Marseille, France; Aix-Marseille University., Gagnon F; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada., Soria JM; Unitat de Genòmica de Malalties Complexes. Institut d'Investigació Biomèdica Sant Pau (IIB-Sant Pau), Barcelona, Spain., Eriksson P; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden., Hamsten A; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden., Maegdefessel L; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden., Rosendaal FR; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Wild P; University Medical Center Mainz, Johannes Gutenberg University Mainz, Mainz, Germany.; Preventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.; DZHK (German Center for Cardiovascular Research), partner site RhineMain, Mainz, Germany., Folsom AR; University of Minnesota School of Public Health, Division of Epidemiology and Community Health, Minneapolis, MN, USA., Trégouët DA; Sorbonne Universités, UPMC Univ. Paris 06, INSERM, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris, France.; ICAN Institute for Cardiometabolism and Nutrition, Paris, France., Sabater-Lleal M; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Source: Human molecular genetics [Hum Mol Genet] 2017 Feb 01; Vol. 26 (3), pp. 637-649.
Publication Type: Journal Article
Journal Info: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE
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  Data: Genome-wide association study with additional genetic and post-transcriptional analyses reveals novel regulators of plasma factor XI levels.
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  Data: <searchLink fieldCode="AU" term="%22Sennblad+B%22">Sennblad B</searchLink>; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.; Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Sweden.<br /><searchLink fieldCode="AU" term="%22Basu+S%22">Basu S</searchLink>; University of Minnesota School of Public Health, Division of Biostatistics, MN, USA.<br /><searchLink fieldCode="AU" term="%22Mazur+J%22">Mazur J</searchLink>; University Medical Center Mainz, Johannes Gutenberg University Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Suchon+P%22">Suchon P</searchLink>; Institut National pour la Santé et la Recherche Médicale (INSERM), Unité Mixte de Recherche en Santé (UMR_S) 1062, Nutrition Obesity and Risk of Thrombosis, Marseille, France; Aix-Marseille University.<br /><searchLink fieldCode="AU" term="%22Martinez-Perez+A%22">Martinez-Perez A</searchLink>; Unitat de Genòmica de Malalties Complexes. Institut d'Investigació Biomèdica Sant Pau (IIB-Sant Pau), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22van+Hylckama+Vlieg+A%22">van Hylckama Vlieg A</searchLink>; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Truong+V%22">Truong V</searchLink>; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Gådin+JR%22">Gådin JR</searchLink>; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Tang+W%22">Tang W</searchLink>; University of Minnesota School of Public Health, Division of Epidemiology and Community Health, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Grossman+V%22">Grossman V</searchLink>; University Medical Center Mainz, Johannes Gutenberg University Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22de+Haan+HG%22">de Haan HG</searchLink>; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Handin+N%22">Handin N</searchLink>; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Silveira+A%22">Silveira A</searchLink>; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Souto+JC%22">Souto JC</searchLink>; Unitat de Trombosi i Hemostàsia, Hospital de Sant Pau, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Franco-Cereceda+A%22">Franco-Cereceda A</searchLink>; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Morange+PE%22">Morange PE</searchLink>; Institut National pour la Santé et la Recherche Médicale (INSERM), Unité Mixte de Recherche en Santé (UMR_S) 1062, Nutrition Obesity and Risk of Thrombosis, Marseille, France; Aix-Marseille University.<br /><searchLink fieldCode="AU" term="%22Gagnon+F%22">Gagnon F</searchLink>; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Soria+JM%22">Soria JM</searchLink>; Unitat de Genòmica de Malalties Complexes. Institut d'Investigació Biomèdica Sant Pau (IIB-Sant Pau), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Eriksson+P%22">Eriksson P</searchLink>; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Hamsten+A%22">Hamsten A</searchLink>; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Maegdefessel+L%22">Maegdefessel L</searchLink>; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Rosendaal+FR%22">Rosendaal FR</searchLink>; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Wild+P%22">Wild P</searchLink>; University Medical Center Mainz, Johannes Gutenberg University Mainz, Mainz, Germany.; Preventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.; DZHK (German Center for Cardiovascular Research), partner site RhineMain, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Folsom+AR%22">Folsom AR</searchLink>; University of Minnesota School of Public Health, Division of Epidemiology and Community Health, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Trégouët+DA%22">Trégouët DA</searchLink>; Sorbonne Universités, UPMC Univ. Paris 06, INSERM, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris, France.; ICAN Institute for Cardiometabolism and Nutrition, Paris, France.<br /><searchLink fieldCode="AU" term="%22Sabater-Lleal+M%22">Sabater-Lleal M</searchLink>; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
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