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Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell-associated damage in IFNα-driven lupus nephritis.

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Title: Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell-associated damage in IFNα-driven lupus nephritis.
Authors: Katewa A; Departments of Immunology Discovery., Wang Y; Departments of Immunology Discovery., Hackney JA; Bioinformatics and Computational Biology., Huang T; Departments of Immunology Discovery., Suto E; Translational Immunology., Ramamoorthi N; Biomarker Discovery OMNI., Austin CD; Pathology., Bremer M; Biomarker Development., Chen JZ; Drug Metabolism and Pharmacokinetics., Crawford JJ; Discovery Chemistry, at Genentech, South San Francisco, California, USA., Currie KS; Gilead Sciences, Seattle, Washington, USA., Blomgren P; Gilead Sciences, Seattle, Washington, USA., DeVoss J; Translational Immunology., DiPaolo JA; Gilead Sciences, Foster City, California, USA., Hau J; Small Molecule Pharmaceutical Sciences., Johnson A; Biochemical and Cellular Pharmacology., Lesch J; Translational Immunology., DeForge LE; Biochemical and Cellular Pharmacology., Lin Z; Translational Immunology., Liimatta M; Biochemical and Cellular Pharmacology., Lubach JW; Small Molecule Pharmaceutical Sciences., McVay S; Biochemical and Cellular Pharmacology., Modrusan Z; Molecular Biology., Nguyen A; Biochemical and Cellular Pharmacology., Poon C; Departments of Immunology Discovery., Wang J; Biochemical and Cellular Pharmacology., Liu L; Clinical Pharmacology at Genentech, South San Francisco, California, USA., Lee WP; Translational Immunology., Wong H; Drug Metabolism and Pharmacokinetics., Young WB; Discovery Chemistry, at Genentech, South San Francisco, California, USA., Townsend MJ; Biomarker Discovery OMNI., Reif K; Departments of Immunology Discovery.
Source: JCI insight [JCI Insight] 2017 Apr 06; Vol. 2 (7), pp. e90111. Date of Electronic Publication: 2017 Apr 06.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell-associated damage in IFNα-driven lupus nephritis.
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  Data: <searchLink fieldCode="AU" term="%22Katewa+A%22">Katewa A</searchLink>; Departments of Immunology Discovery.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Departments of Immunology Discovery.<br /><searchLink fieldCode="AU" term="%22Hackney+JA%22">Hackney JA</searchLink>; Bioinformatics and Computational Biology.<br /><searchLink fieldCode="AU" term="%22Huang+T%22">Huang T</searchLink>; Departments of Immunology Discovery.<br /><searchLink fieldCode="AU" term="%22Suto+E%22">Suto E</searchLink>; Translational Immunology.<br /><searchLink fieldCode="AU" term="%22Ramamoorthi+N%22">Ramamoorthi N</searchLink>; Biomarker Discovery OMNI.<br /><searchLink fieldCode="AU" term="%22Austin+CD%22">Austin CD</searchLink>; Pathology.<br /><searchLink fieldCode="AU" term="%22Bremer+M%22">Bremer M</searchLink>; Biomarker Development.<br /><searchLink fieldCode="AU" term="%22Chen+JZ%22">Chen JZ</searchLink>; Drug Metabolism and Pharmacokinetics.<br /><searchLink fieldCode="AU" term="%22Crawford+JJ%22">Crawford JJ</searchLink>; Discovery Chemistry, at Genentech, South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Currie+KS%22">Currie KS</searchLink>; Gilead Sciences, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Blomgren+P%22">Blomgren P</searchLink>; Gilead Sciences, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22DeVoss+J%22">DeVoss J</searchLink>; Translational Immunology.<br /><searchLink fieldCode="AU" term="%22DiPaolo+JA%22">DiPaolo JA</searchLink>; Gilead Sciences, Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Hau+J%22">Hau J</searchLink>; Small Molecule Pharmaceutical Sciences.<br /><searchLink fieldCode="AU" term="%22Johnson+A%22">Johnson A</searchLink>; Biochemical and Cellular Pharmacology.<br /><searchLink fieldCode="AU" term="%22Lesch+J%22">Lesch J</searchLink>; Translational Immunology.<br /><searchLink fieldCode="AU" term="%22DeForge+LE%22">DeForge LE</searchLink>; Biochemical and Cellular Pharmacology.<br /><searchLink fieldCode="AU" term="%22Lin+Z%22">Lin Z</searchLink>; Translational Immunology.<br /><searchLink fieldCode="AU" term="%22Liimatta+M%22">Liimatta M</searchLink>; Biochemical and Cellular Pharmacology.<br /><searchLink fieldCode="AU" term="%22Lubach+JW%22">Lubach JW</searchLink>; Small Molecule Pharmaceutical Sciences.<br /><searchLink fieldCode="AU" term="%22McVay+S%22">McVay S</searchLink>; Biochemical and Cellular Pharmacology.<br /><searchLink fieldCode="AU" term="%22Modrusan+Z%22">Modrusan Z</searchLink>; Molecular Biology.<br /><searchLink fieldCode="AU" term="%22Nguyen+A%22">Nguyen A</searchLink>; Biochemical and Cellular Pharmacology.<br /><searchLink fieldCode="AU" term="%22Poon+C%22">Poon C</searchLink>; Departments of Immunology Discovery.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Biochemical and Cellular Pharmacology.<br /><searchLink fieldCode="AU" term="%22Liu+L%22">Liu L</searchLink>; Clinical Pharmacology at Genentech, South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Lee+WP%22">Lee WP</searchLink>; Translational Immunology.<br /><searchLink fieldCode="AU" term="%22Wong+H%22">Wong H</searchLink>; Drug Metabolism and Pharmacokinetics.<br /><searchLink fieldCode="AU" term="%22Young+WB%22">Young WB</searchLink>; Discovery Chemistry, at Genentech, South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Townsend+MJ%22">Townsend MJ</searchLink>; Biomarker Discovery OMNI.<br /><searchLink fieldCode="AU" term="%22Reif+K%22">Reif K</searchLink>; Departments of Immunology Discovery.
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  Data: <searchLink fieldCode="JN" term="%22101676073%22">JCI insight</searchLink> [JCI Insight] 2017 Apr 06; Vol. 2 (7), pp. e90111. <i>Date of Electronic Publication: </i>2017 Apr 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Clinical+Investigation%22">American Society for Clinical Investigation </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101676073 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2379-3708 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223793708%22">23793708 </searchLink><i>NLM ISO Abbreviation: </i>JCI Insight <i>Subsets: </i>MEDLINE
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