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Genomic profiling of ER+ breast cancers after short-term estrogen suppression reveals alterations associated with endocrine resistance.

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Title: Genomic profiling of ER+ breast cancers after short-term estrogen suppression reveals alterations associated with endocrine resistance.
Authors: Giltnane JM; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Hutchinson KE; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Stricker TP; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Formisano L; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Young CD; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Estrada MV; Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Nixon MJ; Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Du L; Vanderbilt Center for Quantitative Sciences, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Sanchez V; Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Ericsson PG; Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Kuba MG; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Sanders ME; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Mu XJ; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Van Allen EM; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Wagle N; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Mayer IA; Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Abramson V; Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Gόmez H; Instituto Nacional de Enfermedades Neoplásicas, Surquillo 15038, Peru., Rizzo M; Department of Surgery, Emory University, Atlanta, GA 30322, USA., Toy W; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10022, USA., Chandarlapaty S; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10022, USA., Mayer EL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Christiansen J; Genoptix Medical Laboratories, Carlsbad, CA 92008, USA., Murphy D; Genoptix Medical Laboratories, Carlsbad, CA 92008, USA., Fitzgerald K; Genoptix Medical Laboratories, Carlsbad, CA 92008, USA., Wang K; Foundation Medicine Inc., Cambridge, MA 02141, USA., Ross JS; Foundation Medicine Inc., Cambridge, MA 02141, USA.; Department of Pathology, Albany Medical College, Albany, NY 12208, USA., Miller VA; Foundation Medicine Inc., Cambridge, MA 02141, USA., Stephens PJ; Foundation Medicine Inc., Cambridge, MA 02141, USA., Yelensky R; Foundation Medicine Inc., Cambridge, MA 02141, USA., Garraway L; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Joint Center for Cancer Precision Medicine, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Shyr Y; Vanderbilt Center for Quantitative Sciences, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Meszoely I; Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Balko JM; Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Arteaga CL; Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA. carlos.arteaga@vanderbilt.edu.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Source: Science translational medicine [Sci Transl Med] 2017 Aug 09; Vol. 9 (402).
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: Genomic profiling of ER<superscript>+</superscript> breast cancers after short-term estrogen suppression reveals alterations associated with endocrine resistance.
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