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ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways.

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Title: ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways.
Authors: Le TM; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Ahmanson Translational Imaging Division, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Poddar S; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Ahmanson Translational Imaging Division, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Capri JR; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Ahmanson Translational Imaging Division, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Abt ER; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Ahmanson Translational Imaging Division, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Kim W; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Ahmanson Translational Imaging Division, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Wei L; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Ahmanson Translational Imaging Division, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Uong NT; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Ahmanson Translational Imaging Division, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Cheng CM; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Ahmanson Translational Imaging Division, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Braas D; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; UCLA Metabolomic Center, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Nikanjam M; Division of Hematology-Oncology, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Rix P; Vector Pharma Advisors Inc., San Diego, CA, 92130, USA., Merkurjev D; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Zaretsky J; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Kornblum HI; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Ribas A; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Division of Hematology-Oncology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Department of Surgery, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Department of Medicine, Division of Surgical Oncology, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Herschman HR; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Ahmanson Translational Imaging Division, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Whitelegge J; The Pasarow Mass Spectrometry Laboratory, Neuropsychiatric Institute-Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Faull KF; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Ahmanson Translational Imaging Division, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; The Pasarow Mass Spectrometry Laboratory, Neuropsychiatric Institute-Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Donahue TR; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Ahmanson Translational Imaging Division, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Department of Surgery, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Czernin J; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Ahmanson Translational Imaging Division, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Radu CG; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, 90095, USA. cradu@mednet.ucla.edu.; Ahmanson Translational Imaging Division, University of California, Los Angeles, Los Angeles, CA, 90095, USA. cradu@mednet.ucla.edu.
Source: Nature communications [Nat Commun] 2017 Aug 14; Vol. 8 (1), pp. 241. Date of Electronic Publication: 2017 Aug 14.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways.
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  Data: <searchLink fieldCode="AU" term="%22Le+TM%22">Le TM</searchLink>; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Ahmanson Translational Imaging Division, University of California, Los Angeles, Los Angeles, CA, 90095, USA.<br /><searchLink fieldCode="AU" term="%22Poddar+S%22">Poddar S</searchLink>; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Ahmanson Translational Imaging Division, University of California, Los Angeles, Los Angeles, CA, 90095, USA.<br /><searchLink fieldCode="AU" term="%22Capri+JR%22">Capri JR</searchLink>; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Ahmanson Translational Imaging Division, University of California, Los Angeles, Los Angeles, CA, 90095, USA.<br /><searchLink fieldCode="AU" term="%22Abt+ER%22">Abt ER</searchLink>; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; 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Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, 90095, USA.<br /><searchLink fieldCode="AU" term="%22Whitelegge+J%22">Whitelegge J</searchLink>; The Pasarow Mass Spectrometry Laboratory, Neuropsychiatric Institute-Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, 90095, USA.<br /><searchLink fieldCode="AU" term="%22Faull+KF%22">Faull KF</searchLink>; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Ahmanson Translational Imaging Division, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; The Pasarow Mass Spectrometry Laboratory, Neuropsychiatric Institute-Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, 90095, USA.<br /><searchLink fieldCode="AU" term="%22Donahue+TR%22">Donahue TR</searchLink>; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Ahmanson Translational Imaging Division, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Department of Surgery, University of California, Los Angeles, Los Angeles, CA, 90095, USA.<br /><searchLink fieldCode="AU" term="%22Czernin+J%22">Czernin J</searchLink>; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.; Ahmanson Translational Imaging Division, University of California, Los Angeles, Los Angeles, CA, 90095, USA.<br /><searchLink fieldCode="AU" term="%22Radu+CG%22">Radu CG</searchLink>; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, 90095, USA. cradu@mednet.ucla.edu.; Ahmanson Translational Imaging Division, University of California, Los Angeles, Los Angeles, CA, 90095, USA. cradu@mednet.ucla.edu.
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