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Direct detection of early-stage cancers using circulating tumor DNA.

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Title: Direct detection of early-stage cancers using circulating tumor DNA.
Authors: Phallen J; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Sausen M; Personal Genome Diagnostics, Baltimore, MD 21224, USA., Adleff V; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Leal A; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Hruban C; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., White J; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Anagnostou V; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Fiksel J; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Cristiano S; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Papp E; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Speir S; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Reinert T; Department of Molecular Medicine, Aarhus University Hospital, DK-8200 Aarhus, Denmark., Orntoft MW; Department of Molecular Medicine, Aarhus University Hospital, DK-8200 Aarhus, Denmark., Woodward BD; Division of Hematology and Oncology, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA., Murphy D; Personal Genome Diagnostics, Baltimore, MD 21224, USA., Parpart-Li S; Personal Genome Diagnostics, Baltimore, MD 21224, USA., Riley D; Personal Genome Diagnostics, Baltimore, MD 21224, USA., Nesselbush M; Personal Genome Diagnostics, Baltimore, MD 21224, USA., Sengamalay N; Personal Genome Diagnostics, Baltimore, MD 21224, USA., Georgiadis A; Personal Genome Diagnostics, Baltimore, MD 21224, USA., Li QK; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Madsen MR; Department of Surgery, Herning Regional Hospital, DK-7400 Herning, Denmark., Mortensen FV; Department of Surgical Gastroenterology, Aarhus University Hospital, DK-8000 Aarhus, Denmark., Huiskens J; Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.; Department of Medical Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands., Punt C; Department of Medical Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands., van Grieken N; Department of Pathology, VU University Medical Center, Amsterdam 1081 HV, Netherlands., Fijneman R; Department of Pathology, Netherlands Cancer Institute, Amsterdam 1066 CX, Netherlands., Meijer G; Department of Pathology, Netherlands Cancer Institute, Amsterdam 1066 CX, Netherlands., Husain H; Division of Hematology and Oncology, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA., Scharpf RB; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Diaz LA Jr; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Jones S; Personal Genome Diagnostics, Baltimore, MD 21224, USA., Angiuoli S; Personal Genome Diagnostics, Baltimore, MD 21224, USA., Ørntoft T; Department of Molecular Medicine, Aarhus University Hospital, DK-8200 Aarhus, Denmark., Nielsen HJ; Department of Surgical Gastroenterology 360, Hvidovre Hospital, Hvidovre, Denmark., Andersen CL; Department of Molecular Medicine, Aarhus University Hospital, DK-8200 Aarhus, Denmark., Velculescu VE; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. velculescu@jhmi.edu.
Source: Science translational medicine [Sci Transl Med] 2017 Aug 16; Vol. 9 (403).
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Phallen+J%22">Phallen J</searchLink>; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.<br /><searchLink fieldCode="AU" term="%22Sausen+M%22">Sausen M</searchLink>; Personal Genome Diagnostics, Baltimore, MD 21224, USA.<br /><searchLink fieldCode="AU" term="%22Adleff+V%22">Adleff V</searchLink>; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.<br /><searchLink fieldCode="AU" term="%22Leal+A%22">Leal A</searchLink>; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.<br /><searchLink fieldCode="AU" term="%22Hruban+C%22">Hruban C</searchLink>; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.<br /><searchLink fieldCode="AU" term="%22White+J%22">White J</searchLink>; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.<br /><searchLink fieldCode="AU" term="%22Anagnostou+V%22">Anagnostou V</searchLink>; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.<br /><searchLink fieldCode="AU" term="%22Fiksel+J%22">Fiksel J</searchLink>; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.<br /><searchLink fieldCode="AU" term="%22Cristiano+S%22">Cristiano S</searchLink>; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.<br /><searchLink fieldCode="AU" term="%22Papp+E%22">Papp E</searchLink>; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.<br /><searchLink fieldCode="AU" term="%22Speir+S%22">Speir S</searchLink>; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.<br /><searchLink fieldCode="AU" term="%22Reinert+T%22">Reinert T</searchLink>; Department of Molecular Medicine, Aarhus University Hospital, DK-8200 Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Orntoft+MW%22">Orntoft MW</searchLink>; 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Personal Genome Diagnostics, Baltimore, MD 21224, USA.<br /><searchLink fieldCode="AU" term="%22Li+QK%22">Li QK</searchLink>; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.<br /><searchLink fieldCode="AU" term="%22Madsen+MR%22">Madsen MR</searchLink>; Department of Surgery, Herning Regional Hospital, DK-7400 Herning, Denmark.<br /><searchLink fieldCode="AU" term="%22Mortensen+FV%22">Mortensen FV</searchLink>; Department of Surgical Gastroenterology, Aarhus University Hospital, DK-8000 Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Huiskens+J%22">Huiskens J</searchLink>; Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.; Department of Medical Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Punt+C%22">Punt C</searchLink>; Department of Medical Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Grieken+N%22">van Grieken N</searchLink>; 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Personal Genome Diagnostics, Baltimore, MD 21224, USA.<br /><searchLink fieldCode="AU" term="%22Angiuoli+S%22">Angiuoli S</searchLink>; Personal Genome Diagnostics, Baltimore, MD 21224, USA.<br /><searchLink fieldCode="AU" term="%22Ørntoft+T%22">Ørntoft T</searchLink>; Department of Molecular Medicine, Aarhus University Hospital, DK-8200 Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Nielsen+HJ%22">Nielsen HJ</searchLink>; Department of Surgical Gastroenterology 360, Hvidovre Hospital, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Andersen+CL%22">Andersen CL</searchLink>; Department of Molecular Medicine, Aarhus University Hospital, DK-8200 Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Velculescu+VE%22">Velculescu VE</searchLink>; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. velculescu@jhmi.edu.
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