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Preclinical Evaluation of 18F-RO6958948, 11C-RO6931643, and 11C-RO6924963 as Novel PET Radiotracers for Imaging Tau Aggregates in Alzheimer Disease.

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Title: Preclinical Evaluation of 18F-RO6958948, 11C-RO6931643, and 11C-RO6924963 as Novel PET Radiotracers for Imaging Tau Aggregates in Alzheimer Disease.
Authors: Honer M; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland michael.honer@roche.com., Gobbi L; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Knust H; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Kuwabara H; PET Center, Division of Nuclear Medicine, Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Section of High Resolution Brain PET, PET Center, Division of Nuclear Medicine, Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Muri D; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Koerner M; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Valentine H; PET Center, Division of Nuclear Medicine, Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Section of High Resolution Brain PET, PET Center, Division of Nuclear Medicine, Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Dannals RF; PET Center, Division of Nuclear Medicine, Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Wong DF; PET Center, Division of Nuclear Medicine, Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Section of High Resolution Brain PET, PET Center, Division of Nuclear Medicine, Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland; and.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Borroni E; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
Source: Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2018 Apr; Vol. 59 (4), pp. 675-681. Date of Electronic Publication: 2017 Sep 28.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Society of Nuclear Medicine Country of Publication: United States NLM ID: 0217410 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-5667 (Electronic) Linking ISSN: 01615505 NLM ISO Abbreviation: J Nucl Med Subsets: MEDLINE
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  Data: Preclinical Evaluation of <superscript>18</superscript>F-RO6958948, <superscript>11</superscript>C-RO6931643, and <superscript>11</superscript>C-RO6924963 as Novel PET Radiotracers for Imaging Tau Aggregates in Alzheimer Disease.
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  Data: <searchLink fieldCode="AU" term="%22Honer+M%22">Honer M</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland michael.honer@roche.com.<br /><searchLink fieldCode="AU" term="%22Gobbi+L%22">Gobbi L</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Knust+H%22">Knust H</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kuwabara+H%22">Kuwabara H</searchLink>; PET Center, Division of Nuclear Medicine, Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Section of High Resolution Brain PET, PET Center, Division of Nuclear Medicine, Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Muri+D%22">Muri D</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Koerner+M%22">Koerner M</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Valentine+H%22">Valentine H</searchLink>; PET Center, Division of Nuclear Medicine, Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Section of High Resolution Brain PET, PET Center, Division of Nuclear Medicine, Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Dannals+RF%22">Dannals RF</searchLink>; PET Center, Division of Nuclear Medicine, Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Wong+DF%22">Wong DF</searchLink>; PET Center, Division of Nuclear Medicine, Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Section of High Resolution Brain PET, PET Center, Division of Nuclear Medicine, Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland; and.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Borroni+E%22">Borroni E</searchLink>; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
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