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Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism.

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Title: Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism.
Authors: Bilanges B; UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK. b.bilanges@ucl.ac.uk., Alliouachene S; UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK., Pearce W; UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK., Morelli D; UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK., Szabadkai G; Department of Cell and Developmental Biology, Consortium for Mitochondrial Research, University College London, Gower Street, London, WC1E 6BT, UK.; Department of Biomedical Sciences, University of Padua, Padua, 58/B via Ugo, Bassi, 35121, Italy., Chung YL; Cancer Research UK Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research London, 123 Old Brompton Road, London, SW7 3RP, UK., Chicanne G; Inserm/UPS UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires, 1 Avenue Jean Poulhès BP 84225, 31432, Toulouse Cedex 4, France., Valet C; Inserm/UPS UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires, 1 Avenue Jean Poulhès BP 84225, 31432, Toulouse Cedex 4, France., Hill JM; Department of Cell and Developmental Biology, Consortium for Mitochondrial Research, University College London, Gower Street, London, WC1E 6BT, UK., Voshol PJ; Metabolic Research Laboratories, MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Level 4, Box 289, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK., Collinson L; The Francis Crick Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London, WC2A 3LY, UK., Peddie C; The Francis Crick Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London, WC2A 3LY, UK., Ali K; UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK., Ghazaly E; Centre of Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK., Rajeeve V; Centre of Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK., Trichas G; Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK., Srinivas S; Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK., Chaussade C; UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK., Salamon RS; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, 10461, NY, USA., Backer JM; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, 10461, NY, USA., Scudamore CL; Mary Lyon Centre, MRC Harwell, Harwell Science and Innovation Campus, Harwell, OX11 0RD, UK., Whitehead MA; UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK., Keaney EP; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Murphy LO; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Semple RK; Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK., Payrastre B; Inserm/UPS UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires, 1 Avenue Jean Poulhès BP 84225, 31432, Toulouse Cedex 4, France., Tooze SA; The Francis Crick Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London, WC2A 3LY, UK., Vanhaesebroeck B; UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK. bart.vanh@ucl.ac.uk.
Source: Nature communications [Nat Commun] 2017 Nov 27; Vol. 8 (1), pp. 1804. Date of Electronic Publication: 2017 Nov 27.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism.
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  Data: <searchLink fieldCode="AU" term="%22Bilanges+B%22">Bilanges B</searchLink>; UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK. b.bilanges@ucl.ac.uk.<br /><searchLink fieldCode="AU" term="%22Alliouachene+S%22">Alliouachene S</searchLink>; UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Pearce+W%22">Pearce W</searchLink>; UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Morelli+D%22">Morelli D</searchLink>; UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Szabadkai+G%22">Szabadkai G</searchLink>; Department of Cell and Developmental Biology, Consortium for Mitochondrial Research, University College London, Gower Street, London, WC1E 6BT, UK.; Department of Biomedical Sciences, University of Padua, Padua, 58/B via Ugo, Bassi, 35121, Italy.<br /><searchLink fieldCode="AU" term="%22Chung+YL%22">Chung YL</searchLink>; Cancer Research UK Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research London, 123 Old Brompton Road, London, SW7 3RP, UK.<br /><searchLink fieldCode="AU" term="%22Chicanne+G%22">Chicanne G</searchLink>; Inserm/UPS UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires, 1 Avenue Jean Poulhès BP 84225, 31432, Toulouse Cedex 4, France.<br /><searchLink fieldCode="AU" term="%22Valet+C%22">Valet C</searchLink>; Inserm/UPS UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires, 1 Avenue Jean Poulhès BP 84225, 31432, Toulouse Cedex 4, France.<br /><searchLink fieldCode="AU" term="%22Hill+JM%22">Hill JM</searchLink>; Department of Cell and Developmental Biology, Consortium for Mitochondrial Research, University College London, Gower Street, London, WC1E 6BT, UK.<br /><searchLink fieldCode="AU" term="%22Voshol+PJ%22">Voshol PJ</searchLink>; Metabolic Research Laboratories, MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Level 4, Box 289, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Collinson+L%22">Collinson L</searchLink>; The Francis Crick Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London, WC2A 3LY, UK.<br /><searchLink fieldCode="AU" term="%22Peddie+C%22">Peddie C</searchLink>; The Francis Crick Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London, WC2A 3LY, UK.<br /><searchLink fieldCode="AU" term="%22Ali+K%22">Ali K</searchLink>; UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Ghazaly+E%22">Ghazaly E</searchLink>; Centre of Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK.<br /><searchLink fieldCode="AU" term="%22Rajeeve+V%22">Rajeeve V</searchLink>; Centre of Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK.<br /><searchLink fieldCode="AU" term="%22Trichas+G%22">Trichas G</searchLink>; Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.<br /><searchLink fieldCode="AU" term="%22Srinivas+S%22">Srinivas S</searchLink>; Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.<br /><searchLink fieldCode="AU" term="%22Chaussade+C%22">Chaussade C</searchLink>; UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Salamon+RS%22">Salamon RS</searchLink>; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, 10461, NY, USA.<br /><searchLink fieldCode="AU" term="%22Backer+JM%22">Backer JM</searchLink>; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, 10461, NY, USA.<br /><searchLink fieldCode="AU" term="%22Scudamore+CL%22">Scudamore CL</searchLink>; Mary Lyon Centre, MRC Harwell, Harwell Science and Innovation Campus, Harwell, OX11 0RD, UK.<br /><searchLink fieldCode="AU" term="%22Whitehead+MA%22">Whitehead MA</searchLink>; UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Keaney+EP%22">Keaney EP</searchLink>; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Murphy+LO%22">Murphy LO</searchLink>; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Semple+RK%22">Semple RK</searchLink>; Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Payrastre+B%22">Payrastre B</searchLink>; Inserm/UPS UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires, 1 Avenue Jean Poulhès BP 84225, 31432, Toulouse Cedex 4, France.<br /><searchLink fieldCode="AU" term="%22Tooze+SA%22">Tooze SA</searchLink>; The Francis Crick Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London, WC2A 3LY, UK.<br /><searchLink fieldCode="AU" term="%22Vanhaesebroeck+B%22">Vanhaesebroeck B</searchLink>; UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK. bart.vanh@ucl.ac.uk.
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