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Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity.

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Title: Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity.
Authors: Preite S; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA. silvia.preite@nih.gov.; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. silvia.preite@nih.gov., Cannons JL; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Radtke AJ; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Vujkovic-Cvijin I; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Gomez-Rodriguez J; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Volpi S; Clinica Pediatrica e Reumatologia, Centro per le Malattie Autoinfiammatorie e Immunodeficienze, Istituto Giannina Gaslini, Genoa, Italy.; Università degli Studi di Genova, Genoa, Italy., Huang B; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Cheng J; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Collins N; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Reilley J; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Handon R; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Dobbs K; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Huq L; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Raman I; Microarray Core Facility, University of Texas Southwestern Medical Center, Dallas, TX, USA., Zhu C; Microarray Core Facility, University of Texas Southwestern Medical Center, Dallas, TX, USA., Li QZ; Microarray Core Facility, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Li MO; Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA., Pittaluga S; Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Uzel G; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Notarangelo LD; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Belkaid Y; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Microbiome Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Germain RN; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Schwartzberg PL; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA. pams@mail.nih.gov.; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. pams@mail.nih.gov.
Source: Nature immunology [Nat Immunol] 2018 Sep; Vol. 19 (9), pp. 986-1000. Date of Electronic Publication: 2018 Aug 20.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
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  Data: Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity.
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  Data: <searchLink fieldCode="AU" term="%22Preite+S%22">Preite S</searchLink>; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA. silvia.preite@nih.gov.; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. silvia.preite@nih.gov.<br /><searchLink fieldCode="AU" term="%22Cannons+JL%22">Cannons JL</searchLink>; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Radtke+AJ%22">Radtke AJ</searchLink>; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Vujkovic-Cvijin+I%22">Vujkovic-Cvijin I</searchLink>; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Gomez-Rodriguez+J%22">Gomez-Rodriguez J</searchLink>; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Volpi+S%22">Volpi S</searchLink>; Clinica Pediatrica e Reumatologia, Centro per le Malattie Autoinfiammatorie e Immunodeficienze, Istituto Giannina Gaslini, Genoa, Italy.; Università degli Studi di Genova, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Huang+B%22">Huang B</searchLink>; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Cheng+J%22">Cheng J</searchLink>; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Collins+N%22">Collins N</searchLink>; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Reilley+J%22">Reilley J</searchLink>; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Handon+R%22">Handon R</searchLink>; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Dobbs+K%22">Dobbs K</searchLink>; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Huq+L%22">Huq L</searchLink>; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Raman+I%22">Raman I</searchLink>; Microarray Core Facility, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+C%22">Zhu C</searchLink>; Microarray Core Facility, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Li+QZ%22">Li QZ</searchLink>; Microarray Core Facility, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Li+MO%22">Li MO</searchLink>; Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Pittaluga+S%22">Pittaluga S</searchLink>; Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Uzel+G%22">Uzel G</searchLink>; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Notarangelo+LD%22">Notarangelo LD</searchLink>; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Belkaid+Y%22">Belkaid Y</searchLink>; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Microbiome Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Germain+RN%22">Germain RN</searchLink>; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Schwartzberg+PL%22">Schwartzberg PL</searchLink>; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA. pams@mail.nih.gov.; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. pams@mail.nih.gov.
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  Data: <searchLink fieldCode="JN" term="%22100941354%22">Nature immunology</searchLink> [Nat Immunol] 2018 Sep; Vol. 19 (9), pp. 986-1000. <i>Date of Electronic Publication: </i>2018 Aug 20.
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