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Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals.

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Title: Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals.
Authors: Danese E; Clinical Biochemistry Section, Department of Neurological, Biomedical and Movement Sciences, University of Verona, Verona, Italy., Raimondi S; General Medicine and Hypertension Unit, Department of Medicine, University of Verona, Verona, Italy., Montagnana M; Clinical Biochemistry Section, Department of Neurological, Biomedical and Movement Sciences, University of Verona, Verona, Italy., Tagetti A; General Medicine and Hypertension Unit, Department of Medicine, University of Verona, Verona, Italy., Langaee T; Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, Florida, USA., Borgiani P; Genetics Section, Department of Biomedicine and Prevention, University of Rome 'Tor Vergata,', Rome, Italy., Ciccacci C; Genetics Section, Department of Biomedicine and Prevention, University of Rome 'Tor Vergata,', Rome, Italy., Carcas AJ; Clinical Pharmacology Department, La Paz University Hospital, School of Medicine, IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain.; Spanish Clinical Research Network-SCReN, Madrid, Spain., Borobia AM; Clinical Pharmacology Department, La Paz University Hospital, School of Medicine, IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain.; Spanish Clinical Research Network-SCReN, Madrid, Spain., Tong HY; Clinical Pharmacology Department, La Paz University Hospital, School of Medicine, IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain.; Spanish Clinical Research Network-SCReN, Madrid, Spain., Dávila-Fajardo C; Department of Clinical Pharmacy, San Cecilio University Hospital, Institute for Biomedical Research, IBS, Granada, Spain., Rodrigues Botton M; Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Bourgeois S; William Harvey Research Institute, Barts & the London Medical School, Queen Mary University of London, London, UK., Deloukas P; William Harvey Research Institute, Barts & the London Medical School, Queen Mary University of London, London, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia., Caldwell MD; Center for Hyperbaric Medicine and Tissue Repair, Marshfield Clinic, Marshfield, Wisconsin, USA., Burmester JK; Grants Office, Gundersen Health System, La Crosse, Wisconsin, USA., Berg RL; Clinical Research Center, Marshfield Clinic Research Foundation, Marshfield, Wisconsin, USA., Cavallari LH; Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, Florida, USA., Drozda K; Department of Pharmacy Practice, University of Illinois at Chicago, Chicago, Illinois, USA., Huang M; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China., Zhao LZ; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China., Cen HJ; Guangzhou Women and Children's Medical Center, Guangzhou, China., Gonzalez-Conejero R; Centro Regional de Hemodonación, Hospital Universitario Morales Meseguer, Universidad de Murcia, Murcia, Spain., Roldan V; Centro Regional de Hemodonación, Hospital Universitario Morales Meseguer, Universidad de Murcia, Murcia, Spain., Nakamura Y; Research Group for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Mushiroda T; Research Group for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Gong IY; Division of Clinical Pharmacology, Department of Medicine, University of Western Ontario, London, Ontario, Canada., Kim RB; Division of Clinical Pharmacology, Department of Medicine, University of Western Ontario, London, Ontario, Canada., Hirai K; Department of Clinical Pharmacology & Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan., Itoh K; Department of Clinical Pharmacology & Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan., Isaza C; Faculty of Heath Sciences, Laboratory of Medical Genetics, Universidad Tecnológica de Pereira, Pereira, Colombia., Beltrán L; Faculty of Heath Sciences, Laboratory of Medical Genetics, Universidad Tecnológica de Pereira, Pereira, Colombia.; Faculty of Heath Sciences, Unidad Central del Valle del Cauca, Valle del Cauca, Colombia., Jiménez-Varo E; Clinical Laboratory Department, Hospital La Línea, Cádiz, Spain., Cañadas-Garre M; Centre for Public Health, School of Medicine, Dentistry, and Biomedical Sciences, Queen's University Belfast, Belfast, UK., Giontella A; General Medicine and Hypertension Unit, Department of Medicine, University of Verona, Verona, Italy., Kringen MK; Department of Pharmacology, Oslo University Hospital, Ullevål, Oslo, Norway.; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway., Haug KBF; Department of Medical Biochemistry, Oslo University Hospital, Ullevål, Oslo, Norway., Gwak HS; Division of Life and Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, Korea., Lee KE; College of Pharmacy, Chungbuk National University, Cheongju-si, Korea., Minuz P; General Medicine and Hypertension Unit, Department of Medicine, University of Verona, Verona, Italy., Lee MTM; Genomic Medicine Institute, Geisinger Health System, Danville, Pennsylvania, USA.; National Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Lubitz SA; Cardiac Arrhythmia Service & Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA., Scott S; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Mazzaccara C; CEINGE-Biotecnologie Avanzate s.c.ar.l., Napoli, Italy.; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, Napoli, Italy., Sacchetti L; CEINGE-Biotecnologie Avanzate s.c.ar.l., Napoli, Italy.; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, Napoli, Italy., Genç E; Department of Pharmacology, Yeditepe University, Istanbul, Turkey., Özer M; Department of Pharmacology, Yeditepe University, Istanbul, Turkey., Pathare A; College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman., Krishnamoorthy R; INSERM, UMR_S 763, Paris, France., Paldi A; Ecole Pratique des Hautes Etudes, UMRS_951, Genethon, Evry, France., Siguret V; Sorbonne Paris Cité, INSERM, UMR-S-1140, Université Paris Descartes, Paris, France.; Assistance Publique Hôpitaux de Paris, Hôpital Lariboisière, Service d'Hématologie Biologique, Paris, France., Loriot MA; Sorbonne Paris Cité, INSERM, UMR-S-1147, Université Paris Descartes, Paris, France.; Assistance Publique Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Biochimie UF Pharmacogénétique et Oncologie Moléculaire, Paris, France., Kutala VK; Department of Clinical Pharmacology & Therapeutics, Nizam's Institute of Medical Sciences, Hyderabad, India., Suarez-Kurtz G; Coordenação de Pesquisa, Instituto Nacional de Câncer, Rio de Janeiro, Brazil., Perini J; Research Laboratory of Pharmaceutical Sciences, West Zone State University-UEZO, Rio de Janeiro, Brazil., Denny JC; Department of Medicine and Department of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee, USA., Ramirez AH; Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA., Mittal B; Department of Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, India., Rathore SS; Department of Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, India., Sagreiya H; Department of Genetics, Stanford University School of Medicine, Stanford, California, USA., Altman R; Department of Genetics, Stanford University School of Medicine, Stanford, California, USA., Shahin MHA; Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, Florida, USA., Khalifa SI; College of Pharmacy, Gulf Medical University, Ajman, United Arab Emirates., Limdi NA; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Rivers C; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Shendre A; Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University Purdue University, Indianapolis, Indiana, USA., Dillon C; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Suriapranata IM; Mochtar Riady Institute for Nanotechnology, Universitas Pelita Harapan, Lippo Karawaci, Tangerang, Banten, Indonesia., Zhou HH; Institute of Clinical Pharmacology, Central South University, Hunan Sheng, China., Tan SL; Department of Pharmacy, Xiangya Second Hospital, Central South University, Hunan Sheng, China., Tatarunas V; Laboratory of Molecular Cardiology, Institute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania., Lesauskaite V; Laboratory of Molecular Cardiology, Institute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania., Zhang Y; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands., Maitland-van der Zee AH; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.; Department of Respiratory Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Verhoef TI; Department of Applied Health Research, University College London, London, UK., de Boer A; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands., Taljaard M; Clinica Epidemiology Program and Department of Epidemiology and Community Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada., Zambon CF; Department of Medicine-DIMED, University of Padua, Padua, Italy., Pengo V; Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy., Zhang JE; Wolfson Centre for Personalised Medicine, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK., Pirmohamed M; Wolfson Centre for Personalised Medicine, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK., Johnson JA; Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, Florida, USA., Fava C; General Medicine and Hypertension Unit, Department of Medicine, University of Verona, Verona, Italy.
Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2019 Jun; Vol. 105 (6), pp. 1477-1491. Date of Electronic Publication: 2019 Feb 17.
Publication Type: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals.
– Name: Author
  Label: Authors
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  Data: <searchLink fieldCode="AU" term="%22Danese+E%22">Danese E</searchLink>; Clinical Biochemistry Section, Department of Neurological, Biomedical and Movement Sciences, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Raimondi+S%22">Raimondi S</searchLink>; General Medicine and Hypertension Unit, Department of Medicine, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Montagnana+M%22">Montagnana M</searchLink>; Clinical Biochemistry Section, Department of Neurological, Biomedical and Movement Sciences, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Tagetti+A%22">Tagetti A</searchLink>; General Medicine and Hypertension Unit, Department of Medicine, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Langaee+T%22">Langaee T</searchLink>; Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Borgiani+P%22">Borgiani P</searchLink>; Genetics Section, Department of Biomedicine and Prevention, University of Rome 'Tor Vergata,', Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Ciccacci+C%22">Ciccacci C</searchLink>; Genetics Section, Department of Biomedicine and Prevention, University of Rome 'Tor Vergata,', Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Carcas+AJ%22">Carcas AJ</searchLink>; Clinical Pharmacology Department, La Paz University Hospital, School of Medicine, IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain.; Spanish Clinical Research Network-SCReN, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Borobia+AM%22">Borobia AM</searchLink>; Clinical Pharmacology Department, La Paz University Hospital, School of Medicine, IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain.; Spanish Clinical Research Network-SCReN, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Tong+HY%22">Tong HY</searchLink>; Clinical Pharmacology Department, La Paz University Hospital, School of Medicine, IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain.; Spanish Clinical Research Network-SCReN, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Dávila-Fajardo+C%22">Dávila-Fajardo C</searchLink>; Department of Clinical Pharmacy, San Cecilio University Hospital, Institute for Biomedical Research, IBS, Granada, Spain.<br /><searchLink fieldCode="AU" term="%22Rodrigues+Botton+M%22">Rodrigues Botton M</searchLink>; Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Bourgeois+S%22">Bourgeois S</searchLink>; William Harvey Research Institute, Barts & the London Medical School, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Deloukas+P%22">Deloukas P</searchLink>; William Harvey Research Institute, Barts & the London Medical School, Queen Mary University of London, London, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Caldwell+MD%22">Caldwell MD</searchLink>; Center for Hyperbaric Medicine and Tissue Repair, Marshfield Clinic, Marshfield, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Burmester+JK%22">Burmester JK</searchLink>; Grants Office, Gundersen Health System, La Crosse, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Berg+RL%22">Berg RL</searchLink>; Clinical Research Center, Marshfield Clinic Research Foundation, Marshfield, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Cavallari+LH%22">Cavallari LH</searchLink>; Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Drozda+K%22">Drozda K</searchLink>; Department of Pharmacy Practice, University of Illinois at Chicago, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Huang+M%22">Huang M</searchLink>; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhao+LZ%22">Zhao LZ</searchLink>; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Cen+HJ%22">Cen HJ</searchLink>; Guangzhou Women and Children's Medical Center, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Gonzalez-Conejero+R%22">Gonzalez-Conejero R</searchLink>; Centro Regional de Hemodonación, Hospital Universitario Morales Meseguer, Universidad de Murcia, Murcia, Spain.<br /><searchLink fieldCode="AU" term="%22Roldan+V%22">Roldan V</searchLink>; Centro Regional de Hemodonación, Hospital Universitario Morales Meseguer, Universidad de Murcia, Murcia, Spain.<br /><searchLink fieldCode="AU" term="%22Nakamura+Y%22">Nakamura Y</searchLink>; Research Group for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Mushiroda+T%22">Mushiroda T</searchLink>; Research Group for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Gong+IY%22">Gong IY</searchLink>; Division of Clinical Pharmacology, Department of Medicine, University of Western Ontario, London, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Kim+RB%22">Kim RB</searchLink>; Division of Clinical Pharmacology, Department of Medicine, University of Western Ontario, London, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Hirai+K%22">Hirai K</searchLink>; Department of Clinical Pharmacology & Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Itoh+K%22">Itoh K</searchLink>; Department of Clinical Pharmacology & Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Isaza+C%22">Isaza C</searchLink>; Faculty of Heath Sciences, Laboratory of Medical Genetics, Universidad Tecnológica de Pereira, Pereira, Colombia.<br /><searchLink fieldCode="AU" term="%22Beltrán+L%22">Beltrán L</searchLink>; Faculty of Heath Sciences, Laboratory of Medical Genetics, Universidad Tecnológica de Pereira, Pereira, Colombia.; Faculty of Heath Sciences, Unidad Central del Valle del Cauca, Valle del Cauca, Colombia.<br /><searchLink fieldCode="AU" term="%22Jiménez-Varo+E%22">Jiménez-Varo E</searchLink>; Clinical Laboratory Department, Hospital La Línea, Cádiz, Spain.<br /><searchLink fieldCode="AU" term="%22Cañadas-Garre+M%22">Cañadas-Garre M</searchLink>; Centre for Public Health, School of Medicine, Dentistry, and Biomedical Sciences, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Giontella+A%22">Giontella A</searchLink>; General Medicine and Hypertension Unit, Department of Medicine, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Kringen+MK%22">Kringen MK</searchLink>; Department of Pharmacology, Oslo University Hospital, Ullevål, Oslo, Norway.; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Haug+KBF%22">Haug KBF</searchLink>; Department of Medical Biochemistry, Oslo University Hospital, Ullevål, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Gwak+HS%22">Gwak HS</searchLink>; Division of Life and Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Lee+KE%22">Lee KE</searchLink>; College of Pharmacy, Chungbuk National University, Cheongju-si, Korea.<br /><searchLink fieldCode="AU" term="%22Minuz+P%22">Minuz P</searchLink>; General Medicine and Hypertension Unit, Department of Medicine, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Lee+MTM%22">Lee MTM</searchLink>; Genomic Medicine Institute, Geisinger Health System, Danville, Pennsylvania, USA.; National Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lubitz+SA%22">Lubitz SA</searchLink>; Cardiac Arrhythmia Service & Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Scott+S%22">Scott S</searchLink>; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Mazzaccara+C%22">Mazzaccara C</searchLink>; CEINGE-Biotecnologie Avanzate s.c.ar.l., Napoli, Italy.; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Sacchetti+L%22">Sacchetti L</searchLink>; CEINGE-Biotecnologie Avanzate s.c.ar.l., Napoli, Italy.; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Genç+E%22">Genç E</searchLink>; Department of Pharmacology, Yeditepe University, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Özer+M%22">Özer M</searchLink>; Department of Pharmacology, Yeditepe University, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Pathare+A%22">Pathare A</searchLink>; College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman.<br /><searchLink fieldCode="AU" term="%22Krishnamoorthy+R%22">Krishnamoorthy R</searchLink>; INSERM, UMR_S 763, Paris, France.<br /><searchLink fieldCode="AU" term="%22Paldi+A%22">Paldi A</searchLink>; Ecole Pratique des Hautes Etudes, UMRS_951, Genethon, Evry, France.<br /><searchLink fieldCode="AU" term="%22Siguret+V%22">Siguret V</searchLink>; Sorbonne Paris Cité, INSERM, UMR-S-1140, Université Paris Descartes, Paris, France.; Assistance Publique Hôpitaux de Paris, Hôpital Lariboisière, Service d'Hématologie Biologique, Paris, France.<br /><searchLink fieldCode="AU" term="%22Loriot+MA%22">Loriot MA</searchLink>; Sorbonne Paris Cité, INSERM, UMR-S-1147, Université Paris Descartes, Paris, France.; Assistance Publique Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Biochimie UF Pharmacogénétique et Oncologie Moléculaire, Paris, France.<br /><searchLink fieldCode="AU" term="%22Kutala+VK%22">Kutala VK</searchLink>; Department of Clinical Pharmacology & Therapeutics, Nizam's Institute of Medical Sciences, Hyderabad, India.<br /><searchLink fieldCode="AU" term="%22Suarez-Kurtz+G%22">Suarez-Kurtz G</searchLink>; Coordenação de Pesquisa, Instituto Nacional de Câncer, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Perini+J%22">Perini J</searchLink>; Research Laboratory of Pharmaceutical Sciences, West Zone State University-UEZO, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Denny+JC%22">Denny JC</searchLink>; Department of Medicine and Department of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Ramirez+AH%22">Ramirez AH</searchLink>; Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Mittal+B%22">Mittal B</searchLink>; Department of Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, India.<br /><searchLink fieldCode="AU" term="%22Rathore+SS%22">Rathore SS</searchLink>; Department of Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, India.<br /><searchLink fieldCode="AU" term="%22Sagreiya+H%22">Sagreiya H</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Altman+R%22">Altman R</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Shahin+MHA%22">Shahin MHA</searchLink>; Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Khalifa+SI%22">Khalifa SI</searchLink>; College of Pharmacy, Gulf Medical University, Ajman, United Arab Emirates.<br /><searchLink fieldCode="AU" term="%22Limdi+NA%22">Limdi NA</searchLink>; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.<br /><searchLink fieldCode="AU" term="%22Rivers+C%22">Rivers C</searchLink>; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.<br /><searchLink fieldCode="AU" term="%22Shendre+A%22">Shendre A</searchLink>; Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University Purdue University, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Dillon+C%22">Dillon C</searchLink>; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.<br /><searchLink fieldCode="AU" term="%22Suriapranata+IM%22">Suriapranata IM</searchLink>; Mochtar Riady Institute for Nanotechnology, Universitas Pelita Harapan, Lippo Karawaci, Tangerang, Banten, Indonesia.<br /><searchLink fieldCode="AU" term="%22Zhou+HH%22">Zhou HH</searchLink>; Institute of Clinical Pharmacology, Central South University, Hunan Sheng, China.<br /><searchLink fieldCode="AU" term="%22Tan+SL%22">Tan SL</searchLink>; Department of Pharmacy, Xiangya Second Hospital, Central South University, Hunan Sheng, China.<br /><searchLink fieldCode="AU" term="%22Tatarunas+V%22">Tatarunas V</searchLink>; Laboratory of Molecular Cardiology, Institute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania.<br /><searchLink fieldCode="AU" term="%22Lesauskaite+V%22">Lesauskaite V</searchLink>; Laboratory of Molecular Cardiology, Institute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Maitland-van+der+Zee+AH%22">Maitland-van der Zee AH</searchLink>; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.; Department of Respiratory Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Verhoef+TI%22">Verhoef TI</searchLink>; Department of Applied Health Research, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22de+Boer+A%22">de Boer A</searchLink>; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Taljaard+M%22">Taljaard M</searchLink>; Clinica Epidemiology Program and Department of Epidemiology and Community Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Zambon+CF%22">Zambon CF</searchLink>; Department of Medicine-DIMED, University of Padua, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Pengo+V%22">Pengo V</searchLink>; Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Zhang+JE%22">Zhang JE</searchLink>; Wolfson Centre for Personalised Medicine, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Pirmohamed+M%22">Pirmohamed M</searchLink>; Wolfson Centre for Personalised Medicine, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Johnson+JA%22">Johnson JA</searchLink>; Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Fava+C%22">Fava C</searchLink>; General Medicine and Hypertension Unit, Department of Medicine, University of Verona, Verona, Italy.
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  Data: <searchLink fieldCode="JN" term="%220372741%22">Clinical pharmacology and therapeutics</searchLink> [Clin Pharmacol Ther] 2019 Jun; Vol. 105 (6), pp. 1477-1491. <i>Date of Electronic Publication: </i>2019 Feb 17.
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  Data: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't
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  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley%22">Wiley </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0372741 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1532-6535 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200099236%22">00099236 </searchLink><i>NLM ISO Abbreviation: </i>Clin Pharmacol Ther <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1002/cpt.1323
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      – Code: eng
        Text: English
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        StartPage: 1477
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      – TitleFull: Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals.
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            – D: 01
              M: 06
              Text: 2019 Jun
              Type: published
              Y: 2019
          Identifiers:
            – Type: issn-electronic
              Value: 1532-6535
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            – TitleFull: Clinical pharmacology and therapeutics
              Type: main
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