GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.
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| Title: | GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. |
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| Authors: | Franceschini N; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, 27516, USA., Giambartolomei C; Department of Pathology and Laboratory Medicine, University of California (UCLA), Los Angeles, Los Angeles, CA, 90095, USA., de Vries PS; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Finan C; Institute of Cardiovascular Science, University College London, London, WC1 6BT, UK., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA., Huntley RP; Institute of Cardiovascular Science, University College London, London, WC1 6BT, UK., Lovering RC; Institute of Cardiovascular Science, University College London, London, WC1 6BT, UK., Tajuddin SM; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 20892, USA., Winkler TW; Department of Genetic Epidemiology, University of Regensburg, Regensburg, 93053, Germany., Graff M; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, 27516, USA., Kavousi M; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, The Netherlands., Dale C; Institute of Health Informatics, University College London, London, WC1E 6BT, UK., Smith AV; Icelandic Heart Association, Kopavogur, IS-201, Iceland.; University of Iceland, Reykjavik, 101, Iceland., Hofer E; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, 8036, Austria.; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, 8036, Austria., van Leeuwen EM; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, The Netherlands., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 3015, The Netherlands., Lu L; Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA., Scholz M; Institute for Medical Informatics, Statistics and Epidemiology, , University of Leipzig, Leipzig, 04107, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, 04107, Germany., Sargurupremraj M; Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, CHU Bordeaux, F-33000, Bordeaux, France., Pitkänen N; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, 20520, Finland., Franzén O; Department of Genetics and Genomic Sciences, The Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Clinical Gene Networks AB, Stockholm, 104 62, Sweden., Joshi PK; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK., Noordam R; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2300, RC, The Netherlands., Marioni RE; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK., Hwang SJ; Population Sciences Branch, Division of Intramural Research, NHLBI, NIH, Framingham, MA, 01702-5827, USA.; National Heart, Lung and Blood Institute's Intramural Research Program, Framingham Heart Study, Framingham, MA, 01702-5827, USA., Musani SK; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, 39216, USA., Schminke U; Department of Neurology, University Medicine Greifswald, Greifswald, 17475, Germany., Palmas W; Department of Medicine, Columbia University, New York, NY, 10032, USA., Isaacs A; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, The Netherlands.; Department of Biochemistry, Maastricht Centre for Systems Biology (MaCSBio), CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, 6229, The Netherlands., Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, 39216, USA., Zonderman AB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 20892, USA., Hofman A; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, The Netherlands.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, 17475, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, 17475, Germany., Cox AJ; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, 25157, USA.; Menzies Health Institute Queensland, Griffith University, Southport, QLD, 4222, Australia., Uitterlinden AG; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, 3015, The Netherlands., Wong A; MRC Unit for Lifelong Health and Ageing at UCL, London, WC1E 6BT, UK., Smit AJ; Department of Medicine, University of Groningen, University Medical Center Groningen, Groningen, 2300, The Netherlands., Newman AB; Department of Epidemiology, and School of Medicine, Division of Geriatric Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA., Britton A; Department of Epidemiology and Public Health, University College London, London, WC1E 6BT, UK., Ruusalepp A; Clinical Gene Networks AB, Stockholm, 104 62, Sweden.; Department of Pathophysiology, Institute of Biomedicine and Translation Medicine, University of Tartu, Biomeedikum, Tartu, 51010, Estonia.; Department of Cardiac Surgery, Tartu University Hospital, Tartu, 51010, Estonia., Sennblad B; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, 17177, Sweden.; Department of Cell and Molecular Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University, Uppsala, 75108, Sweden., Hedblad B; Department of Clinical Sciences in Malmö, Lund University, Malmö, SE-205 02, Sweden., Pasaniuc B; Department of Pathology and Laboratory Medicine, University of California (UCLA), Los Angeles, Los Angeles, CA, 90095, USA.; Department of Human Genetics, University of California (UCLA), Los Angeles, CA, 90095, USA., Penninx BW; Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, 1081, HL, The Netherlands., Langefeld CD; Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA., Wassel CL; Applied Sciences, Premier, Inc., Charlotte, NC, 28277, USA., Tzourio C; Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, CHU Bordeaux, F-33000, Bordeaux, France., Fava C; Department of Clinical Sciences in Malmö, Lund University, Malmö, SE-205 02, Sweden.; Department of Medicine, University of Verona, Verona, 37134, Italy., Baldassarre D; Department of Medical Biotechnology and Translational Medicine, Università di Milano, Milan, 20133, Italy.; Centro Cardiologico Monzino, IRCCS, Milan, 20138, Italy., O'Leary DH; St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA, 02135, USA., Teupser D; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, 04107, Germany.; Institute of Laboratory Medicine, University Hospital Munich, LMU Munich, 80539, Germany., Kuh D; MRC Unit for Lifelong Health and Ageing at UCL, London, WC1E 6BT, UK., Tremoli E; Centro Cardiologico Monzino, IRCCS, Milan, 20138, Italy.; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, 20133, Italy., Mannarino E; Department of Clinical and Experimental Medicine, Internal Medicine, Angiology and Arteriosclerosis Diseases, University of Perugia, Perugia, 06123, Italy., Grossi E; Centro Diagnostico Italiano, Milan, 20147, Italy., Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, 77030-3411, USA., Schadt EE; Department of Genetics and Genomic Sciences, The Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Clinical Gene Networks AB, Stockholm, 104 62, Sweden., Ingelsson E; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94309, USA.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, 75185, Sweden.; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, G1120, USA., Veglia F; Centro Cardiologico Monzino, IRCCS, Milan, 20138, Italy., Rivadeneira F; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, 3015, The Netherlands., Beutner F; Heart Center Leipzig, Leipzig, 04103, Germany., Chauhan G; Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, CHU Bordeaux, F-33000, Bordeaux, France.; Centre for Brain Research, Indian Institute of Science, Bangalore, 560012, India., Heiss G; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, 27516, USA., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 3015, The Netherlands., Campbell H; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK., Völzke H; Institute for Community Medicine, University Medicine Greifswald, Greifswald, 17475, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, 17475, Germany., Markus HS; Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK., Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, 2300, RC, The Netherlands., de Graaf J; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, 6525, GA, The Netherlands., Price J; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK., Pott J; Institute for Medical Informatics, Statistics and Epidemiology, , University of Leipzig, Leipzig, 04107, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, 04107, Germany., Hopewell JC; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK., Liang J; Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA., Thiery J; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, 04107, Germany.; Institute for Laboratory Medicine, University of Leipzig, Leipzig, 04109, Germany., Engmann J; Institute of Cardiovascular Science, University College London, London, WC1 6BT, UK., Gertow K; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, 17177, Sweden., Rice K; Department of Biostatistics, University of Washington, Seattle, WA, 98105, USA., Taylor KD; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Dhana K; Department of Internal Medicine, Rush University Medical Center, Chicago, IL, 60612, USA., Kiemeney LALM; Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, GA, 6525, The Netherlands., Lind L; Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, 751 05, Sweden., Raffield LM; Department of Genetics, University of North Carolina, Chapel Hill, NC, 27516, USA., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 20892, USA., Holdt LM; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, 04107, Germany.; Institute of Laboratory Medicine, University Hospital Munich, LMU Munich, 80539, Germany., Dörr M; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, 17475, Germany.; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, 17475, Germany., Dichgans M; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University (LMU), Munich, 80539, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, 81377, Germany., Traylor M; Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK., Sitzer M; Department of Neurology, Center for Neurology and Neurosurgery, Johann Wolfgang Goethe-University, Frankfurt am Main, 60323, Germany., Kumari M; Department of Epidemiology and Public Health, University College London, London, WC1E 6BT, UK.; Institute for Social and Economic Research, Essex University, Colchester, CO4 3SQ, UK., Kivimaki M; Department of Epidemiology and Public Health, University College London, London, WC1E 6BT, UK., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.; Data Tecnica International, Glen Echo, MD, 20812, USA., Melander O; Department of Clinical Sciences in Malmö, Lund University, Malmö, SE-205 02, Sweden., Raitakari O; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, 20520, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, 20521, Finland., Franco OH; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, The Netherlands.; Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, 3012, Switzerland., Rueda-Ochoa OL; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, The Netherlands.; Electrocardiography Research Group, School of Medicine, Universidad Industrial de Santander, Bucaramanga, Santander, 680003, Colombia., Roussos P; Department of Genetics and Genomic Sciences, The Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Psychiatry and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Mental Illness Research Education and Clinical Center (MIRECC), James J. Peters VA Medical Center, Bronx, New York, NY, 10468, USA., Whincup PH; Population Health Research Institute, St George's, University of London, London, SW17 0RE, UK., Amouyel P; Inserm U1167, F-59000, Lille, France.; Institut Pasteur de Lille, U1167, F-59000, Lille, France.; Université de Lille, U1167 - RID-AGE & Centre Hospitalier Universitaire de Lille, U1167, F-59000, Lille, France., Giral P; Sorbonne Université, Cardiovascular Prevention Unit, Pitié Salpétrière Hospital, Paris, 75013, France., Anugu P; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, 39216, USA., Wong Q; Collaborative Health Studies Coordinating Center, Department of Biostatistics, University of Washington, Seattle, WA, 98195, USA., Malik R; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University (LMU), Munich, 80539, Germany., Rauramaa R; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, 70210, Finland., Burkhardt R; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, 04107, Germany.; Institute of Laboratory Medicine, University of Leipzig, Leipzig, 04109, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, 93053, Germany., Hardy R; MRC Unit for Lifelong Health and Ageing at UCL, London, WC1E 6BT, UK., Schmidt R; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, 8036, Austria., de Mutsert R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333, The Netherlands., Morris RW; Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 1QU, UK., Strawbridge RJ; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, 17177, Sweden.; Mental Health and Wellbeing, Institute of Health and Wellbeing, University of Glasgow, Glasgow, G12 0XH, UK., Wannamethee SG; Department of Primary Care & Population Health, University College London, London, WC1E 6BT, UK., Hägg S; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE-171 77, Sweden., Shah S; Institute of Cardiovascular Science, University College London, London, WC1 6BT, UK., McLachlan S; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK., Trompet S; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2300, RC, The Netherlands.; Department of Cardiology, Leiden University Medical Center, Leiden, 2300, RC, The Netherlands., Seshadri S; Department of Neurology, Boston University School of Medicine, Boston, MA, 02118, USA., Kurl S; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, FI-70210, Finland., Heckbert SR; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, 98101, USA., Ring S; Population Health Science, Bristol Medical School, University of Bristol, Bristol, BS8 1QU, UK.; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, BS8 1TH, UK., Harris TB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 20892, USA., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33014, Finland.; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, 33014, Finland., Galesloot TE; Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, GA, 6525, The Netherlands., Shah T; Institute of Cardiovascular Science, University College London, London, WC1 6BT, UK., de Faire U; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, S-171 77, Sweden.; Department of Cardiology, Karolinska University Hospital, Stockholm, S-171 77, Sweden., Plagnol V; Genetics Institute, University College London, London, WC1E 6BT, UK., Rosamond WD; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, 27516, USA., Post W; Departments of Medicine and Epidemiology, Johns Hopkins University, Baltimore, MD, 21205, USA., Zhu X; Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA., Zhang X; National Heart, Lung and Blood Institute's Intramural Research Program, Framingham Heart Study, Framingham, MA, 01702-5827, USA.; Section of Biomedical Genetics, School of Medicine, Boston University, Boston, MA, 02215, USA., Guo X; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.; Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Saba Y; Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, 8010, Austria., Dehghan A; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, The Netherlands.; Department of Epidemiology & Biostatistics, Imperial College London, London, SW7 2AZ, UK., Seldenrijk A; GGZ inGeest and Amsterdam Public Health Research Institute, Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, 1081 HV, The Netherlands., Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Hamsten A; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, 17177, Sweden., Psaty BM; Kaiser Permanente Washington Health Research Institute, Seattle, WA, 98101, USA.; Cardiovascular Health Research Unit and Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, 98195, USA., van Duijn CM; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, The Netherlands.; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK., Lawlor DA; Population Health Science, Bristol Medical School, University of Bristol, Bristol, BS8 1QU, UK.; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, BS8 1TH, UK., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333, The Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands., Bowden DW; Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA., Schmidt H; Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, 8010, Austria., Wilson JF; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK.; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, 39216, USA., Rotter JI; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.; Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Wardlaw JM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Centre for Clinical Brain Sciences, and UK Dementia Research Institute at the University of Edinburgh, Edinburgh, EH16 4SB, UK., Deanfield J; Institute of Cardiovascular Science, University College London, London, WC1 6BT, UK., Halcox J; Swansea University Medical School, Swansea, SA2 8PP, UK., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33014, Finland.; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, 33014, Finland., Loeffler M; Institute for Medical Informatics, Statistics and Epidemiology, , University of Leipzig, Leipzig, 04107, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, 04107, Germany., Evans MK; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 20892, USA., Debette S; Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, CHU Bordeaux, F-33000, Bordeaux, France., Humphries SE; Centre for Cardiovascular Genetics, Institute Cardiovascular Science, University College London, London, WC1E 6BT, UK., Völker U; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, 17475, Germany.; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, 17475, Germany., Gudnason V; Icelandic Heart Association, Kopavogur, IS-201, Iceland.; University of Iceland, Reykjavik, 101, Iceland., Hingorani AD; Institute of Cardiovascular Science, University College London, London, WC1 6BT, UK., Björkegren JLM; Department of Genetics and Genomic Sciences, The Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. johan.bjorkegren@mssm.edu.; Clinical Gene Networks AB, Stockholm, 104 62, Sweden. johan.bjorkegren@mssm.edu.; Department of Pathophysiology, Institute of Biomedicine and Translation Medicine, University of Tartu, Biomeedikum, Tartu, 51010, Estonia. johan.bjorkegren@mssm.edu.; Integrated Cardio Metabolic Centre, Department of Medicine, Karolinska Institutet, Karolinska Universitetssjukhuset, Huddinge, SE-141 57, Sweden. johan.bjorkegren@mssm.edu., Casas JP; Institute of Health Informatics, University College London, London, WC1E 6BT, UK., O'Donnell CJ; Intramural Administration Management Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, 20892, USA. Christopher.ODonnell@va.gov.; Cardiology Section, Boston Veteran's Administration Healthcare, Boston, MA, 02130, USA. Christopher.ODonnell@va.gov.; Harvard Medical School, Boston, MA, 02115, USA. Christopher.ODonnell@va.gov. |
| Corporate Authors: | MEGASTROKE Consortium |
| Source: | Nature communications [Nat Commun] 2018 Dec 03; Vol. 9 (1), pp. 5141. Date of Electronic Publication: 2018 Dec 03. |
| Publication Type: | Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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