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NRG1 Gene Fusions Are Recurrent, Clinically Actionable Gene Rearrangements in KRAS Wild-Type Pancreatic Ductal Adenocarcinoma.

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Title: NRG1 Gene Fusions Are Recurrent, Clinically Actionable Gene Rearrangements in KRAS Wild-Type Pancreatic Ductal Adenocarcinoma.
Authors: Jones MR; BC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada., Williamson LM; BC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada., Topham JT; Pancreas Centre British Columbia, Vancouver, Canada., Lee MKC; BC Cancer, Division of Medical Oncology, Vancouver, British Columbia, Canada., Goytain A; Department of Pathology and Laboratory Medicine, Vancouver General Hospital, Vancouver, British Columbia, Canada., Ho J; Department of Pathology and Laboratory Medicine, Vancouver General Hospital, Vancouver, British Columbia, Canada., Denroche RE; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Jang G; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Pleasance E; BC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada., Shen Y; BC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada., Karasinska JM; Pancreas Centre British Columbia, Vancouver, Canada., McGhie JP; BC Cancer, Division of Medical Oncology, Vancouver, British Columbia, Canada., Gill S; BC Cancer, Division of Medical Oncology, Vancouver, British Columbia, Canada., Lim HJ; BC Cancer, Division of Medical Oncology, Vancouver, British Columbia, Canada., Moore MJ; Division of Medical Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada., Wong HL; BC Cancer, Division of Medical Oncology, Vancouver, British Columbia, Canada., Ng T; Department of Pathology and Laboratory Medicine, Vancouver General Hospital, Vancouver, British Columbia, Canada., Yip S; Department of Pathology and Laboratory Medicine, Vancouver General Hospital, Vancouver, British Columbia, Canada., Zhang W; BC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada., Sadeghi S; BC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada., Reisle C; BC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada., Mungall AJ; BC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada., Mungall KL; BC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada., Moore RA; BC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada., Ma Y; BC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada., Knox JJ; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.; Division of Medical Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada., Gallinger S; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada., Laskin J; BC Cancer, Division of Medical Oncology, Vancouver, British Columbia, Canada., Marra MA; BC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada., Schaeffer DF; Pancreas Centre British Columbia, Vancouver, Canada.; Department of Pathology and Laboratory Medicine, Vancouver General Hospital, Vancouver, British Columbia, Canada., Jones SJM; BC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Molecular Biology and Biochemistry, Simon Fraser University, Vancouver, British Columbia, Canada., Renouf DJ; Pancreas Centre British Columbia, Vancouver, Canada. drenouf@bccancer.bc.ca.; BC Cancer, Division of Medical Oncology, Vancouver, British Columbia, Canada.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2019 Aug 01; Vol. 25 (15), pp. 4674-4681. Date of Electronic Publication: 2019 May 08.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
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  Data: NRG1 Gene Fusions Are Recurrent, Clinically Actionable Gene Rearrangements in KRAS Wild-Type Pancreatic Ductal Adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Jones+MR%22">Jones MR</searchLink>; BC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Williamson+LM%22">Williamson LM</searchLink>; BC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Topham+JT%22">Topham JT</searchLink>; Pancreas Centre British Columbia, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Lee+MKC%22">Lee MKC</searchLink>; BC Cancer, Division of Medical Oncology, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Goytain+A%22">Goytain A</searchLink>; Department of Pathology and Laboratory Medicine, Vancouver General Hospital, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Ho+J%22">Ho J</searchLink>; Department of Pathology and Laboratory Medicine, Vancouver General Hospital, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Denroche+RE%22">Denroche RE</searchLink>; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Jang+G%22">Jang G</searchLink>; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Pleasance+E%22">Pleasance E</searchLink>; BC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Shen+Y%22">Shen Y</searchLink>; BC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Karasinska+JM%22">Karasinska JM</searchLink>; Pancreas Centre British Columbia, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22McGhie+JP%22">McGhie JP</searchLink>; BC Cancer, Division of Medical Oncology, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Gill+S%22">Gill S</searchLink>; BC Cancer, Division of Medical Oncology, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Lim+HJ%22">Lim HJ</searchLink>; BC Cancer, Division of Medical Oncology, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Moore+MJ%22">Moore MJ</searchLink>; Division of Medical Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Wong+HL%22">Wong HL</searchLink>; BC Cancer, Division of Medical Oncology, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Ng+T%22">Ng T</searchLink>; Department of Pathology and Laboratory Medicine, Vancouver General Hospital, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Yip+S%22">Yip S</searchLink>; Department of Pathology and Laboratory Medicine, Vancouver General Hospital, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; BC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Sadeghi+S%22">Sadeghi S</searchLink>; BC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Reisle+C%22">Reisle C</searchLink>; BC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Mungall+AJ%22">Mungall AJ</searchLink>; BC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Mungall+KL%22">Mungall KL</searchLink>; BC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Moore+RA%22">Moore RA</searchLink>; BC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Ma+Y%22">Ma Y</searchLink>; BC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Knox+JJ%22">Knox JJ</searchLink>; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.; Division of Medical Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Gallinger+S%22">Gallinger S</searchLink>; PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Laskin+J%22">Laskin J</searchLink>; BC Cancer, Division of Medical Oncology, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Marra+MA%22">Marra MA</searchLink>; BC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Schaeffer+DF%22">Schaeffer DF</searchLink>; Pancreas Centre British Columbia, Vancouver, Canada.; Department of Pathology and Laboratory Medicine, Vancouver General Hospital, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Jones+SJM%22">Jones SJM</searchLink>; BC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Molecular Biology and Biochemistry, Simon Fraser University, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Renouf+DJ%22">Renouf DJ</searchLink>; Pancreas Centre British Columbia, Vancouver, Canada. drenouf@bccancer.bc.ca.; BC Cancer, Division of Medical Oncology, Vancouver, British Columbia, Canada.
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