Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss.
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| Title: | Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss. |
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| Authors: | Fedoriw A; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Rajapurkar SR; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., O'Brien S; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Gerhart SV; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Mitchell LH; Epizyme, Inc, Cambridge, MA 02139, USA., Adams ND; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Rioux N; Epizyme, Inc, Cambridge, MA 02139, USA., Lingaraj T; Epizyme, Inc, Cambridge, MA 02139, USA., Ribich SA; Epizyme, Inc, Cambridge, MA 02139, USA., Pappalardi MB; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Shah N; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Laraio J; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Liu Y; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Butticello M; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Carpenter CL; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Creasy C; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Korenchuk S; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., McCabe MT; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., McHugh CF; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Nagarajan R; Medicinal Science and Technology, GlaxoSmithKline, Collegeville, PA 19426, USA., Wagner C; Medicinal Science and Technology, GlaxoSmithKline, Collegeville, PA 19426, USA., Zappacosta F; Medicinal Science and Technology, GlaxoSmithKline, Collegeville, PA 19426, USA., Annan R; Medicinal Science and Technology, GlaxoSmithKline, Collegeville, PA 19426, USA., Concha NO; Medicinal Science and Technology, GlaxoSmithKline, Collegeville, PA 19426, USA., Thomas RA; Nonclinical Safety Assessment, GlaxoSmithKline, Collegeville, PA 19426, USA., Hart TK; Nonclinical Safety Assessment, GlaxoSmithKline, Collegeville, PA 19426, USA., Smith JJ; Epizyme, Inc, Cambridge, MA 02139, USA., Copeland RA; Epizyme, Inc, Cambridge, MA 02139, USA., Moyer MP; Epizyme, Inc, Cambridge, MA 02139, USA., Campbell J; Epizyme, Inc, Cambridge, MA 02139, USA., Stickland K; Epizyme, Inc, Cambridge, MA 02139, USA., Mills J; Epizyme, Inc, Cambridge, MA 02139, USA., Jacques-O'Hagan S; Epizyme, Inc, Cambridge, MA 02139, USA., Allain C; Epizyme, Inc, Cambridge, MA 02139, USA., Johnston D; Epizyme, Inc, Cambridge, MA 02139, USA., Raimondi A; Epizyme, Inc, Cambridge, MA 02139, USA., Porter Scott M; Epizyme, Inc, Cambridge, MA 02139, USA., Waters N; Epizyme, Inc, Cambridge, MA 02139, USA., Swinger K; Epizyme, Inc, Cambridge, MA 02139, USA., Boriack-Sjodin A; Epizyme, Inc, Cambridge, MA 02139, USA., Riera T; Epizyme, Inc, Cambridge, MA 02139, USA., Shapiro G; Epizyme, Inc, Cambridge, MA 02139, USA., Chesworth R; Epizyme, Inc, Cambridge, MA 02139, USA., Prinjha RK; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Kruger RG; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Barbash O; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Mohammad HP; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA. Electronic address: helai.x.mohammad@gsk.com. |
| Source: | Cancer cell [Cancer Cell] 2019 Jul 08; Vol. 36 (1), pp. 100-114.e25. Date of Electronic Publication: 2019 Jun 27. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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