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Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase.

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Title: Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase.
Authors: Palmieri EM; Leukocyte Signaling Section, Cancer & Inflammation Program, National Cancer Institute, Frederick, MD, USA., Gonzalez-Cotto M; Leukocyte Signaling Section, Cancer & Inflammation Program, National Cancer Institute, Frederick, MD, USA., Baseler WA; Leukocyte Signaling Section, Cancer & Inflammation Program, National Cancer Institute, Frederick, MD, USA., Davies LC; Leukocyte Signaling Section, Cancer & Inflammation Program, National Cancer Institute, Frederick, MD, USA.; Division of Infection & Immunity, School of Medicine, Cardiff University, Tenovus Building, Heath Park, Cardiff, CF14 4XN, UK., Ghesquière B; Metabolomics Expertise Center, Vesalius Research Center, VIB, 3000, Leuven, Belgium.; Metabolomics Expertise Center, Department of Oncology, KU Leuven, 3000, Leuven, Belgium., Maio N; Molecular Medicine Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA., Rice CM; Leukocyte Signaling Section, Cancer & Inflammation Program, National Cancer Institute, Frederick, MD, USA.; School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol, BS8 1TD, UK., Rouault TA; Molecular Medicine Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA., Cassel T; Department of Toxicology and Cancer Biology and Markey Cancer Center and Center for Environmental and Systems Biochemistry, University of Kentucky, Lexington, KY, USA., Higashi RM; Department of Toxicology and Cancer Biology and Markey Cancer Center and Center for Environmental and Systems Biochemistry, University of Kentucky, Lexington, KY, USA., Lane AN; Department of Toxicology and Cancer Biology and Markey Cancer Center and Center for Environmental and Systems Biochemistry, University of Kentucky, Lexington, KY, USA., Fan TW; Department of Toxicology and Cancer Biology and Markey Cancer Center and Center for Environmental and Systems Biochemistry, University of Kentucky, Lexington, KY, USA., Wink DA; Chemical and Molecular Inflammation Section, Cancer and Inflammation Program, National Cancer Institute, Frederick, MD, USA., McVicar DW; Leukocyte Signaling Section, Cancer & Inflammation Program, National Cancer Institute, Frederick, MD, USA. mcvicard@mail.nih.gov.
Source: Nature communications [Nat Commun] 2020 Feb 04; Vol. 11 (1), pp. 698. Date of Electronic Publication: 2020 Feb 04.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase.
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  Data: <searchLink fieldCode="AU" term="%22Palmieri+EM%22">Palmieri EM</searchLink>; Leukocyte Signaling Section, Cancer & Inflammation Program, National Cancer Institute, Frederick, MD, USA.<br /><searchLink fieldCode="AU" term="%22Gonzalez-Cotto+M%22">Gonzalez-Cotto M</searchLink>; Leukocyte Signaling Section, Cancer & Inflammation Program, National Cancer Institute, Frederick, MD, USA.<br /><searchLink fieldCode="AU" term="%22Baseler+WA%22">Baseler WA</searchLink>; Leukocyte Signaling Section, Cancer & Inflammation Program, National Cancer Institute, Frederick, MD, USA.<br /><searchLink fieldCode="AU" term="%22Davies+LC%22">Davies LC</searchLink>; Leukocyte Signaling Section, Cancer & Inflammation Program, National Cancer Institute, Frederick, MD, USA.; Division of Infection & Immunity, School of Medicine, Cardiff University, Tenovus Building, Heath Park, Cardiff, CF14 4XN, UK.<br /><searchLink fieldCode="AU" term="%22Ghesquière+B%22">Ghesquière B</searchLink>; Metabolomics Expertise Center, Vesalius Research Center, VIB, 3000, Leuven, Belgium.; Metabolomics Expertise Center, Department of Oncology, KU Leuven, 3000, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Maio+N%22">Maio N</searchLink>; Molecular Medicine Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Rice+CM%22">Rice CM</searchLink>; Leukocyte Signaling Section, Cancer & Inflammation Program, National Cancer Institute, Frederick, MD, USA.; School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol, BS8 1TD, UK.<br /><searchLink fieldCode="AU" term="%22Rouault+TA%22">Rouault TA</searchLink>; Molecular Medicine Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Cassel+T%22">Cassel T</searchLink>; Department of Toxicology and Cancer Biology and Markey Cancer Center and Center for Environmental and Systems Biochemistry, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Higashi+RM%22">Higashi RM</searchLink>; Department of Toxicology and Cancer Biology and Markey Cancer Center and Center for Environmental and Systems Biochemistry, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Lane+AN%22">Lane AN</searchLink>; Department of Toxicology and Cancer Biology and Markey Cancer Center and Center for Environmental and Systems Biochemistry, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Fan+TW%22">Fan TW</searchLink>; Department of Toxicology and Cancer Biology and Markey Cancer Center and Center for Environmental and Systems Biochemistry, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Wink+DA%22">Wink DA</searchLink>; Chemical and Molecular Inflammation Section, Cancer and Inflammation Program, National Cancer Institute, Frederick, MD, USA.<br /><searchLink fieldCode="AU" term="%22McVicar+DW%22">McVicar DW</searchLink>; Leukocyte Signaling Section, Cancer & Inflammation Program, National Cancer Institute, Frederick, MD, USA. mcvicard@mail.nih.gov.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2020 Feb 04; Vol. 11 (1), pp. 698. <i>Date of Electronic Publication: </i>2020 Feb 04.
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