DNA-Encoded Library Technology-Based Discovery, Lead Optimization, and Prodrug Strategy toward Structurally Unique Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors.
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| Title: | DNA-Encoded Library Technology-Based Discovery, Lead Optimization, and Prodrug Strategy toward Structurally Unique Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors. |
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| Authors: | Kazmierski WM; HIV Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, Durham, North Carolina 27709, United States., Xia B; Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GSK, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Miller J; HIV Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, Durham, North Carolina 27709, United States., De la Rosa M; HIV Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, Durham, North Carolina 27709, United States., Favre D; HIV Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, Durham, North Carolina 27709, United States., Dunham RM; HIV Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, Durham, North Carolina 27709, United States., Washio Y; MST Medicine Design, Medicinal Chemistry, GlaxoSmithKline, Gunnels Wood Rd, Stevenage SG1 2NY, U.K., Zhu Z; Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GSK, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Wang F; DMPK/IVIVT, GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, Pennsylvania 19426-0989, United States., Mebrahtu M; Screening, Profiling & Mechanistic Biology, RD Platform Technology & Science, GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, Pennsylvania 19426-0989, United States., Deng H; Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GSK, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Basilla J; Screening, Profiling & Mechanistic Biology, RD Platform Technology & Science, GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, Pennsylvania 19426-0989, United States., Wang L; Drug Design and Selection, GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, Pennsylvania 19426, United States., Evindar G; Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GSK, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Fan L; Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GSK, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Olszewski A; Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GSK, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Prabhu N; Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GSK, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Davie C; Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GSK, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Messer JA; Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GSK, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Samano V; HIV Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, Durham, North Carolina 27709, United States. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2020 Apr 09; Vol. 63 (7), pp. 3552-3562. Date of Electronic Publication: 2020 Mar 19. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 32073266 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: DNA-Encoded Library Technology-Based Discovery, Lead Optimization, and Prodrug Strategy toward Structurally Unique Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Kazmierski+WM%22">Kazmierski WM</searchLink>; HIV Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, Durham, North Carolina 27709, United States.<br /><searchLink fieldCode="AU" term="%22Xia+B%22">Xia B</searchLink>; Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GSK, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States.<br /><searchLink fieldCode="AU" term="%22Miller+J%22">Miller J</searchLink>; HIV Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, Durham, North Carolina 27709, United States.<br /><searchLink fieldCode="AU" term="%22De+la+Rosa+M%22">De la Rosa M</searchLink>; HIV Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, Durham, North Carolina 27709, United States.<br /><searchLink fieldCode="AU" term="%22Favre+D%22">Favre D</searchLink>; HIV Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, Durham, North Carolina 27709, United States.<br /><searchLink fieldCode="AU" term="%22Dunham+RM%22">Dunham RM</searchLink>; HIV Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, Durham, North Carolina 27709, United States.<br /><searchLink fieldCode="AU" term="%22Washio+Y%22">Washio Y</searchLink>; MST Medicine Design, Medicinal Chemistry, GlaxoSmithKline, Gunnels Wood Rd, Stevenage SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Zhu+Z%22">Zhu Z</searchLink>; Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GSK, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States.<br /><searchLink fieldCode="AU" term="%22Wang+F%22">Wang F</searchLink>; DMPK/IVIVT, GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, Pennsylvania 19426-0989, United States.<br /><searchLink fieldCode="AU" term="%22Mebrahtu+M%22">Mebrahtu M</searchLink>; Screening, Profiling & Mechanistic Biology, RD Platform Technology & Science, GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, Pennsylvania 19426-0989, United States.<br /><searchLink fieldCode="AU" term="%22Deng+H%22">Deng H</searchLink>; Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GSK, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States.<br /><searchLink fieldCode="AU" term="%22Basilla+J%22">Basilla J</searchLink>; Screening, Profiling & Mechanistic Biology, RD Platform Technology & Science, GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, Pennsylvania 19426-0989, United States.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Drug Design and Selection, GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, Pennsylvania 19426, United States.<br /><searchLink fieldCode="AU" term="%22Evindar+G%22">Evindar G</searchLink>; Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GSK, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States.<br /><searchLink fieldCode="AU" term="%22Fan+L%22">Fan L</searchLink>; Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GSK, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States.<br /><searchLink fieldCode="AU" term="%22Olszewski+A%22">Olszewski A</searchLink>; Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GSK, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States.<br /><searchLink fieldCode="AU" term="%22Prabhu+N%22">Prabhu N</searchLink>; Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GSK, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States.<br /><searchLink fieldCode="AU" term="%22Davie+C%22">Davie C</searchLink>; Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GSK, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States.<br /><searchLink fieldCode="AU" term="%22Messer+JA%22">Messer JA</searchLink>; Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GSK, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States.<br /><searchLink fieldCode="AU" term="%22Samano+V%22">Samano V</searchLink>; HIV Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, Durham, North Carolina 27709, United States. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2020 Apr 09; Vol. 63 (7), pp. 3552-3562. <i>Date of Electronic Publication: </i>2020 Mar 19. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=32073266 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1021/acs.jmedchem.9b01799 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 3552 Titles: – TitleFull: DNA-Encoded Library Technology-Based Discovery, Lead Optimization, and Prodrug Strategy toward Structurally Unique Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kazmierski WM – PersonEntity: Name: NameFull: Xia B – PersonEntity: Name: NameFull: Miller J – PersonEntity: Name: NameFull: De la Rosa M – PersonEntity: Name: NameFull: Favre D – PersonEntity: Name: NameFull: Dunham RM – PersonEntity: Name: NameFull: Washio Y – PersonEntity: Name: NameFull: Zhu Z – PersonEntity: Name: NameFull: Wang F – PersonEntity: Name: NameFull: Mebrahtu M – PersonEntity: Name: NameFull: Deng H – PersonEntity: Name: NameFull: Basilla J – PersonEntity: Name: NameFull: Wang L – PersonEntity: Name: NameFull: Evindar G – PersonEntity: Name: NameFull: Fan L – PersonEntity: Name: NameFull: Olszewski A – PersonEntity: Name: NameFull: Prabhu N – PersonEntity: Name: NameFull: Davie C – PersonEntity: Name: NameFull: Messer JA – PersonEntity: Name: NameFull: Samano V IsPartOfRelationships: – BibEntity: Dates: – D: 09 M: 04 Text: 2020 Apr 09 Type: published Y: 2020 Identifiers: – Type: issn-electronic Value: 1520-4804 Numbering: – Type: volume Value: 63 – Type: issue Value: 7 Titles: – TitleFull: Journal of medicinal chemistry Type: main |
| ResultId | 1 |
