DNA-Encoded Library Technology-Based Discovery, Lead Optimization, and Prodrug Strategy toward Structurally Unique Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors.
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| Title: | DNA-Encoded Library Technology-Based Discovery, Lead Optimization, and Prodrug Strategy toward Structurally Unique Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors. |
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| Authors: | Kazmierski WM; HIV Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, Durham, North Carolina 27709, United States., Xia B; Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GSK, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Miller J; HIV Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, Durham, North Carolina 27709, United States., De la Rosa M; HIV Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, Durham, North Carolina 27709, United States., Favre D; HIV Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, Durham, North Carolina 27709, United States., Dunham RM; HIV Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, Durham, North Carolina 27709, United States., Washio Y; MST Medicine Design, Medicinal Chemistry, GlaxoSmithKline, Gunnels Wood Rd, Stevenage SG1 2NY, U.K., Zhu Z; Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GSK, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Wang F; DMPK/IVIVT, GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, Pennsylvania 19426-0989, United States., Mebrahtu M; Screening, Profiling & Mechanistic Biology, RD Platform Technology & Science, GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, Pennsylvania 19426-0989, United States., Deng H; Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GSK, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Basilla J; Screening, Profiling & Mechanistic Biology, RD Platform Technology & Science, GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, Pennsylvania 19426-0989, United States., Wang L; Drug Design and Selection, GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, Pennsylvania 19426, United States., Evindar G; Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GSK, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Fan L; Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GSK, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Olszewski A; Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GSK, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Prabhu N; Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GSK, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Davie C; Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GSK, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Messer JA; Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GSK, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Samano V; HIV Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, Durham, North Carolina 27709, United States. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2020 Apr 09; Vol. 63 (7), pp. 3552-3562. Date of Electronic Publication: 2020 Mar 19. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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