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Exploring the SAR of the β-Ketoacyl-ACP Synthase Inhibitor GSK3011724A and Optimization around a Genotoxic Metabolite.

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Title: Exploring the SAR of the β-Ketoacyl-ACP Synthase Inhibitor GSK3011724A and Optimization around a Genotoxic Metabolite.
Authors: Cunningham F; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain., Esquivias J; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain., Fernández-Menéndez R; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain., Pérez A; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain., Guardia A; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain., Escribano J; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain., Rivero C; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain., Vimal M; GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, U.K., Cacho M; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain., de Dios-Antón P; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain., Martínez-Martínez MS; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain., Jiménez E; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain., Huertas Valentín L; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain., Rebollo-López MJ; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain., López-Román EM; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain., Sousa-Morcuende V; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain., Rullas J; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain., Neu M; GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, U.K., Chung CW; GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, U.K., Bates RH; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
Source: ACS infectious diseases [ACS Infect Dis] 2020 May 08; Vol. 6 (5), pp. 1098-1109. Date of Electronic Publication: 2020 Mar 20.
Publication Type: Journal Article
Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Cunningham+F%22">Cunningham F</searchLink>; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Esquivias+J%22">Esquivias J</searchLink>; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Fernández-Menéndez+R%22">Fernández-Menéndez R</searchLink>; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Pérez+A%22">Pérez A</searchLink>; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Guardia+A%22">Guardia A</searchLink>; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Escribano+J%22">Escribano J</searchLink>; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Rivero+C%22">Rivero C</searchLink>; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Vimal+M%22">Vimal M</searchLink>; GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Cacho+M%22">Cacho M</searchLink>; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22de+Dios-Antón+P%22">de Dios-Antón P</searchLink>; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Martínez-Martínez+MS%22">Martínez-Martínez MS</searchLink>; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Jiménez+E%22">Jiménez E</searchLink>; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Huertas+Valentín+L%22">Huertas Valentín L</searchLink>; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Rebollo-López+MJ%22">Rebollo-López MJ</searchLink>; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22López-Román+EM%22">López-Román EM</searchLink>; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Sousa-Morcuende+V%22">Sousa-Morcuende V</searchLink>; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Rullas+J%22">Rullas J</searchLink>; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Neu+M%22">Neu M</searchLink>; GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Chung+CW%22">Chung CW</searchLink>; GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Bates+RH%22">Bates RH</searchLink>; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
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