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Combination immunotherapy with anti-PD-L1 antibody and depletion of regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology.

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Title: Combination immunotherapy with anti-PD-L1 antibody and depletion of regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology.
Authors: David P; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Drabczyk-Pluta M; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Pastille E; Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Knuschke T; Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Werner T; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Honke N; Department of Rheumatology, Hiller Research Center Rheumatology, University Hospital Düsseldorf, Germany., Megger DA; Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany., Akhmetzyanova I; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.; Department of Pathology, Albert Einstein College of Medicine, New York, New York, United States of America., Shaabani N; Institute of Immunology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Eyking-Singer A; Department of Gastroenterology and Hepatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Cario E; Department of Gastroenterology and Hepatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Kershaw O; Department of Veterinary Medicine, Institute of Veterinary Pathology, Free University Berlin, Berlin, Germany., Gruber AD; Department of Veterinary Medicine, Institute of Veterinary Pathology, Free University Berlin, Berlin, Germany., Tenbusch M; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany., Dietze KK; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Trilling M; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Liu J; Department of Infectious Diseases, Union Hospital of Tonji Medical College, Huazhong University of Science and Technology, Wuhan, China., Schadendorf D; Department of Dermatology, Comprehensive Cancer Center, University Hospital Essen, Essen, Germany., Streeck H; Institute for HIV Research, University Hospital Essen, University Duisburg-Essen, Essen, Germany., Lang KS; Institute of Immunology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Xie Y; Key Lab of Molecular Virology, Shanghai Medical College, Fudan University, Shanghai, China., Zimmer L; Department of Dermatology, Comprehensive Cancer Center, University Hospital Essen, Essen, Germany., Sitek B; Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany., Paschen A; Department of Dermatology, Comprehensive Cancer Center, University Hospital Essen, Essen, Germany., Westendorf AM; Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Dittmer U; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Zelinskyy G; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Source: PLoS pathogens [PLoS Pathog] 2020 Mar 30; Vol. 16 (3), pp. e1008340. Date of Electronic Publication: 2020 Mar 30 (Print Publication: 2020).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Combination immunotherapy with anti-PD-L1 antibody and depletion of regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology.
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  Data: <searchLink fieldCode="AU" term="%22David+P%22">David P</searchLink>; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Drabczyk-Pluta+M%22">Drabczyk-Pluta M</searchLink>; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Pastille+E%22">Pastille E</searchLink>; Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Knuschke+T%22">Knuschke T</searchLink>; Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Werner+T%22">Werner T</searchLink>; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Honke+N%22">Honke N</searchLink>; Department of Rheumatology, Hiller Research Center Rheumatology, University Hospital Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Megger+DA%22">Megger DA</searchLink>; Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Akhmetzyanova+I%22">Akhmetzyanova I</searchLink>; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.; Department of Pathology, Albert Einstein College of Medicine, New York, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Shaabani+N%22">Shaabani N</searchLink>; Institute of Immunology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Eyking-Singer+A%22">Eyking-Singer A</searchLink>; Department of Gastroenterology and Hepatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Cario+E%22">Cario E</searchLink>; Department of Gastroenterology and Hepatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Kershaw+O%22">Kershaw O</searchLink>; Department of Veterinary Medicine, Institute of Veterinary Pathology, Free University Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Gruber+AD%22">Gruber AD</searchLink>; Department of Veterinary Medicine, Institute of Veterinary Pathology, Free University Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Tenbusch+M%22">Tenbusch M</searchLink>; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Dietze+KK%22">Dietze KK</searchLink>; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Trilling+M%22">Trilling M</searchLink>; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Department of Infectious Diseases, Union Hospital of Tonji Medical College, Huazhong University of Science and Technology, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Schadendorf+D%22">Schadendorf D</searchLink>; Department of Dermatology, Comprehensive Cancer Center, University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Streeck+H%22">Streeck H</searchLink>; Institute for HIV Research, University Hospital Essen, University Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Lang+KS%22">Lang KS</searchLink>; Institute of Immunology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Xie+Y%22">Xie Y</searchLink>; Key Lab of Molecular Virology, Shanghai Medical College, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zimmer+L%22">Zimmer L</searchLink>; Department of Dermatology, Comprehensive Cancer Center, University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Sitek+B%22">Sitek B</searchLink>; Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Paschen+A%22">Paschen A</searchLink>; Department of Dermatology, Comprehensive Cancer Center, University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Westendorf+AM%22">Westendorf AM</searchLink>; Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Dittmer+U%22">Dittmer U</searchLink>; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Zelinskyy+G%22">Zelinskyy G</searchLink>; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
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