Combination immunotherapy with anti-PD-L1 antibody and depletion of regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology.
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| Title: | Combination immunotherapy with anti-PD-L1 antibody and depletion of regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology. |
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| Authors: | David P; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Drabczyk-Pluta M; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Pastille E; Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Knuschke T; Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Werner T; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Honke N; Department of Rheumatology, Hiller Research Center Rheumatology, University Hospital Düsseldorf, Germany., Megger DA; Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany., Akhmetzyanova I; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.; Department of Pathology, Albert Einstein College of Medicine, New York, New York, United States of America., Shaabani N; Institute of Immunology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Eyking-Singer A; Department of Gastroenterology and Hepatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Cario E; Department of Gastroenterology and Hepatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Kershaw O; Department of Veterinary Medicine, Institute of Veterinary Pathology, Free University Berlin, Berlin, Germany., Gruber AD; Department of Veterinary Medicine, Institute of Veterinary Pathology, Free University Berlin, Berlin, Germany., Tenbusch M; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany., Dietze KK; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Trilling M; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Liu J; Department of Infectious Diseases, Union Hospital of Tonji Medical College, Huazhong University of Science and Technology, Wuhan, China., Schadendorf D; Department of Dermatology, Comprehensive Cancer Center, University Hospital Essen, Essen, Germany., Streeck H; Institute for HIV Research, University Hospital Essen, University Duisburg-Essen, Essen, Germany., Lang KS; Institute of Immunology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Xie Y; Key Lab of Molecular Virology, Shanghai Medical College, Fudan University, Shanghai, China., Zimmer L; Department of Dermatology, Comprehensive Cancer Center, University Hospital Essen, Essen, Germany., Sitek B; Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany., Paschen A; Department of Dermatology, Comprehensive Cancer Center, University Hospital Essen, Essen, Germany., Westendorf AM; Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Dittmer U; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Zelinskyy G; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. |
| Source: | PLoS pathogens [PLoS Pathog] 2020 Mar 30; Vol. 16 (3), pp. e1008340. Date of Electronic Publication: 2020 Mar 30 (Print Publication: 2020). |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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