Pediatric bithalamic gliomas have a distinct epigenetic signature and frequent EGFR exon 20 insertions resulting in potential sensitivity to targeted kinase inhibition. - Mondal G; Lee JC; Ravindranathan A; Villanueva-Meyer JE; Tran QT; Allen SJ; Barreto J; Gupta R; Doo P; Van Ziffle J; Onodera C; Devine P; et al. (Acta neuropathologica, 2020)