A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells.
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| Title: | A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells. |
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| Authors: | Wakita M; Research Institute for Microbial Diseases (RIMD), Osaka University, Suita, 565-0871, Japan., Takahashi A; Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, 135-8550, Japan., Sano O; BioMolecular Research Laboratories, Takeda Pharmaceutical Company Ltd., Fujisawa, 251-8555, Japan., Loo TM; Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, 135-8550, Japan., Imai Y; Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, 135-8550, Japan., Narukawa M; Research Institute for Microbial Diseases (RIMD), Osaka University, Suita, 565-0871, Japan., Iwata H; BioMolecular Research Laboratories, Takeda Pharmaceutical Company Ltd., Fujisawa, 251-8555, Japan., Matsudaira T; Research Institute for Microbial Diseases (RIMD), Osaka University, Suita, 565-0871, Japan.; Immunology Frontier Research Center (IFReC), Osaka University, Suita, 565-0871, Japan., Kawamoto S; Research Institute for Microbial Diseases (RIMD), Osaka University, Suita, 565-0871, Japan., Ohtani N; Graduate School of Medicine, Osaka City University, Osaka, 545-8585, Japan., Yoshimori T; Graduate School of Medicine, Osaka University, Suita, 565-0871, Japan., Hara E; Research Institute for Microbial Diseases (RIMD), Osaka University, Suita, 565-0871, Japan. ehara@biken.osaka-u.ac.jp.; Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, 135-8550, Japan. ehara@biken.osaka-u.ac.jp.; Immunology Frontier Research Center (IFReC), Osaka University, Suita, 565-0871, Japan. ehara@biken.osaka-u.ac.jp. |
| Source: | Nature communications [Nat Commun] 2020 Apr 22; Vol. 11 (1), pp. 1935. Date of Electronic Publication: 2020 Apr 22. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-020-15719-6 |
