The human tumor microbiome is composed of tumor type-specific intracellular bacteria.

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Title: The human tumor microbiome is composed of tumor type-specific intracellular bacteria.
Authors: Nejman D; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Livyatan I; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel., Fuks G; Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel., Gavert N; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Zwang Y; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Geller LT; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Rotter-Maskowitz A; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Weiser R; Division of Surgery, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel., Mallel G; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Gigi E; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Meltser A; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Douglas GM; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada., Kamer I; Institute of Oncology, Sheba Medical Center, Ramat Gan, Israel., Gopalakrishnan V; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Dadosh T; Department of Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel., Levin-Zaidman S; Department of Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel., Avnet S; Orthopaedic Pathophysiology and Regenerative Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Atlan T; Department of Bioinformatics, Jerusalem College of Technology, Jerusalem, Israel., Cooper ZA; Translational Medicine, Oncology R&D, AstraZeneca, Gaithersburg, MD, USA., Arora R; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Cogdill AP; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Khan MAW; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ologun G; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Bussi Y; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Weinberger A; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel., Lotan-Pompan M; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel., Golani O; Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel., Perry G; Cancer Research Center, Sheba Medical Center, Ramat Gan, Israel., Rokah M; Department of Thoracic Surgery, Sheba Medical Center, Ramat Gan, Israel., Bahar-Shany K; Cancer Research Center, Sheba Medical Center, Ramat Gan, Israel., Rozeman EA; Department of Medical Oncology and Division of Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands., Blank CU; Department of Medical Oncology and Division of Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands., Ronai A; Pediatric Gastroenterology Institute, Rambam Medical Center, Haifa, Israel., Shaoul R; Pediatric Gastroenterology Institute, Rambam Medical Center, Haifa, Israel., Amit A; Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.; Department of Obstetrics and Gynecology, Rambam Health Care Campus, Haifa, Israel., Dorfman T; Division of General Surgery, Rambam Health Care Campus, Haifa, Israel.; Ambulatory and Breast Surgery Service, Rambam Health Care Campus, Haifa, Israel., Kremer R; Department of Thoracic Surgery, Rambam Health Care Campus, Haifa, Israel., Cohen ZR; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.; Department of Neurosurgery, Sheba Medical Center, Ramat Gan, Israel., Harnof S; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.; Department of Neurosurgery, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel., Siegal T; Neuro-Oncology Unit, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel., Yehuda-Shnaidman E; Institute of Pathology, Megalab, Maccabi Healthcare Services, Rehovot, Israel., Gal-Yam EN; Breast Oncology Institute, Sheba Medical Center, Ramat Gan, Israel., Shapira H; Institute of Pathology, Megalab, Maccabi Healthcare Services, Rehovot, Israel., Baldini N; Orthopaedic Pathophysiology and Regenerative Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy., Langille MGI; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.; Department of Pharmacology, Dalhousie University, Halifax, NS, Canada., Ben-Nun A; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.; Department of Thoracic Surgery, Sheba Medical Center, Ramat Gan, Israel., Kaufman B; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.; Institute of Oncology, Sheba Medical Center, Ramat Gan, Israel., Nissan A; Department of Surgical Oncology (Surgery C), Sheba Medical Center, Ramat Gan, Israel., Golan T; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.; Institute of Oncology, Sheba Medical Center, Ramat Gan, Israel., Dadiani M; Cancer Research Center, Sheba Medical Center, Ramat Gan, Israel., Levanon K; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.; Cancer Research Center, Sheba Medical Center, Ramat Gan, Israel., Bar J; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.; Institute of Oncology, Sheba Medical Center, Ramat Gan, Israel., Yust-Katz S; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.; Neuro-Oncology Unit, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel., Barshack I; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.; Department of Pathology, Sheba Medical Center, Ramat Gan, Israel., Peeper DS; Division of Molecular Oncology & Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands., Raz DJ; Division of Thoracic Surgery, City of Hope Medical Center, Duarte, CA, USA., Segal E; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel., Wargo JA; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Sandbank J; Institute of Pathology, Megalab, Maccabi Healthcare Services, Rehovot, Israel., Shental N; Department of Mathematics and Computer Science, The Open University of Israel, Ra'anana, Israel., Straussman R; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. ravidst@weizmann.ac.il.
Source: Science (New York, N.Y.) [Science] 2020 May 29; Vol. 368 (6494), pp. 973-980.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1095-9203
DOI:10.1126/science.aay9189