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Evaluation of the efficacy and safety of deferiprone compared with deferasirox in paediatric patients with transfusion-dependent haemoglobinopathies (DEEP-2): a multicentre, randomised, open-label, non-inferiority, phase 3 trial.

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Title: Evaluation of the efficacy and safety of deferiprone compared with deferasirox in paediatric patients with transfusion-dependent haemoglobinopathies (DEEP-2): a multicentre, randomised, open-label, non-inferiority, phase 3 trial.
Authors: Maggio A; Department of Hematology and Rare Diseases, V Cervello, Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy. Electronic address: aurelio.maggio@villasofia.it., Kattamis A; First Department of Pediatrics, National and Kapodistriam University of Athens, Athens, Greece., Felisi M; Consorzio per Valutazioni Biologiche e Farmacologiche, Bari-Pavia, Italy., Reggiardo G; Biostatistics and Data Management Unit, Medi Service, Genoa, Italy., El-Beshlawy A; Pediatric Hospital, Cairo University, Cairo, Egypt., Bejaoui M; Pediatrics and Bone Marrow Transplantation Centre, Tunis, Tunisia., Sherief L; Pediatrics Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Christou S; Thalassaemia Center, Hospital Archbishop Makarios III, Nicosia, Cyprus., Cosmi C; Clinica Pediatrica, Azienda Ospedaliero Universitaria (AOU) Sassari, Sassari, Italy., Della Pasqua O; Clinical Pharmacology and Therapeutics Group, University College London, London, UK., Del Vecchio GC; UO Pediatrica B Trambusti, AOU Consorziale Policlinico-Giovanni XXIII, Bari, Italy., Filosa A; UOSD Malattie rare del globulo rosso, AORN A Cardarelli, Napoli, Italy., Cuccia L; UOC Ematologia con Talassemia, Dipartimento di Medicina, AO Civico Di Cristina-Benfratelli, Palermo, Italy., Hassab H; Department of Pediatrics and Clinical Research Center, Faculty of Medicine, Alexandria University, Alexandria, Egypt., Kreka M; Pediatrics Department, University Hospital Center Mother Teresa, Tirana, Albania., Origa R; DH Talassemia, Ospedale Pediatrico Microcitemico A CAO, AO G Brotzu, Cagliari, Italy., Putti MC; Department of Women's and Child's Health (DSDB), University Hospital, Padova, Italy., Spino M; ApoPharma, Toronto, ON, Canada., Telfer P; Centre for Genomics and Child Health, Blizard Institute, Queen Mary University of London, London, UK., Tempesta B; Consorzio per Valutazioni Biologiche e Farmacologiche, Bari-Pavia, Italy., Vitrano A; Department of Hematology and Rare Diseases, V Cervello, Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy., Tsang YC; ApoPharma, Toronto, ON, Canada., Zaka A; Center of Thalassemia, Hospital Ihsan Cabej, Lushnje, Albania., Tricta F; ApoPharma, Toronto, ON, Canada., Bonifazi D; Consorzio per Valutazioni Biologiche e Farmacologiche, Bari-Pavia, Italy., Ceci A; Fondazione per la Ricerca Farmacologica Gianni Benzi Onlus, Valenzano, Italy.
Source: The Lancet. Haematology [Lancet Haematol] 2020 Jun; Vol. 7 (6), pp. e469-e478.
Publication Type: Clinical Trial, Phase III; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Equivalence Trial
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101643584 Publication Model: Print Cited Medium: Internet ISSN: 2352-3026 (Electronic) Linking ISSN: 23523026 NLM ISO Abbreviation: Lancet Haematol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Evaluation of the efficacy and safety of deferiprone compared with deferasirox in paediatric patients with transfusion-dependent haemoglobinopathies (DEEP-2): a multicentre, randomised, open-label, non-inferiority, phase 3 trial.
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  Data: <searchLink fieldCode="AU" term="%22Maggio+A%22">Maggio A</searchLink>; Department of Hematology and Rare Diseases, V Cervello, Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy. Electronic address: aurelio.maggio@villasofia.it.<br /><searchLink fieldCode="AU" term="%22Kattamis+A%22">Kattamis A</searchLink>; First Department of Pediatrics, National and Kapodistriam University of Athens, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Felisi+M%22">Felisi M</searchLink>; Consorzio per Valutazioni Biologiche e Farmacologiche, Bari-Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Reggiardo+G%22">Reggiardo G</searchLink>; Biostatistics and Data Management Unit, Medi Service, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22El-Beshlawy+A%22">El-Beshlawy A</searchLink>; Pediatric Hospital, Cairo University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Bejaoui+M%22">Bejaoui M</searchLink>; Pediatrics and Bone Marrow Transplantation Centre, Tunis, Tunisia.<br /><searchLink fieldCode="AU" term="%22Sherief+L%22">Sherief L</searchLink>; Pediatrics Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.<br /><searchLink fieldCode="AU" term="%22Christou+S%22">Christou S</searchLink>; Thalassaemia Center, Hospital Archbishop Makarios III, Nicosia, Cyprus.<br /><searchLink fieldCode="AU" term="%22Cosmi+C%22">Cosmi C</searchLink>; Clinica Pediatrica, Azienda Ospedaliero Universitaria (AOU) Sassari, Sassari, Italy.<br /><searchLink fieldCode="AU" term="%22Della+Pasqua+O%22">Della Pasqua O</searchLink>; Clinical Pharmacology and Therapeutics Group, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Del+Vecchio+GC%22">Del Vecchio GC</searchLink>; UO Pediatrica B Trambusti, AOU Consorziale Policlinico-Giovanni XXIII, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Filosa+A%22">Filosa A</searchLink>; UOSD Malattie rare del globulo rosso, AORN A Cardarelli, Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Cuccia+L%22">Cuccia L</searchLink>; UOC Ematologia con Talassemia, Dipartimento di Medicina, AO Civico Di Cristina-Benfratelli, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Hassab+H%22">Hassab H</searchLink>; Department of Pediatrics and Clinical Research Center, Faculty of Medicine, Alexandria University, Alexandria, Egypt.<br /><searchLink fieldCode="AU" term="%22Kreka+M%22">Kreka M</searchLink>; Pediatrics Department, University Hospital Center Mother Teresa, Tirana, Albania.<br /><searchLink fieldCode="AU" term="%22Origa+R%22">Origa R</searchLink>; DH Talassemia, Ospedale Pediatrico Microcitemico A CAO, AO G Brotzu, Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Putti+MC%22">Putti MC</searchLink>; Department of Women's and Child's Health (DSDB), University Hospital, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Spino+M%22">Spino M</searchLink>; ApoPharma, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Telfer+P%22">Telfer P</searchLink>; Centre for Genomics and Child Health, Blizard Institute, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Tempesta+B%22">Tempesta B</searchLink>; Consorzio per Valutazioni Biologiche e Farmacologiche, Bari-Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Vitrano+A%22">Vitrano A</searchLink>; Department of Hematology and Rare Diseases, V Cervello, Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Tsang+YC%22">Tsang YC</searchLink>; ApoPharma, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Zaka+A%22">Zaka A</searchLink>; Center of Thalassemia, Hospital Ihsan Cabej, Lushnje, Albania.<br /><searchLink fieldCode="AU" term="%22Tricta+F%22">Tricta F</searchLink>; ApoPharma, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Bonifazi+D%22">Bonifazi D</searchLink>; Consorzio per Valutazioni Biologiche e Farmacologiche, Bari-Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Ceci+A%22">Ceci A</searchLink>; Fondazione per la Ricerca Farmacologica Gianni Benzi Onlus, Valenzano, Italy.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Ltd%22">Elsevier Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101643584 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2352-3026 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223523026%22">23523026 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Haematol <i>Subsets: </i>MEDLINE
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