Evaluation of the efficacy and safety of deferiprone compared with deferasirox in paediatric patients with transfusion-dependent haemoglobinopathies (DEEP-2): a multicentre, randomised, open-label, non-inferiority, phase 3 trial.
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| Title: | Evaluation of the efficacy and safety of deferiprone compared with deferasirox in paediatric patients with transfusion-dependent haemoglobinopathies (DEEP-2): a multicentre, randomised, open-label, non-inferiority, phase 3 trial. |
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| Authors: | Maggio A; Department of Hematology and Rare Diseases, V Cervello, Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy. Electronic address: aurelio.maggio@villasofia.it., Kattamis A; First Department of Pediatrics, National and Kapodistriam University of Athens, Athens, Greece., Felisi M; Consorzio per Valutazioni Biologiche e Farmacologiche, Bari-Pavia, Italy., Reggiardo G; Biostatistics and Data Management Unit, Medi Service, Genoa, Italy., El-Beshlawy A; Pediatric Hospital, Cairo University, Cairo, Egypt., Bejaoui M; Pediatrics and Bone Marrow Transplantation Centre, Tunis, Tunisia., Sherief L; Pediatrics Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Christou S; Thalassaemia Center, Hospital Archbishop Makarios III, Nicosia, Cyprus., Cosmi C; Clinica Pediatrica, Azienda Ospedaliero Universitaria (AOU) Sassari, Sassari, Italy., Della Pasqua O; Clinical Pharmacology and Therapeutics Group, University College London, London, UK., Del Vecchio GC; UO Pediatrica B Trambusti, AOU Consorziale Policlinico-Giovanni XXIII, Bari, Italy., Filosa A; UOSD Malattie rare del globulo rosso, AORN A Cardarelli, Napoli, Italy., Cuccia L; UOC Ematologia con Talassemia, Dipartimento di Medicina, AO Civico Di Cristina-Benfratelli, Palermo, Italy., Hassab H; Department of Pediatrics and Clinical Research Center, Faculty of Medicine, Alexandria University, Alexandria, Egypt., Kreka M; Pediatrics Department, University Hospital Center Mother Teresa, Tirana, Albania., Origa R; DH Talassemia, Ospedale Pediatrico Microcitemico A CAO, AO G Brotzu, Cagliari, Italy., Putti MC; Department of Women's and Child's Health (DSDB), University Hospital, Padova, Italy., Spino M; ApoPharma, Toronto, ON, Canada., Telfer P; Centre for Genomics and Child Health, Blizard Institute, Queen Mary University of London, London, UK., Tempesta B; Consorzio per Valutazioni Biologiche e Farmacologiche, Bari-Pavia, Italy., Vitrano A; Department of Hematology and Rare Diseases, V Cervello, Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy., Tsang YC; ApoPharma, Toronto, ON, Canada., Zaka A; Center of Thalassemia, Hospital Ihsan Cabej, Lushnje, Albania., Tricta F; ApoPharma, Toronto, ON, Canada., Bonifazi D; Consorzio per Valutazioni Biologiche e Farmacologiche, Bari-Pavia, Italy., Ceci A; Fondazione per la Ricerca Farmacologica Gianni Benzi Onlus, Valenzano, Italy. |
| Source: | The Lancet. Haematology [Lancet Haematol] 2020 Jun; Vol. 7 (6), pp. e469-e478. |
| Publication Type: | Clinical Trial, Phase III; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Equivalence Trial |
| Journal Info: | Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101643584 Publication Model: Print Cited Medium: Internet ISSN: 2352-3026 (Electronic) Linking ISSN: 23523026 NLM ISO Abbreviation: Lancet Haematol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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