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Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits.

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Title: Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits.
Authors: Bretherick AD; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom., Canela-Xandri O; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom.; The Roslin Institute, University of Edinburgh, Easter Bush, Edinburgh, Scotland, United Kingdom., Joshi PK; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, Scotland, United Kingdom., Clark DW; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, Scotland, United Kingdom., Rawlik K; The Roslin Institute, University of Edinburgh, Easter Bush, Edinburgh, Scotland, United Kingdom., Boutin TS; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom., Zeng Y; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom.; Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.; Guangdong Province Translational Forensic Medicine Engineering Technology Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.; Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China., Amador C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom., Navarro P; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom., Rudan I; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, Scotland, United Kingdom., Wright AF; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom., Campbell H; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, Scotland, United Kingdom., Vitart V; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom., Wilson JF; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom.; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, Scotland, United Kingdom., Tenesa A; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom.; The Roslin Institute, University of Edinburgh, Easter Bush, Edinburgh, Scotland, United Kingdom., Ponting CP; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom., Baillie JK; The Roslin Institute, University of Edinburgh, Easter Bush, Edinburgh, Scotland, United Kingdom., Haley C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom.; The Roslin Institute, University of Edinburgh, Easter Bush, Edinburgh, Scotland, United Kingdom.
Source: PLoS genetics [PLoS Genet] 2020 Jul 06; Vol. 16 (7), pp. e1008785. Date of Electronic Publication: 2020 Jul 06 (Print Publication: 2020).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7404 (Electronic) Linking ISSN: 15537390 NLM ISO Abbreviation: PLoS Genet Subsets: MEDLINE
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  Data: Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits.
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  Data: <searchLink fieldCode="AU" term="%22Bretherick+AD%22">Bretherick AD</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Canela-Xandri+O%22">Canela-Xandri O</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom.; The Roslin Institute, University of Edinburgh, Easter Bush, Edinburgh, Scotland, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Joshi+PK%22">Joshi PK</searchLink>; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, Scotland, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Clark+DW%22">Clark DW</searchLink>; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, Scotland, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Rawlik+K%22">Rawlik K</searchLink>; The Roslin Institute, University of Edinburgh, Easter Bush, Edinburgh, Scotland, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Boutin+TS%22">Boutin TS</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Zeng+Y%22">Zeng Y</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom.; Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.; Guangdong Province Translational Forensic Medicine Engineering Technology Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.; Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Amador+C%22">Amador C</searchLink>; 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MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hayward+C%22">Hayward C</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Wilson+JF%22">Wilson JF</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom.; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, Scotland, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tenesa+A%22">Tenesa A</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom.; 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