Safety, Pharmacokinetics, and Activity of High-Dose Ivermectin and Chloroquine against the Liver Stage of Plasmodium cynomolgi Infection in Rhesus Macaques.

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Title: Safety, Pharmacokinetics, and Activity of High-Dose Ivermectin and Chloroquine against the Liver Stage of Plasmodium cynomolgi Infection in Rhesus Macaques.
Authors: Vanachayangkul P; Department of Bacterial and Parasitic Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand., Im-Erbsin R; Department of Veterinary Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand., Tungtaeng A; Department of Veterinary Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand., Kodchakorn C; Department of Bacterial and Parasitic Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand., Roth A; Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.; Center for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, Florida, USA., Adams J; Center for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, Florida, USA., Chaisatit C; Department of Bacterial and Parasitic Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand., Saingam P; Department of Bacterial and Parasitic Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand., Sciotti RJ; Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA., Reichard GA; Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA., Nolan CK; Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA., Pybus BS; Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA., Black CC; Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA., Lugo-Roman LA; Department of Veterinary Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand., Wegner MD; Department of Veterinary Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand., Smith PL; Department of Bacterial and Parasitic Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand., Wojnarski M; Department of Bacterial and Parasitic Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand., Vesely BA; Department of Bacterial and Parasitic Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand., Kobylinski KC; Department of Entomology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand kobylinskikevin@yahoo.com.
Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2020 Aug 20; Vol. 64 (9). Date of Electronic Publication: 2020 Aug 20 (Print Publication: 2020).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Safety, Pharmacokinetics, and Activity of High-Dose Ivermectin and Chloroquine against the Liver Stage of Plasmodium cynomolgi Infection in Rhesus Macaques.
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  Data: <searchLink fieldCode="AU" term="%22Vanachayangkul+P%22">Vanachayangkul P</searchLink>; Department of Bacterial and Parasitic Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Im-Erbsin+R%22">Im-Erbsin R</searchLink>; Department of Veterinary Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Tungtaeng+A%22">Tungtaeng A</searchLink>; Department of Veterinary Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Kodchakorn+C%22">Kodchakorn C</searchLink>; Department of Bacterial and Parasitic Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Roth+A%22">Roth A</searchLink>; Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.; Center for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Adams+J%22">Adams J</searchLink>; Center for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Chaisatit+C%22">Chaisatit C</searchLink>; Department of Bacterial and Parasitic Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Saingam+P%22">Saingam P</searchLink>; Department of Bacterial and Parasitic Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Sciotti+RJ%22">Sciotti RJ</searchLink>; Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Reichard+GA%22">Reichard GA</searchLink>; Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Nolan+CK%22">Nolan CK</searchLink>; Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Pybus+BS%22">Pybus BS</searchLink>; Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Black+CC%22">Black CC</searchLink>; Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Lugo-Roman+LA%22">Lugo-Roman LA</searchLink>; Department of Veterinary Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Wegner+MD%22">Wegner MD</searchLink>; Department of Veterinary Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Smith+PL%22">Smith PL</searchLink>; Department of Bacterial and Parasitic Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Wojnarski+M%22">Wojnarski M</searchLink>; Department of Bacterial and Parasitic Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Vesely+BA%22">Vesely BA</searchLink>; Department of Bacterial and Parasitic Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Kobylinski+KC%22">Kobylinski KC</searchLink>; Department of Entomology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand kobylinskikevin@yahoo.com.
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  Data: <searchLink fieldCode="JN" term="%220315061%22">Antimicrobial agents and chemotherapy</searchLink> [Antimicrob Agents Chemother] 2020 Aug 20; Vol. 64 (9). <i>Date of Electronic Publication: </i>2020 Aug 20 (<i>Print Publication: </i>2020).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Microbiology%22">American Society for Microbiology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0315061 <i>Publication Model: </i>Electronic-Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1098-6596 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200664804%22">00664804 </searchLink><i>NLM ISO Abbreviation: </i>Antimicrob Agents Chemother <i>Subsets: </i>MEDLINE
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        Value: 10.1128/AAC.00741-20
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              Text: 2020 Aug 20
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