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FOXA1 Mutations Reveal Distinct Chromatin Profiles and Influence Therapeutic Response in Breast Cancer.

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Title: FOXA1 Mutations Reveal Distinct Chromatin Profiles and Influence Therapeutic Response in Breast Cancer.
Authors: Arruabarrena-Aristorena A; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Maag JLV; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Kittane S; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Cai Y; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Karthaus WR; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Ladewig E; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Park J; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Kannan S; Bioinformatics Institute (A(∗)STAR), 30 Biopolis Street, 07-01 Matrix, Singapore 138671, Singapore., Ferrando L; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Internal Medicine, University of Genoa, Genova, Italy., Cocco E; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Ho SY; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Tan DS; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Sallaku M; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Wu F; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Acevedo B; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Selenica P; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Ross DS; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Witkin M; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Sawyers CL; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Reis-Filho JS; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Verma CS; Bioinformatics Institute (A(∗)STAR), 30 Biopolis Street, 07-01 Matrix, Singapore 138671, Singapore; Department of Biological Sciences, National University of Singapore, 14 Science Drive, Singapore 117543, Singapore; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore., Jauch R; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Koche R; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Baselga J; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Research & Development Oncology, AstraZeneca Pharmaceuticals, Gaithersburg, MD 20878, USA., Razavi P; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Toska E; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: etoska1@jhmi.edu., Scaltriti M; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: scaltrim@mskcc.org.
Source: Cancer cell [Cancer Cell] 2020 Oct 12; Vol. 38 (4), pp. 534-550.e9. Date of Electronic Publication: 2020 Sep 03.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: FOXA1 Mutations Reveal Distinct Chromatin Profiles and Influence Therapeutic Response in Breast Cancer.
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  Data: <searchLink fieldCode="AU" term="%22Arruabarrena-Aristorena+A%22">Arruabarrena-Aristorena A</searchLink>; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Maag+JLV%22">Maag JLV</searchLink>; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Kittane+S%22">Kittane S</searchLink>; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Cai+Y%22">Cai Y</searchLink>; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Karthaus+WR%22">Karthaus WR</searchLink>; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Ladewig+E%22">Ladewig E</searchLink>; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Park+J%22">Park J</searchLink>; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Kannan+S%22">Kannan S</searchLink>; Bioinformatics Institute (A(∗)STAR), 30 Biopolis Street, 07-01 Matrix, Singapore 138671, Singapore.<br /><searchLink fieldCode="AU" term="%22Ferrando+L%22">Ferrando L</searchLink>; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Internal Medicine, University of Genoa, Genova, Italy.<br /><searchLink fieldCode="AU" term="%22Cocco+E%22">Cocco E</searchLink>; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Ho+SY%22">Ho SY</searchLink>; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Tan+DS%22">Tan DS</searchLink>; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Sallaku+M%22">Sallaku M</searchLink>; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Wu+F%22">Wu F</searchLink>; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Acevedo+B%22">Acevedo B</searchLink>; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Selenica+P%22">Selenica P</searchLink>; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Ross+DS%22">Ross DS</searchLink>; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Witkin+M%22">Witkin M</searchLink>; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Sawyers+CL%22">Sawyers CL</searchLink>; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Reis-Filho+JS%22">Reis-Filho JS</searchLink>; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Verma+CS%22">Verma CS</searchLink>; Bioinformatics Institute (A(∗)STAR), 30 Biopolis Street, 07-01 Matrix, Singapore 138671, Singapore; Department of Biological Sciences, National University of Singapore, 14 Science Drive, Singapore 117543, Singapore; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore.<br /><searchLink fieldCode="AU" term="%22Jauch+R%22">Jauch R</searchLink>; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Koche+R%22">Koche R</searchLink>; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Baselga+J%22">Baselga J</searchLink>; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Research & Development Oncology, AstraZeneca Pharmaceuticals, Gaithersburg, MD 20878, USA.<br /><searchLink fieldCode="AU" term="%22Razavi+P%22">Razavi P</searchLink>; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Toska+E%22">Toska E</searchLink>; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: etoska1@jhmi.edu.<br /><searchLink fieldCode="AU" term="%22Scaltriti+M%22">Scaltriti M</searchLink>; Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: scaltrim@mskcc.org.
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