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Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein.

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Title: Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein.
Authors: Toelzer C; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave., Bristol BS8 1TQ, UK., Gupta K; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave., Bristol BS8 1TQ, UK., Yadav SKN; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave., Bristol BS8 1TQ, UK., Borucu U; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave., Bristol BS8 1TQ, UK., Davidson AD; School of Cellular and Molecular Medicine, University of Bristol, University Walk, Bristol BS8 1TD, UK., Kavanagh Williamson M; School of Cellular and Molecular Medicine, University of Bristol, University Walk, Bristol BS8 1TD, UK., Shoemark DK; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave., Bristol BS8 1TQ, UK., Garzoni F; Imophoron Ltd., St. Philips Central, Albert Rd., St. Philips, Bristol BS2 0XJ, UK., Staufer O; Department for Cellular Biophysics, Max Planck Institute for Medical Research, Jahnstraße 29, 69120 Heidelberg, Germany.; Institute for Physical Chemistry, Department for Biophysical Chemistry, University of Heidelberg, Im Neuenheimer Feld 253, 69120 Heidelberg, Germany.; Max Planck School Matter to Life, Jahnstraße 29, D-69120 Heidelberg, Germany.; Max Planck Bristol Centre for Minimal Biology, Cantock's Close, Bristol BS8 1TS, UK., Milligan R; School of Cellular and Molecular Medicine, University of Bristol, University Walk, Bristol BS8 1TD, UK., Capin J; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave., Bristol BS8 1TQ, UK., Mulholland AJ; School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK., Spatz J; Department for Cellular Biophysics, Max Planck Institute for Medical Research, Jahnstraße 29, 69120 Heidelberg, Germany.; Institute for Physical Chemistry, Department for Biophysical Chemistry, University of Heidelberg, Im Neuenheimer Feld 253, 69120 Heidelberg, Germany.; Max Planck School Matter to Life, Jahnstraße 29, D-69120 Heidelberg, Germany.; Max Planck Bristol Centre for Minimal Biology, Cantock's Close, Bristol BS8 1TS, UK., Fitzgerald D; Geneva Biotech Sàrl, Avenue de la Roseraie 64, 1205, Geneva, Switzerland., Berger I; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK. cb14941@bristol.ac.uk imre.berger@bristol.ac.uk.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave., Bristol BS8 1TQ, UK.; Max Planck Bristol Centre for Minimal Biology, Cantock's Close, Bristol BS8 1TS, UK.; School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK., Schaffitzel C; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK. cb14941@bristol.ac.uk imre.berger@bristol.ac.uk.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave., Bristol BS8 1TQ, UK.
Source: Science (New York, N.Y.) [Science] 2020 Nov 06; Vol. 370 (6517), pp. 725-730. Date of Electronic Publication: 2020 Sep 21.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
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  Data: Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein.
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  Data: <searchLink fieldCode="AU" term="%22Toelzer+C%22">Toelzer C</searchLink>; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave., Bristol BS8 1TQ, UK.<br /><searchLink fieldCode="AU" term="%22Gupta+K%22">Gupta K</searchLink>; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave., Bristol BS8 1TQ, UK.<br /><searchLink fieldCode="AU" term="%22Yadav+SKN%22">Yadav SKN</searchLink>; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave., Bristol BS8 1TQ, UK.<br /><searchLink fieldCode="AU" term="%22Borucu+U%22">Borucu U</searchLink>; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave., Bristol BS8 1TQ, UK.<br /><searchLink fieldCode="AU" term="%22Davidson+AD%22">Davidson AD</searchLink>; School of Cellular and Molecular Medicine, University of Bristol, University Walk, Bristol BS8 1TD, UK.<br /><searchLink fieldCode="AU" term="%22Kavanagh+Williamson+M%22">Kavanagh Williamson M</searchLink>; School of Cellular and Molecular Medicine, University of Bristol, University Walk, Bristol BS8 1TD, UK.<br /><searchLink fieldCode="AU" term="%22Shoemark+DK%22">Shoemark DK</searchLink>; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave., Bristol BS8 1TQ, UK.<br /><searchLink fieldCode="AU" term="%22Garzoni+F%22">Garzoni F</searchLink>; Imophoron Ltd., St. Philips Central, Albert Rd., St. Philips, Bristol BS2 0XJ, UK.<br /><searchLink fieldCode="AU" term="%22Staufer+O%22">Staufer O</searchLink>; Department for Cellular Biophysics, Max Planck Institute for Medical Research, Jahnstraße 29, 69120 Heidelberg, Germany.; Institute for Physical Chemistry, Department for Biophysical Chemistry, University of Heidelberg, Im Neuenheimer Feld 253, 69120 Heidelberg, Germany.; Max Planck School Matter to Life, Jahnstraße 29, D-69120 Heidelberg, Germany.; Max Planck Bristol Centre for Minimal Biology, Cantock's Close, Bristol BS8 1TS, UK.<br /><searchLink fieldCode="AU" term="%22Milligan+R%22">Milligan R</searchLink>; School of Cellular and Molecular Medicine, University of Bristol, University Walk, Bristol BS8 1TD, UK.<br /><searchLink fieldCode="AU" term="%22Capin+J%22">Capin J</searchLink>; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave., Bristol BS8 1TQ, UK.<br /><searchLink fieldCode="AU" term="%22Mulholland+AJ%22">Mulholland AJ</searchLink>; School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.<br /><searchLink fieldCode="AU" term="%22Spatz+J%22">Spatz J</searchLink>; Department for Cellular Biophysics, Max Planck Institute for Medical Research, Jahnstraße 29, 69120 Heidelberg, Germany.; Institute for Physical Chemistry, Department for Biophysical Chemistry, University of Heidelberg, Im Neuenheimer Feld 253, 69120 Heidelberg, Germany.; Max Planck School Matter to Life, Jahnstraße 29, D-69120 Heidelberg, Germany.; Max Planck Bristol Centre for Minimal Biology, Cantock's Close, Bristol BS8 1TS, UK.<br /><searchLink fieldCode="AU" term="%22Fitzgerald+D%22">Fitzgerald D</searchLink>; Geneva Biotech Sàrl, Avenue de la Roseraie 64, 1205, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Berger+I%22">Berger I</searchLink>; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK. cb14941@bristol.ac.uk imre.berger@bristol.ac.uk.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave., Bristol BS8 1TQ, UK.; Max Planck Bristol Centre for Minimal Biology, Cantock's Close, Bristol BS8 1TS, UK.; School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.<br /><searchLink fieldCode="AU" term="%22Schaffitzel+C%22">Schaffitzel C</searchLink>; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK. cb14941@bristol.ac.uk imre.berger@bristol.ac.uk.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave., Bristol BS8 1TQ, UK.
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