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Adaptive Evolution in Producing Microtiter Cultivations Generates Genetically Stable Escherichia coli Production Hosts for Continuous Bioprocessing.

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Title: Adaptive Evolution in Producing Microtiter Cultivations Generates Genetically Stable Escherichia coli Production Hosts for Continuous Bioprocessing.
Authors: Schuller A; Christian Doppler Laboratory for Production of Next-Level Biopharmaceuticals in E. coli, Department of Biotechnology, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna, A-1190, Austria., Cserjan-Puschmann M; Christian Doppler Laboratory for Production of Next-Level Biopharmaceuticals in E. coli, Department of Biotechnology, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna, A-1190, Austria., Köppl C; Christian Doppler Laboratory for Production of Next-Level Biopharmaceuticals in E. coli, Department of Biotechnology, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna, A-1190, Austria., Grabherr R; Christian Doppler Laboratory for Production of Next-Level Biopharmaceuticals in E. coli, Department of Biotechnology, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna, A-1190, Austria., Wagenknecht M; Boehringer Ingelheim RCV GmbH & Co KG, Dr.-Boehringer-Gasse 5-11, Vienna, A-1120, Austria., Schiavinato M; Department of Biotechnology, Institute of Computational Biology, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna, A-1190, Austria., Dohm JC; Department of Biotechnology, Institute of Computational Biology, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna, A-1190, Austria., Himmelbauer H; Department of Biotechnology, Institute of Computational Biology, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna, A-1190, Austria., Striedner G; Christian Doppler Laboratory for Production of Next-Level Biopharmaceuticals in E. coli, Department of Biotechnology, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna, A-1190, Austria.
Source: Biotechnology journal [Biotechnol J] 2021 Mar; Vol. 16 (3), pp. e2000376. Date of Electronic Publication: 2020 Nov 09.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 101265833 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7314 (Electronic) Linking ISSN: 18606768 NLM ISO Abbreviation: Biotechnol J Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Schuller+A%22">Schuller A</searchLink>; Christian Doppler Laboratory for Production of Next-Level Biopharmaceuticals in E. coli, Department of Biotechnology, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna, A-1190, Austria.<br /><searchLink fieldCode="AU" term="%22Cserjan-Puschmann+M%22">Cserjan-Puschmann M</searchLink>; Christian Doppler Laboratory for Production of Next-Level Biopharmaceuticals in E. coli, Department of Biotechnology, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna, A-1190, Austria.<br /><searchLink fieldCode="AU" term="%22Köppl+C%22">Köppl C</searchLink>; Christian Doppler Laboratory for Production of Next-Level Biopharmaceuticals in E. coli, Department of Biotechnology, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna, A-1190, Austria.<br /><searchLink fieldCode="AU" term="%22Grabherr+R%22">Grabherr R</searchLink>; Christian Doppler Laboratory for Production of Next-Level Biopharmaceuticals in E. coli, Department of Biotechnology, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna, A-1190, Austria.<br /><searchLink fieldCode="AU" term="%22Wagenknecht+M%22">Wagenknecht M</searchLink>; Boehringer Ingelheim RCV GmbH & Co KG, Dr.-Boehringer-Gasse 5-11, Vienna, A-1120, Austria.<br /><searchLink fieldCode="AU" term="%22Schiavinato+M%22">Schiavinato M</searchLink>; Department of Biotechnology, Institute of Computational Biology, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna, A-1190, Austria.<br /><searchLink fieldCode="AU" term="%22Dohm+JC%22">Dohm JC</searchLink>; Department of Biotechnology, Institute of Computational Biology, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna, A-1190, Austria.<br /><searchLink fieldCode="AU" term="%22Himmelbauer+H%22">Himmelbauer H</searchLink>; Department of Biotechnology, Institute of Computational Biology, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna, A-1190, Austria.<br /><searchLink fieldCode="AU" term="%22Striedner+G%22">Striedner G</searchLink>; Christian Doppler Laboratory for Production of Next-Level Biopharmaceuticals in E. coli, Department of Biotechnology, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna, A-1190, Austria.
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  Data: <searchLink fieldCode="JN" term="%22101265833%22">Biotechnology journal</searchLink> [Biotechnol J] 2021 Mar; Vol. 16 (3), pp. e2000376. <i>Date of Electronic Publication: </i>2020 Nov 09.
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