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Nonclinical Safety Assessment of FHTR2163, An Antigen-Binding Fragment Against HTRA1 for the Treatment of Geographic Atrophy.

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Title: Nonclinical Safety Assessment of FHTR2163, An Antigen-Binding Fragment Against HTRA1 for the Treatment of Geographic Atrophy.
Authors: Dere E; Department of Safety Assessment, 7412Genentech Inc., South San Francisco, CA, USA., Crowell S; Department of Preclinical and Translational Pharmacokinetics and Pharmacodynamics, 7412Genentech Inc., South San Francisco, CA, USA., Maia M; Department of Bioanalytical Sciences, 7412Genentech Inc., South San Francisco, CA, USA., Schuetz C; Department of Safety Assessment, 7412Genentech Inc., South San Francisco, CA, USA., Lai P; Department of Early Clinical Development OMNI, 7412Genentech Inc., South San Francisco, CA, USA., Bantseev V; Department of Safety Assessment, 7412Genentech Inc., South San Francisco, CA, USA., Booler H; Department of Safety Assessment, 7412Genentech Inc., South San Francisco, CA, USA.; Department of BIOmics and Pathology, F. Hoffmann-La Roche, Ltd., Basel, Switzerland.
Source: Toxicologic pathology [Toxicol Pathol] 2021 Apr; Vol. 49 (3), pp. 610-620. Date of Electronic Publication: 2020 Dec 10.
Publication Type: Journal Article
Journal Info: Publisher: Sage Publications Country of Publication: United States NLM ID: 7905907 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-1601 (Electronic) Linking ISSN: 01926233 NLM ISO Abbreviation: Toxicol Pathol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Dere+E%22">Dere E</searchLink>; Department of Safety Assessment, 7412Genentech Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Crowell+S%22">Crowell S</searchLink>; Department of Preclinical and Translational Pharmacokinetics and Pharmacodynamics, 7412Genentech Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Maia+M%22">Maia M</searchLink>; Department of Bioanalytical Sciences, 7412Genentech Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Schuetz+C%22">Schuetz C</searchLink>; Department of Safety Assessment, 7412Genentech Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lai+P%22">Lai P</searchLink>; Department of Early Clinical Development OMNI, 7412Genentech Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bantseev+V%22">Bantseev V</searchLink>; Department of Safety Assessment, 7412Genentech Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Booler+H%22">Booler H</searchLink>; Department of Safety Assessment, 7412Genentech Inc., South San Francisco, CA, USA.; Department of BIOmics and Pathology, F. Hoffmann-La Roche, Ltd., Basel, Switzerland.
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  Data: <searchLink fieldCode="JN" term="%227905907%22">Toxicologic pathology</searchLink> [Toxicol Pathol] 2021 Apr; Vol. 49 (3), pp. 610-620. <i>Date of Electronic Publication: </i>2020 Dec 10.
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              Text: 2021 Apr
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