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The Parkinson's disease-associated gene ITPKB protects against α-synuclein aggregation by regulating ER-to-mitochondria calcium release.

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Title: The Parkinson's disease-associated gene ITPKB protects against α-synuclein aggregation by regulating ER-to-mitochondria calcium release.
Authors: Apicco DJ; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142; dan.apicco@gmail.com warren.hirst@biogen.com.; Biogen Postdoctoral Scientist Program, Biogen, Cambridge, MA 02142., Shlevkov E; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142., Nezich CL; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142., Tran DT; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142., Guilmette E; Gene Therapy Accelerator Unit, Biotherapeutics and Medicinal Sciences, Biogen, Cambridge, MA 02142., Nicholatos JW; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142.; Biogen Postdoctoral Scientist Program, Biogen, Cambridge, MA 02142., Bantle CM; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142.; Biogen Postdoctoral Scientist Program, Biogen, Cambridge, MA 02142., Chen Y; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142., Glajch KE; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142., Abraham NA; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142., Dang LT; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142., Kaynor GC; Multiple Sclerosis and Neurorepair Research Unit, Biogen, Cambridge, MA 02142., Tsai EA; Human Genetics, Translational Biology, Biogen, Cambridge, MA 02142., Nguyen KH; Human Genetics, Translational Biology, Biogen, Cambridge, MA 02142., Groot J; Genome Technologies and Scientific Computing, Translational Biology, Biogen, Cambridge, MA 02142., Liu Y; Biologics Drug Discovery, Biotherapeutics and Medicinal Sciences, Biogen, Cambridge, MA 02142., Weihofen A; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142., Hurt JA; Human Target Validation Core, Translational Biology, Biogen, Cambridge, MA 02142., Runz H; Human Genetics, Translational Biology, Biogen, Cambridge, MA 02142., Hirst WD; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142; dan.apicco@gmail.com warren.hirst@biogen.com.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Jan 05; Vol. 118 (1).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: The Parkinson's disease-associated gene ITPKB protects against α-synuclein aggregation by regulating ER-to-mitochondria calcium release.
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  Data: <searchLink fieldCode="AU" term="%22Apicco+DJ%22">Apicco DJ</searchLink>; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142; dan.apicco@gmail.com warren.hirst@biogen.com.; Biogen Postdoctoral Scientist Program, Biogen, Cambridge, MA 02142.<br /><searchLink fieldCode="AU" term="%22Shlevkov+E%22">Shlevkov E</searchLink>; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142.<br /><searchLink fieldCode="AU" term="%22Nezich+CL%22">Nezich CL</searchLink>; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142.<br /><searchLink fieldCode="AU" term="%22Tran+DT%22">Tran DT</searchLink>; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142.<br /><searchLink fieldCode="AU" term="%22Guilmette+E%22">Guilmette E</searchLink>; Gene Therapy Accelerator Unit, Biotherapeutics and Medicinal Sciences, Biogen, Cambridge, MA 02142.<br /><searchLink fieldCode="AU" term="%22Nicholatos+JW%22">Nicholatos JW</searchLink>; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142.; Biogen Postdoctoral Scientist Program, Biogen, Cambridge, MA 02142.<br /><searchLink fieldCode="AU" term="%22Bantle+CM%22">Bantle CM</searchLink>; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142.; Biogen Postdoctoral Scientist Program, Biogen, Cambridge, MA 02142.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142.<br /><searchLink fieldCode="AU" term="%22Glajch+KE%22">Glajch KE</searchLink>; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142.<br /><searchLink fieldCode="AU" term="%22Abraham+NA%22">Abraham NA</searchLink>; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142.<br /><searchLink fieldCode="AU" term="%22Dang+LT%22">Dang LT</searchLink>; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142.<br /><searchLink fieldCode="AU" term="%22Kaynor+GC%22">Kaynor GC</searchLink>; Multiple Sclerosis and Neurorepair Research Unit, Biogen, Cambridge, MA 02142.<br /><searchLink fieldCode="AU" term="%22Tsai+EA%22">Tsai EA</searchLink>; Human Genetics, Translational Biology, Biogen, Cambridge, MA 02142.<br /><searchLink fieldCode="AU" term="%22Nguyen+KH%22">Nguyen KH</searchLink>; Human Genetics, Translational Biology, Biogen, Cambridge, MA 02142.<br /><searchLink fieldCode="AU" term="%22Groot+J%22">Groot J</searchLink>; Genome Technologies and Scientific Computing, Translational Biology, Biogen, Cambridge, MA 02142.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Biologics Drug Discovery, Biotherapeutics and Medicinal Sciences, Biogen, Cambridge, MA 02142.<br /><searchLink fieldCode="AU" term="%22Weihofen+A%22">Weihofen A</searchLink>; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142.<br /><searchLink fieldCode="AU" term="%22Hurt+JA%22">Hurt JA</searchLink>; Human Target Validation Core, Translational Biology, Biogen, Cambridge, MA 02142.<br /><searchLink fieldCode="AU" term="%22Runz+H%22">Runz H</searchLink>; Human Genetics, Translational Biology, Biogen, Cambridge, MA 02142.<br /><searchLink fieldCode="AU" term="%22Hirst+WD%22">Hirst WD</searchLink>; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142; dan.apicco@gmail.com warren.hirst@biogen.com.
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