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Afatinib Exerts Immunomodulatory Effects by Targeting the Pyrimidine Biosynthesis Enzyme CAD.

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Title: Afatinib Exerts Immunomodulatory Effects by Targeting the Pyrimidine Biosynthesis Enzyme CAD.
Authors: Tu HF; Department of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan., Ko CJ; Department of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.; Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, Texas., Lee CT; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Lee CF; Department of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan., Lan SW; Department of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan., Lin HH; Department of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan., Lin HY; Department of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan., Ku CC; Graduate Institute of Immunology, National Taiwan University College of Medicine, Taipei, Taiwan., Lee DY; Graduate Institute of Integrated Medicine/Department of Medical Research, China Medical University Hospital, Taichung, Taiwan., Chen IC; Department of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan., Chuang YH; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan., Del Caño-Ochoa F; Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain.; Group 739, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER)-Instituto de Salud Carlos III, Valencia, Spain., Ramón-Maiques S; Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain.; Group 739, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER)-Instituto de Salud Carlos III, Valencia, Spain., Ho CC; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. mslee2006@ntu.edu.tw ccho1203@ntu.edu.tw., Lee MS; Department of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan. mslee2006@ntu.edu.tw ccho1203@ntu.edu.tw., Chang GD; Graduate Institute of Biochemical Sciences, College of Life Science, National Taiwan University, Taipei, Taiwan.
Source: Cancer research [Cancer Res] 2021 Jun 15; Vol. 81 (12), pp. 3270-3282. Date of Electronic Publication: 2021 Mar 26.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Afatinib Exerts Immunomodulatory Effects by Targeting the Pyrimidine Biosynthesis Enzyme CAD.
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  Data: <searchLink fieldCode="AU" term="%22Tu+HF%22">Tu HF</searchLink>; Department of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ko+CJ%22">Ko CJ</searchLink>; Department of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.; Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Lee+CT%22">Lee CT</searchLink>; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+CF%22">Lee CF</searchLink>; Department of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lan+SW%22">Lan SW</searchLink>; Department of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+HH%22">Lin HH</searchLink>; Department of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+HY%22">Lin HY</searchLink>; Department of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ku+CC%22">Ku CC</searchLink>; Graduate Institute of Immunology, National Taiwan University College of Medicine, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+DY%22">Lee DY</searchLink>; Graduate Institute of Integrated Medicine/Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+IC%22">Chen IC</searchLink>; Department of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chuang+YH%22">Chuang YH</searchLink>; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Del+Caño-Ochoa+F%22">Del Caño-Ochoa F</searchLink>; Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain.; Group 739, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER)-Instituto de Salud Carlos III, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Ramón-Maiques+S%22">Ramón-Maiques S</searchLink>; Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain.; Group 739, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER)-Instituto de Salud Carlos III, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Ho+CC%22">Ho CC</searchLink>; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. mslee2006@ntu.edu.tw ccho1203@ntu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Lee+MS%22">Lee MS</searchLink>; Department of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan. mslee2006@ntu.edu.tw ccho1203@ntu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Chang+GD%22">Chang GD</searchLink>; Graduate Institute of Biochemical Sciences, College of Life Science, National Taiwan University, Taipei, Taiwan.
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  Data: <searchLink fieldCode="JN" term="%222984705R%22">Cancer research</searchLink> [Cancer Res] 2021 Jun 15; Vol. 81 (12), pp. 3270-3282. <i>Date of Electronic Publication: </i>2021 Mar 26.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2984705R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1538-7445 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200085472%22">00085472 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Res <i>Subsets: </i>MEDLINE
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        Value: 10.1158/0008-5472.CAN-20-3436
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              Text: 2021 Jun 15
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