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Clofibrate, a Peroxisome Proliferator-Activated Receptor-Alpha (PPARα) Agonist, and Its Molecular Mechanisms of Action against Sodium Fluoride-Induced Toxicity.

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Title: Clofibrate, a Peroxisome Proliferator-Activated Receptor-Alpha (PPARα) Agonist, and Its Molecular Mechanisms of Action against Sodium Fluoride-Induced Toxicity.
Authors: Oyagbemi AA; Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria. ademola.oyagbemi778@gmail.com., Adejumobi OA; Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria., Jarikre TA; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria., Ajani OS; Department of Theriogenology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria., Asenuga ER; Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Benin, Benin, Nigeria., Gbadamosi IT; Department of Botany, Faculty of Science, University of Ibadan, Ibadan, Nigeria., Adedapo ADA; Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan, Nigeria., Aro AO; Department of Agriculture and Animal Health, College of Agriculture and Environmental Sciences, University of South Africa, Florida, South Africa., Ogunpolu BS; Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria., Hassan FO; Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria., Falayi OO; Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria., Ogunmiluyi IO; Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria., Omobowale TO; Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria., Arojojoye OA; Department of Biochemistry, Faculty of Sciences, Lead City University, Ibadan, Nigeria., Ola-Davies OE; Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria., Saba AB; Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria., Adedapo AA; Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria., Emikpe BO; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria., Oyeyemi MO; Department of Theriogenology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria., Nkadimeng SM; Phytomedicine Programme, Department of Paraclinical Science, Faculty of Veterinary Science, University of Pretoria, Old Soutpan Road, Onderstepoort, Pretoria, 0110, South Africa., McGaw LJ; Phytomedicine Programme, Department of Paraclinical Science, Faculty of Veterinary Science, University of Pretoria, Old Soutpan Road, Onderstepoort, Pretoria, 0110, South Africa., Kayoka-Kabongo PN; Department of Agriculture and Animal Health, College of Agriculture and Environmental Sciences, University of South Africa, Florida, South Africa., Oguntibeju OO; Phytomedicine and Phytochemistry Group, Oxidative Stress Research Centre, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville, Cape Town, 7535, South Africa., Yakubu MA; Department of Environmental & Interdisciplinary Sciences, College of Science, Engineering & Technology, Vascular Biology Unit, Center for Cardiovascular Diseases, Texas Southern University, Houston, TX, USA.
Source: Biological trace element research [Biol Trace Elem Res] 2022 Mar; Vol. 200 (3), pp. 1220-1236. Date of Electronic Publication: 2021 Apr 24.
Publication Type: Journal Article
Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 7911509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0720 (Electronic) Linking ISSN: 01634984 NLM ISO Abbreviation: Biol Trace Elem Res Subsets: MEDLINE
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  Data: Clofibrate, a Peroxisome Proliferator-Activated Receptor-Alpha (PPARα) Agonist, and Its Molecular Mechanisms of Action against Sodium Fluoride-Induced Toxicity.
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Department of Botany, Faculty of Science, University of Ibadan, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Adedapo+ADA%22">Adedapo ADA</searchLink>; Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Aro+AO%22">Aro AO</searchLink>; Department of Agriculture and Animal Health, College of Agriculture and Environmental Sciences, University of South Africa, Florida, South Africa.<br /><searchLink fieldCode="AU" term="%22Ogunpolu+BS%22">Ogunpolu BS</searchLink>; Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Hassan+FO%22">Hassan FO</searchLink>; Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Falayi+OO%22">Falayi OO</searchLink>; Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Ogunmiluyi+IO%22">Ogunmiluyi IO</searchLink>; Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Omobowale+TO%22">Omobowale TO</searchLink>; Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Arojojoye+OA%22">Arojojoye OA</searchLink>; Department of Biochemistry, Faculty of Sciences, Lead City University, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Ola-Davies+OE%22">Ola-Davies OE</searchLink>; Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Saba+AB%22">Saba AB</searchLink>; Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Adedapo+AA%22">Adedapo AA</searchLink>; Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Emikpe+BO%22">Emikpe BO</searchLink>; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Oyeyemi+MO%22">Oyeyemi MO</searchLink>; Department of Theriogenology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Nkadimeng+SM%22">Nkadimeng SM</searchLink>; Phytomedicine Programme, Department of Paraclinical Science, Faculty of Veterinary Science, University of Pretoria, Old Soutpan Road, Onderstepoort, Pretoria, 0110, South Africa.<br /><searchLink fieldCode="AU" term="%22McGaw+LJ%22">McGaw LJ</searchLink>; Phytomedicine Programme, Department of Paraclinical Science, Faculty of Veterinary Science, University of Pretoria, Old Soutpan Road, Onderstepoort, Pretoria, 0110, South Africa.<br /><searchLink fieldCode="AU" term="%22Kayoka-Kabongo+PN%22">Kayoka-Kabongo PN</searchLink>; Department of Agriculture and Animal Health, College of Agriculture and Environmental Sciences, University of South Africa, Florida, South Africa.<br /><searchLink fieldCode="AU" term="%22Oguntibeju+OO%22">Oguntibeju OO</searchLink>; Phytomedicine and Phytochemistry Group, Oxidative Stress Research Centre, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville, Cape Town, 7535, South Africa.<br /><searchLink fieldCode="AU" term="%22Yakubu+MA%22">Yakubu MA</searchLink>; Department of Environmental & Interdisciplinary Sciences, College of Science, Engineering & Technology, Vascular Biology Unit, Center for Cardiovascular Diseases, Texas Southern University, Houston, TX, USA.
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