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Efficacy of a low-dose candidate malaria vaccine, R21 in adjuvant Matrix-M, with seasonal administration to children in Burkina Faso: a randomised controlled trial.

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Title: Efficacy of a low-dose candidate malaria vaccine, R21 in adjuvant Matrix-M, with seasonal administration to children in Burkina Faso: a randomised controlled trial.
Authors: Datoo MS; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Natama MH; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Somé A; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Traoré O; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Rouamba T; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Bellamy D; The Jenner Institute Laboratories, University of Oxford, UK., Yameogo P; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Valia D; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Tegneri M; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Ouedraogo F; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Soma R; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Sawadogo S; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Sorgho F; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Derra K; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Rouamba E; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Orindi B; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Ramos Lopez F; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Flaxman A; The Jenner Institute Laboratories, University of Oxford, UK., Cappuccini F; The Jenner Institute Laboratories, University of Oxford, UK., Kailath R; The Jenner Institute Laboratories, University of Oxford, UK., Elias S; The Jenner Institute Laboratories, University of Oxford, UK., Mukhopadhyay E; The Jenner Institute Laboratories, University of Oxford, UK., Noe A; The Jenner Institute Laboratories, University of Oxford, UK., Cairns M; London School of Hygiene & Tropical Medicine, London, UK., Lawrie A; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Roberts R; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Valéa I; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Sorgho H; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Williams N; Department of Primary Care, University of Oxford, UK., Glenn G; Novavax, Gaithersburg, MD, USA., Fries L; Novavax, Gaithersburg, MD, USA., Reimer J; Novavax, Uppsala, Sweden., Ewer KJ; The Jenner Institute Laboratories, University of Oxford, UK., Shaligram U; Serum Institute of India, Pune, India., Hill AVS; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK; The Jenner Institute Laboratories, University of Oxford, UK. Electronic address: adrian.hill@ndm.ox.ac.uk., Tinto H; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso. Electronic address: tintoh@crun.bf.
Source: Lancet (London, England) [Lancet] 2021 May 15; Vol. 397 (10287), pp. 1809-1818. Date of Electronic Publication: 2021 May 05.
Publication Type: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Efficacy of a low-dose candidate malaria vaccine, R21 in adjuvant Matrix-M, with seasonal administration to children in Burkina Faso: a randomised controlled trial.
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  Data: <searchLink fieldCode="AU" term="%22Datoo+MS%22">Datoo MS</searchLink>; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Natama+MH%22">Natama MH</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Somé+A%22">Somé A</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Traoré+O%22">Traoré O</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Rouamba+T%22">Rouamba T</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Bellamy+D%22">Bellamy D</searchLink>; The Jenner Institute Laboratories, University of Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Yameogo+P%22">Yameogo P</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Valia+D%22">Valia D</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Tegneri+M%22">Tegneri M</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Ouedraogo+F%22">Ouedraogo F</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Soma+R%22">Soma R</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Sawadogo+S%22">Sawadogo S</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Sorgho+F%22">Sorgho F</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Derra+K%22">Derra K</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Rouamba+E%22">Rouamba E</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Orindi+B%22">Orindi B</searchLink>; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Ramos+Lopez+F%22">Ramos Lopez F</searchLink>; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Flaxman+A%22">Flaxman A</searchLink>; The Jenner Institute Laboratories, University of Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Cappuccini+F%22">Cappuccini F</searchLink>; The Jenner Institute Laboratories, University of Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Kailath+R%22">Kailath R</searchLink>; The Jenner Institute Laboratories, University of Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Elias+S%22">Elias S</searchLink>; The Jenner Institute Laboratories, University of Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Mukhopadhyay+E%22">Mukhopadhyay E</searchLink>; The Jenner Institute Laboratories, University of Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Noe+A%22">Noe A</searchLink>; The Jenner Institute Laboratories, University of Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Cairns+M%22">Cairns M</searchLink>; London School of Hygiene & Tropical Medicine, London, UK.<br /><searchLink fieldCode="AU" term="%22Lawrie+A%22">Lawrie A</searchLink>; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Roberts+R%22">Roberts R</searchLink>; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Valéa+I%22">Valéa I</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Sorgho+H%22">Sorgho H</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Williams+N%22">Williams N</searchLink>; Department of Primary Care, University of Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Glenn+G%22">Glenn G</searchLink>; Novavax, Gaithersburg, MD, USA.<br /><searchLink fieldCode="AU" term="%22Fries+L%22">Fries L</searchLink>; Novavax, Gaithersburg, MD, USA.<br /><searchLink fieldCode="AU" term="%22Reimer+J%22">Reimer J</searchLink>; Novavax, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Ewer+KJ%22">Ewer KJ</searchLink>; The Jenner Institute Laboratories, University of Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Shaligram+U%22">Shaligram U</searchLink>; Serum Institute of India, Pune, India.<br /><searchLink fieldCode="AU" term="%22Hill+AVS%22">Hill AVS</searchLink>; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK; The Jenner Institute Laboratories, University of Oxford, UK. Electronic address: adrian.hill@ndm.ox.ac.uk.<br /><searchLink fieldCode="AU" term="%22Tinto+H%22">Tinto H</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso. Electronic address: tintoh@crun.bf.
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