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DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function.

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Title: DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function.
Authors: Matías-García PR; TUM School of Medicine, Technical University of Munich, Munich, Germany. pamela.matias@helmholtz-muenchen.de.; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich/Neuherberg, Germany. pamela.matias@helmholtz-muenchen.de.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich/Neuherberg, Germany. pamela.matias@helmholtz-muenchen.de.; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany. pamela.matias@helmholtz-muenchen.de., Ward-Caviness CK; Center for Public Health and Environmental Assessment, US Environmental Protection Agency, Chapel Hill, NC, USA., Raffield LM; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Gao X; Laboratory of Precision Environmental Health, Mailman School of Public Health, Columbia University, New York, NY, USA., Zhang Y; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Wilson R; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich/Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich/Neuherberg, Germany., Gào X; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Nano J; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich/Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Bostom A; Center For Primary Care and Prevention, Memorial Hospital of Rhode Island, Pawtucket, RI, USA., Colicino E; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Correa A; Departments of Medicine and Pediatrics, University of Mississippi Medical Center, Jackson, MS, USA., Coull B; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Eaton C; Center For Primary Care and Prevention, Memorial Hospital of Rhode Island, Pawtucket, RI, USA.; Department of Family Medicine, Warren Alpert Medical School, Brown University, Providence, RI, USA., Hou L; Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Just AC; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kunze S; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich/Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich/Neuherberg, Germany., Lange L; Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA., Lange E; Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA., Lin X; Veterans Affairs Normative Aging Study, Veterans Affairs Boston Healthcare System, Department of Medicine, Boston University School of Medicine, Boston, MA, USA., Liu S; Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA., Nwanaji-Enwerem JC; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Reiner A; Department of Epidemiology, University of Washington, Seattle, WA, USA., Shen J; Department of Population Health Sciences, School of Medicine, University of Utah, Salt Lake City, UT, USA., Schöttker B; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Network Aging Research, University of Heidelberg, Heidelberg, Germany., Vokonas P; Veterans Affairs Normative Aging Study, Veterans Affairs Boston Healthcare System, Department of Medicine, Boston University School of Medicine, Boston, MA, USA., Zheng Y; Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Young B; Nephrology, Hospital and Specialty Medicine and Center for Innovation for Veteran-Centered and Value Driven Care, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA.; Division of Nephrology, Kidney Research Institute, University of Washington, Seattle, WA, USA., Schwartz J; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Horvath S; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Lu A; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Whitsel EA; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.; Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC, USA., Koenig W; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.; Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany., Adamski J; Research Unit Molecular Endocrinology and Metabolism, Genome Analysis Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich/Neuherberg, Germany.; Chair for Experimental Genetics, Technical University of Munich, Freising-Weihenstephan, Germany.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Winkelmann J; Institute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich/Neuherberg, Germany.; Chair Neurogenetics, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; Institute of Human Genetics, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Network Aging Research, University of Heidelberg, Heidelberg, Germany., Baccarelli AA; Laboratory of Precision Environmental Health, Mailman School of Public Health, Columbia University, New York, NY, USA., Gieger C; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich/Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich/Neuherberg, Germany., Peters A; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich/Neuherberg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Franceschini N; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Waldenberger M; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich/Neuherberg, Germany. waldenberger@helmholtz-muenchen.de.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich/Neuherberg, Germany. waldenberger@helmholtz-muenchen.de.; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany. waldenberger@helmholtz-muenchen.de.
Source: Clinical epigenetics [Clin Epigenetics] 2021 Jun 02; Vol. 13 (1), pp. 121. Date of Electronic Publication: 2021 Jun 02.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Biomed Central Country of Publication: Germany NLM ID: 101516977 Publication Model: Electronic Cited Medium: Internet ISSN: 1868-7083 (Electronic) Linking ISSN: 18687075 NLM ISO Abbreviation: Clin Epigenetics Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function.
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