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Dnmt1 has de novo activity targeted to transposable elements.

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Title: Dnmt1 has de novo activity targeted to transposable elements.
Authors: Haggerty C; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany., Kretzmer H; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany., Riemenschneider C; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.; Institute of Biotechnology, Technische Universität Berlin, Berlin, Germany., Kumar AS; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany., Mattei AL; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA., Bailly N; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany., Gottfreund J; Department of Genetics and Epigenetics, Saarland University, Saarbrücken, Germany., Giesselmann P; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany., Weigert R; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.; Institute of Biotechnology, Technische Universität Berlin, Berlin, Germany., Brändl B; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.; Christian-Albrechts-Universität zu Kiel, Department of Psychiatry and Psychotherapy, Kiel, Germany., Giehr P; Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland., Buschow R; Microscopy and Cryo-electron Microscopy Service Group, Max Planck Institute for Molecular Genetics, Berlin, Germany., Galonska C; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.; Spatial Transcriptomics, Part of 10x Genomics Inc, Stockholm, Sweden., von Meyenn F; Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland., Pappalardi MB; Epigenetics Research Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., McCabe MT; Epigenetics Research Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Wittler L; Department of Developmental Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany., Giesecke-Thiel C; Flow Cytometry Joint Facilities Scientific Service, Max Planck Institute for Molecular Genetics, Berlin, Germany., Mielke T; Microscopy and Cryo-electron Microscopy Service Group, Max Planck Institute for Molecular Genetics, Berlin, Germany., Meierhofer D; Mass Spectrometry Joint Facilities Scientific Service, Max Planck Institute for Molecular Genetics, Berlin, Germany., Timmermann B; Sequencing Core Facility, Max Planck Institute for Molecular Genetics, Berlin, Germany., Müller FJ; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.; Christian-Albrechts-Universität zu Kiel, Department of Psychiatry and Psychotherapy, Kiel, Germany., Walter J; Department of Genetics and Epigenetics, Saarland University, Saarbrücken, Germany., Meissner A; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany. meissner@molgen.mpg.de.; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany. meissner@molgen.mpg.de.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. meissner@molgen.mpg.de.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. meissner@molgen.mpg.de.
Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2021 Jul; Vol. 28 (7), pp. 594-603. Date of Electronic Publication: 2021 Jun 17.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE
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  Data: Dnmt1 has de novo activity targeted to transposable elements.
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  Data: <searchLink fieldCode="AU" term="%22Haggerty+C%22">Haggerty C</searchLink>; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Kretzmer+H%22">Kretzmer H</searchLink>; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Riemenschneider+C%22">Riemenschneider C</searchLink>; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.; Institute of Biotechnology, Technische Universität Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Kumar+AS%22">Kumar AS</searchLink>; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Mattei+AL%22">Mattei AL</searchLink>; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bailly+N%22">Bailly N</searchLink>; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Gottfreund+J%22">Gottfreund J</searchLink>; Department of Genetics and Epigenetics, Saarland University, Saarbrücken, Germany.<br /><searchLink fieldCode="AU" term="%22Giesselmann+P%22">Giesselmann P</searchLink>; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Weigert+R%22">Weigert R</searchLink>; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.; Institute of Biotechnology, Technische Universität Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Brändl+B%22">Brändl B</searchLink>; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.; Christian-Albrechts-Universität zu Kiel, Department of Psychiatry and Psychotherapy, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Giehr+P%22">Giehr P</searchLink>; Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland.<br /><searchLink fieldCode="AU" term="%22Buschow+R%22">Buschow R</searchLink>; Microscopy and Cryo-electron Microscopy Service Group, Max Planck Institute for Molecular Genetics, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Galonska+C%22">Galonska C</searchLink>; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.; Spatial Transcriptomics, Part of 10x Genomics Inc, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22von+Meyenn+F%22">von Meyenn F</searchLink>; Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland.<br /><searchLink fieldCode="AU" term="%22Pappalardi+MB%22">Pappalardi MB</searchLink>; Epigenetics Research Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA.<br /><searchLink fieldCode="AU" term="%22McCabe+MT%22">McCabe MT</searchLink>; Epigenetics Research Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wittler+L%22">Wittler L</searchLink>; Department of Developmental Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Giesecke-Thiel+C%22">Giesecke-Thiel C</searchLink>; Flow Cytometry Joint Facilities Scientific Service, Max Planck Institute for Molecular Genetics, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Mielke+T%22">Mielke T</searchLink>; Microscopy and Cryo-electron Microscopy Service Group, Max Planck Institute for Molecular Genetics, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Meierhofer+D%22">Meierhofer D</searchLink>; Mass Spectrometry Joint Facilities Scientific Service, Max Planck Institute for Molecular Genetics, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Timmermann+B%22">Timmermann B</searchLink>; Sequencing Core Facility, Max Planck Institute for Molecular Genetics, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Müller+FJ%22">Müller FJ</searchLink>; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.; Christian-Albrechts-Universität zu Kiel, Department of Psychiatry and Psychotherapy, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Walter+J%22">Walter J</searchLink>; Department of Genetics and Epigenetics, Saarland University, Saarbrücken, Germany.<br /><searchLink fieldCode="AU" term="%22Meissner+A%22">Meissner A</searchLink>; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany. meissner@molgen.mpg.de.; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany. meissner@molgen.mpg.de.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. meissner@molgen.mpg.de.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. meissner@molgen.mpg.de.
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