The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes. - Ortmann BM; Burrows N; Lobb IT; Arnaiz E; Wit N; Bailey PSJ; Jordon LH; Lombardi O; Peñalver A; McCaffrey J; Seear R; Mole DR; et al. (Nature genetics, 2021)