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Safety, pharmacokinetics and quantitative EEG modulation of TAK-071, a novel muscarinic M1 receptor positive allosteric modulator, in healthy subjects.

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Title: Safety, pharmacokinetics and quantitative EEG modulation of TAK-071, a novel muscarinic M1 receptor positive allosteric modulator, in healthy subjects.
Authors: Yin W; Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA., Mamashli F; Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA.; Signal Insights, LLC, Cambridge, MA, USA., Buhl DL; Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA., Khudyakov P; Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA., Volfson D; Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA., Martenyi F; Prothena Biosciences, South San Francisco, CA, USA., Gevorkyan H; California Clinical Trials Medical Group, in affiliation with Parexel International, Glendale, CA, USA., Rosen L; Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA., Simen AA; Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA.
Source: British journal of clinical pharmacology [Br J Clin Pharmacol] 2022 Feb; Vol. 88 (2), pp. 600-612. Date of Electronic Publication: 2021 Jul 31.
Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7503323 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2125 (Electronic) Linking ISSN: 03065251 NLM ISO Abbreviation: Br J Clin Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Safety, pharmacokinetics and quantitative EEG modulation of TAK-071, a novel muscarinic M1 receptor positive allosteric modulator, in healthy subjects.
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  Data: <searchLink fieldCode="AU" term="%22Yin+W%22">Yin W</searchLink>; Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mamashli+F%22">Mamashli F</searchLink>; Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA.; Signal Insights, LLC, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Buhl+DL%22">Buhl DL</searchLink>; Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Khudyakov+P%22">Khudyakov P</searchLink>; Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Volfson+D%22">Volfson D</searchLink>; Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Martenyi+F%22">Martenyi F</searchLink>; Prothena Biosciences, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gevorkyan+H%22">Gevorkyan H</searchLink>; California Clinical Trials Medical Group, in affiliation with Parexel International, Glendale, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rosen+L%22">Rosen L</searchLink>; Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Simen+AA%22">Simen AA</searchLink>; Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA.
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  Data: <searchLink fieldCode="JN" term="%227503323%22">British journal of clinical pharmacology</searchLink> [Br J Clin Pharmacol] 2022 Feb; Vol. 88 (2), pp. 600-612. <i>Date of Electronic Publication: </i>2021 Jul 31.
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        Value: 10.1111/bcp.14975
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              Text: 2022 Feb
              Type: published
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