Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors.
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| Title: | Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors. |
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| Authors: | Lucas SCC, Atkinson SJ, Chung CW, Davis R, Gordon L, Grandi P; IVIVT Cellzome, Platform Technology and Science, GlaxoSmithKline, Meyerhofstrasse 1, 69117 Heidelberg, Germany., Gray JJR, Grimes T, Phillipou A, Preston AG, Prinjha RK, Rioja I, Taylor S, Tomkinson NCO; WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Thomas Graham Building, 259 Cathedral Street, Glasgow G1 1XL, U.K., Wall I, Watson RJ, Woolven J, Demont EH |
| Source: | Journal of medicinal chemistry [J Med Chem] 2021 Aug 12; Vol. 64 (15), pp. 10711-10741. Date of Electronic Publication: 2021 Jul 14. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 34260229 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Lucas+SCC%22">Lucas SCC</searchLink><br /><searchLink fieldCode="AU" term="%22Atkinson+SJ%22">Atkinson SJ</searchLink><br /><searchLink fieldCode="AU" term="%22Chung+CW%22">Chung CW</searchLink><br /><searchLink fieldCode="AU" term="%22Davis+R%22">Davis R</searchLink><br /><searchLink fieldCode="AU" term="%22Gordon+L%22">Gordon L</searchLink><br /><searchLink fieldCode="AU" term="%22Grandi+P%22">Grandi P</searchLink>; IVIVT Cellzome, Platform Technology and Science, GlaxoSmithKline, Meyerhofstrasse 1, 69117 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Gray+JJR%22">Gray JJR</searchLink><br /><searchLink fieldCode="AU" term="%22Grimes+T%22">Grimes T</searchLink><br /><searchLink fieldCode="AU" term="%22Phillipou+A%22">Phillipou A</searchLink><br /><searchLink fieldCode="AU" term="%22Preston+AG%22">Preston AG</searchLink><br /><searchLink fieldCode="AU" term="%22Prinjha+RK%22">Prinjha RK</searchLink><br /><searchLink fieldCode="AU" term="%22Rioja+I%22">Rioja I</searchLink><br /><searchLink fieldCode="AU" term="%22Taylor+S%22">Taylor S</searchLink><br /><searchLink fieldCode="AU" term="%22Tomkinson+NCO%22">Tomkinson NCO</searchLink>; WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Thomas Graham Building, 259 Cathedral Street, Glasgow G1 1XL, U.K.<br /><searchLink fieldCode="AU" term="%22Wall+I%22">Wall I</searchLink><br /><searchLink fieldCode="AU" term="%22Watson+RJ%22">Watson RJ</searchLink><br /><searchLink fieldCode="AU" term="%22Woolven+J%22">Woolven J</searchLink><br /><searchLink fieldCode="AU" term="%22Demont+EH%22">Demont EH</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2021 Aug 12; Vol. 64 (15), pp. 10711-10741. <i>Date of Electronic Publication: </i>2021 Jul 14. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=34260229 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1021/acs.jmedchem.1c00344 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 10711 Titles: – TitleFull: Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lucas SCC – PersonEntity: Name: NameFull: Atkinson SJ – PersonEntity: Name: NameFull: Chung CW – PersonEntity: Name: NameFull: Davis R – PersonEntity: Name: NameFull: Gordon L – PersonEntity: Name: NameFull: Grandi P – PersonEntity: Name: NameFull: Gray JJR – PersonEntity: Name: NameFull: Grimes T – PersonEntity: Name: NameFull: Phillipou A – PersonEntity: Name: NameFull: Preston AG – PersonEntity: Name: NameFull: Prinjha RK – PersonEntity: Name: NameFull: Rioja I – PersonEntity: Name: NameFull: Taylor S – PersonEntity: Name: NameFull: Tomkinson NCO – PersonEntity: Name: NameFull: Wall I – PersonEntity: Name: NameFull: Watson RJ – PersonEntity: Name: NameFull: Woolven J – PersonEntity: Name: NameFull: Demont EH IsPartOfRelationships: – BibEntity: Dates: – D: 12 M: 08 Text: 2021 Aug 12 Type: published Y: 2021 Identifiers: – Type: issn-electronic Value: 1520-4804 Numbering: – Type: volume Value: 64 – Type: issue Value: 15 Titles: – TitleFull: Journal of medicinal chemistry Type: main |
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