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Preclinical in vivo longitudinal assessment of KG207-M as a disease-modifying Alzheimer's disease therapeutic.

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Title: Preclinical in vivo longitudinal assessment of KG207-M as a disease-modifying Alzheimer's disease therapeutic.
Authors: Kang MS; Translational Neuroimaging Laboratory, McGill University Research Centre for Studying in Aging, Montreal, QC, Canada.; Douglas Mental Health University Institute, Montreal, Canada.; McConnell Brain Imaging Centre, McGill University, Montreal, QC, Canada., Shin M; Translational Neuroimaging Laboratory, McGill University Research Centre for Studying in Aging, Montreal, QC, Canada.; Douglas Mental Health University Institute, Montreal, Canada., Ottoy J; Translational Neuroimaging Laboratory, McGill University Research Centre for Studying in Aging, Montreal, QC, Canada., Aliaga AA; Translational Neuroimaging Laboratory, McGill University Research Centre for Studying in Aging, Montreal, QC, Canada.; Douglas Mental Health University Institute, Montreal, Canada.; McConnell Brain Imaging Centre, McGill University, Montreal, QC, Canada., Mathotaarachchi S; Translational Neuroimaging Laboratory, McGill University Research Centre for Studying in Aging, Montreal, QC, Canada.; Douglas Mental Health University Institute, Montreal, Canada., Quispialaya K; Translational Neuroimaging Laboratory, McGill University Research Centre for Studying in Aging, Montreal, QC, Canada., Pascoal TA; Translational Neuroimaging Laboratory, McGill University Research Centre for Studying in Aging, Montreal, QC, Canada.; Douglas Mental Health University Institute, Montreal, Canada., Collins DL; McConnell Brain Imaging Centre, McGill University, Montreal, QC, Canada., Chakravarty MM; Douglas Mental Health University Institute, Montreal, Canada., Mathieu A; Douglas Mental Health University Institute, Montreal, Canada., Sandelius Å; Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden., Blennow K; Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden., Zetterberg H; Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; UK Dementia Research Institute at UCL, London, UK.; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK., Massarweh G; McConnell Brain Imaging Centre, McGill University, Montreal, QC, Canada., Soucy JP; McConnell Brain Imaging Centre, McGill University, Montreal, QC, Canada., Cuello AC; Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada., Gauthier S; Translational Neuroimaging Laboratory, McGill University Research Centre for Studying in Aging, Montreal, QC, Canada.; Douglas Mental Health University Institute, Montreal, Canada.; McConnell Brain Imaging Centre, McGill University, Montreal, QC, Canada., Waterston M; Centre for Imaging Technology Commercialization, London, ON, Canada., Yoganathan N; KalGene Pharmaceuticals Inc., Montreal, Canada., Lessard E; Human Health Therapeutics, National Research Council of Canada, Ottawa, ON, Canada., Haqqani A; Human Health Therapeutics, National Research Council of Canada, Ottawa, ON, Canada., Rennie K; Human Health Therapeutics, National Research Council of Canada, Ottawa, ON, Canada., Stanimirovic D; Human Health Therapeutics, National Research Council of Canada, Ottawa, ON, Canada., Chakravarthy B; Human Health Therapeutics, National Research Council of Canada, Ottawa, ON, Canada., Rosa-Neto P; Translational Neuroimaging Laboratory, McGill University Research Centre for Studying in Aging, Montreal, QC, Canada.; Douglas Mental Health University Institute, Montreal, Canada.; McConnell Brain Imaging Centre, McGill University, Montreal, QC, Canada.
Source: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2022 May; Vol. 42 (5), pp. 788-801. Date of Electronic Publication: 2021 Aug 11.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 8112566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-7016 (Electronic) Linking ISSN: 0271678X NLM ISO Abbreviation: J Cereb Blood Flow Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Preclinical in vivo longitudinal assessment of KG207-M as a disease-modifying Alzheimer's disease therapeutic.
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  Data: <searchLink fieldCode="AU" term="%22Kang+MS%22">Kang MS</searchLink>; Translational Neuroimaging Laboratory, McGill University Research Centre for Studying in Aging, Montreal, QC, Canada.; Douglas Mental Health University Institute, Montreal, Canada.; McConnell Brain Imaging Centre, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Shin+M%22">Shin M</searchLink>; Translational Neuroimaging Laboratory, McGill University Research Centre for Studying in Aging, Montreal, QC, Canada.; Douglas Mental Health University Institute, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Ottoy+J%22">Ottoy J</searchLink>; Translational Neuroimaging Laboratory, McGill University Research Centre for Studying in Aging, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Aliaga+AA%22">Aliaga AA</searchLink>; Translational Neuroimaging Laboratory, McGill University Research Centre for Studying in Aging, Montreal, QC, Canada.; Douglas Mental Health University Institute, Montreal, Canada.; McConnell Brain Imaging Centre, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Mathotaarachchi+S%22">Mathotaarachchi S</searchLink>; Translational Neuroimaging Laboratory, McGill University Research Centre for Studying in Aging, Montreal, QC, Canada.; Douglas Mental Health University Institute, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Quispialaya+K%22">Quispialaya K</searchLink>; Translational Neuroimaging Laboratory, McGill University Research Centre for Studying in Aging, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Pascoal+TA%22">Pascoal TA</searchLink>; Translational Neuroimaging Laboratory, McGill University Research Centre for Studying in Aging, Montreal, QC, Canada.; Douglas Mental Health University Institute, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Collins+DL%22">Collins DL</searchLink>; McConnell Brain Imaging Centre, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Chakravarty+MM%22">Chakravarty MM</searchLink>; Douglas Mental Health University Institute, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Mathieu+A%22">Mathieu A</searchLink>; Douglas Mental Health University Institute, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Sandelius+Å%22">Sandelius Å</searchLink>; Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Blennow+K%22">Blennow K</searchLink>; Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Zetterberg+H%22">Zetterberg H</searchLink>; Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; UK Dementia Research Institute at UCL, London, UK.; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Massarweh+G%22">Massarweh G</searchLink>; McConnell Brain Imaging Centre, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Soucy+JP%22">Soucy JP</searchLink>; McConnell Brain Imaging Centre, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Cuello+AC%22">Cuello AC</searchLink>; Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Gauthier+S%22">Gauthier S</searchLink>; Translational Neuroimaging Laboratory, McGill University Research Centre for Studying in Aging, Montreal, QC, Canada.; Douglas Mental Health University Institute, Montreal, Canada.; McConnell Brain Imaging Centre, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Waterston+M%22">Waterston M</searchLink>; Centre for Imaging Technology Commercialization, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Yoganathan+N%22">Yoganathan N</searchLink>; KalGene Pharmaceuticals Inc., Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Lessard+E%22">Lessard E</searchLink>; Human Health Therapeutics, National Research Council of Canada, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Haqqani+A%22">Haqqani A</searchLink>; Human Health Therapeutics, National Research Council of Canada, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Rennie+K%22">Rennie K</searchLink>; Human Health Therapeutics, National Research Council of Canada, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Stanimirovic+D%22">Stanimirovic D</searchLink>; Human Health Therapeutics, National Research Council of Canada, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Chakravarthy+B%22">Chakravarthy B</searchLink>; Human Health Therapeutics, National Research Council of Canada, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Rosa-Neto+P%22">Rosa-Neto P</searchLink>; Translational Neuroimaging Laboratory, McGill University Research Centre for Studying in Aging, Montreal, QC, Canada.; Douglas Mental Health University Institute, Montreal, Canada.; McConnell Brain Imaging Centre, McGill University, Montreal, QC, Canada.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22SAGE+Publications%22">SAGE Publications </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8112566 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1559-7016 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220271678X%22">0271678X </searchLink><i>NLM ISO Abbreviation: </i>J Cereb Blood Flow Metab <i>Subsets: </i>MEDLINE
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