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Immunotherapy combinations overcome resistance to bispecific T cell engager treatment in T cell-cold solid tumors.

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Title: Immunotherapy combinations overcome resistance to bispecific T cell engager treatment in T cell-cold solid tumors.
Authors: Belmontes B; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, Thousand Oaks, CA 91320, USA., Sawant DV; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA., Zhong W; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA., Tan H; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, Thousand Oaks, CA 91320, USA., Kaul A; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA., Aeffner F; Amgen Research, Thousand Oaks, CA 91320, USA.; Translational Safety and Bioanalytical Sciences, Amgen, South San Francisco, CA 94080, USA., O'Brien SA; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA., Chun M; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA., Noubade R; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA., Eng J; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA., Ma H; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, Thousand Oaks, CA 91320, USA., Muenz M; Amgen Research, Thousand Oaks, CA 91320, USA.; Amgen Research GmbH, Munich 81477, Germany., Li P; Amgen Research, Thousand Oaks, CA 91320, USA.; Therapeutic Discovery, Amgen, South San Francisco, CA 94080, USA., Alba BM; Amgen Research, Thousand Oaks, CA 91320, USA.; Therapeutic Discovery, Amgen, South San Francisco, CA 94080, USA., Thomas M; Amgen Research, Thousand Oaks, CA 91320, USA.; Therapeutic Discovery, Amgen, South San Francisco, CA 94080, USA., Cook K; Amgen Research, Thousand Oaks, CA 91320, USA.; Pharmacokinetics and Drug Metabolism, Amgen, South San Francisco, CA 94080, USA., Wang X; Amgen Research, Thousand Oaks, CA 91320, USA.; Translational Safety and Bioanalytical Sciences, Amgen, South San Francisco, CA 94080, USA., DeVoss J; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA., Egen JG; Amgen Research, Thousand Oaks, CA 91320, USA. oliviern@amgen.com Jackson.egen@gmail.com.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA., Nolan-Stevaux O; Amgen Research, Thousand Oaks, CA 91320, USA. oliviern@amgen.com Jackson.egen@gmail.com.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA.
Source: Science translational medicine [Sci Transl Med] 2021 Aug 25; Vol. 13 (608).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Immunotherapy combinations overcome resistance to bispecific T cell engager treatment in T cell-cold solid tumors.
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  Data: <searchLink fieldCode="AU" term="%22Belmontes+B%22">Belmontes B</searchLink>; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, Thousand Oaks, CA 91320, USA.<br /><searchLink fieldCode="AU" term="%22Sawant+DV%22">Sawant DV</searchLink>; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Zhong+W%22">Zhong W</searchLink>; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Tan+H%22">Tan H</searchLink>; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, Thousand Oaks, CA 91320, USA.<br /><searchLink fieldCode="AU" term="%22Kaul+A%22">Kaul A</searchLink>; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Aeffner+F%22">Aeffner F</searchLink>; Amgen Research, Thousand Oaks, CA 91320, USA.; Translational Safety and Bioanalytical Sciences, Amgen, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22O'Brien+SA%22">O'Brien SA</searchLink>; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Chun+M%22">Chun M</searchLink>; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Noubade+R%22">Noubade R</searchLink>; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Eng+J%22">Eng J</searchLink>; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Ma+H%22">Ma H</searchLink>; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, Thousand Oaks, CA 91320, USA.<br /><searchLink fieldCode="AU" term="%22Muenz+M%22">Muenz M</searchLink>; Amgen Research, Thousand Oaks, CA 91320, USA.; Amgen Research GmbH, Munich 81477, Germany.<br /><searchLink fieldCode="AU" term="%22Li+P%22">Li P</searchLink>; Amgen Research, Thousand Oaks, CA 91320, USA.; Therapeutic Discovery, Amgen, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Alba+BM%22">Alba BM</searchLink>; Amgen Research, Thousand Oaks, CA 91320, USA.; Therapeutic Discovery, Amgen, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Thomas+M%22">Thomas M</searchLink>; Amgen Research, Thousand Oaks, CA 91320, USA.; Therapeutic Discovery, Amgen, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Cook+K%22">Cook K</searchLink>; Amgen Research, Thousand Oaks, CA 91320, USA.; Pharmacokinetics and Drug Metabolism, Amgen, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Amgen Research, Thousand Oaks, CA 91320, USA.; Translational Safety and Bioanalytical Sciences, Amgen, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22DeVoss+J%22">DeVoss J</searchLink>; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Egen+JG%22">Egen JG</searchLink>; Amgen Research, Thousand Oaks, CA 91320, USA. oliviern@amgen.com Jackson.egen@gmail.com.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Nolan-Stevaux+O%22">Nolan-Stevaux O</searchLink>; Amgen Research, Thousand Oaks, CA 91320, USA. oliviern@amgen.com Jackson.egen@gmail.com.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2021 Aug 25; Vol. 13 (608).
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        Value: 10.1126/scitranslmed.abd1524
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