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Murine cancer cachexia models replicate elevated catabolic pembrolizumab clearance in humans.

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Title: Murine cancer cachexia models replicate elevated catabolic pembrolizumab clearance in humans.
Authors: Castillo AMM; Division of Pharmaceutics and Pharmacology, College of Pharmacy The Ohio State University Columbus OH USA., Vu TT; Division of Pharmaceutics and Pharmacology, College of Pharmacy The Ohio State University Columbus OH USA., Liva SG; Division of Pharmaceutics and Pharmacology, College of Pharmacy The Ohio State University Columbus OH USA., Chen M; Division of Pharmaceutics and Pharmacology, College of Pharmacy The Ohio State University Columbus OH USA., Xie Z; Division of Pharmaceutics and Pharmacology, College of Pharmacy The Ohio State University Columbus OH USA., Thomas J; Division of Pharmaceutics and Pharmacology, College of Pharmacy The Ohio State University Columbus OH USA., Remaily B; Division of Pharmaceutics and Pharmacology, College of Pharmacy The Ohio State University Columbus OH USA., Guo Y; Division of Pharmaceutics and Pharmacology, College of Pharmacy The Ohio State University Columbus OH USA., Subrayan UL; Division of Pharmaceutics and Pharmacology, College of Pharmacy The Ohio State University Columbus OH USA., Costa T; Department of Biomedical Engineering, College of Engineering The Ohio State University Columbus OH USA., Helms TH; Department of Veterinary Biosciences, College of Veterinary Medicine The Ohio State University Columbus OH USA., Irby DJ; Division of Pharmaceutics and Pharmacology, College of Pharmacy The Ohio State University Columbus OH USA., Kim K; Division of Pharmaceutics and Pharmacology, College of Pharmacy The Ohio State University Columbus OH USA., Owen DH; Division of Medical Oncology The Ohio State University James Comprehensive Cancer Center Columbus OH USA., Kulp SK; Division of Pharmaceutics and Pharmacology, College of Pharmacy The Ohio State University Columbus OH USA., Mace TA; Division of Gastroenterology, Hepatology & Nutrition, Department of Medicine The Ohio State University Columbus OH USA.; The Comprehensive Cancer Center The Ohio State University Columbus OH 43210 USA., Phelps MA; Division of Pharmaceutics and Pharmacology, College of Pharmacy The Ohio State University Columbus OH USA.; The Comprehensive Cancer Center The Ohio State University Columbus OH 43210 USA., Coss CC; Division of Pharmaceutics and Pharmacology, College of Pharmacy The Ohio State University Columbus OH USA.; The Comprehensive Cancer Center The Ohio State University Columbus OH 43210 USA.
Source: JCSM rapid communications [JCSM Rapid Commun] 2021 Jul-Dec; Vol. 4 (2), pp. 232-244. Date of Electronic Publication: 2021 Feb 09.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101726459 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2617-1619 (Electronic) Linking ISSN: 26171619 NLM ISO Abbreviation: JCSM Rapid Commun Subsets: PubMed not MEDLINE
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