SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria.
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| Title: | SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria. |
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| Authors: | Xue Y; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.; Department of Human Genetics, McGill University, Montreal, QC, Canada.; Division of Medical Genetics, McGill University Health Centre, and Cancer Research Program, Research Institute of the McGill University Health Centre, McGill University, Montreal, QC, Canada., Morris JL; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Yang K; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada., Fu Z; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada., Zhu X; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada., Johnson F; Department of Integrative Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada.; Interdisciplinary Oncology Program, University of British Columbia, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada., Meehan B; Department of Pediatrics, Research Institute of the McGill University Health Centre, Montreal Children's Hospital, McGill University, Montreal, QC, Canada., Witkowski L; Department of Human Genetics, McGill University, Montreal, QC, Canada.; Department of Specialized Medicine, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC, Canada., Yasmeen A; Division of Gynecologic Oncology, Segal Cancer Center, Jewish General Hospital, McGill University, Montreal, QC, Canada., Golenar T; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada., Coatham M; Department of Oncology, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, AB, Canada., Morin G; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada., Monast A; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada., Pilon V; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada., Fiset PO; Department of Pathology, McGill University Health Centre, Montreal, QC, Canada., Jung S; Department of Pathology, McGill University Health Centre, Montreal, QC, Canada., Gonzalez AV; Department of Medicine, Division of Respiratory Medicine, McGill University Health Centre, Montreal Chest Institute, Montreal, QC, Canada., Camilleri-Broet S; Department of Pathology, McGill University Health Centre, Montreal, QC, Canada., Fu L; Department of Pathology, McGill University Health Centre, Montreal, QC, Canada., Postovit LM; Department of Oncology, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, AB, Canada.; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada., Spicer J; Department of Surgery, McGill University Health Center, Montreal, QC, Canada., Gotlieb WH; Division of Gynecologic Oncology, Segal Cancer Center, Jewish General Hospital, McGill University, Montreal, QC, Canada., Guiot MC; Department of Pathology, Montreal Neurological Hospital/Institute, McGill University Health Centre, Montreal, QC, Canada., Rak J; Department of Pediatrics, Research Institute of the McGill University Health Centre, Montreal Children's Hospital, McGill University, Montreal, QC, Canada., Park M; Department of Biochemistry, McGill University, Montreal, QC, Canada.; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada., Lockwood W; Department of Integrative Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada.; Interdisciplinary Oncology Program, University of British Columbia, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada., Foulkes WD; Department of Human Genetics, McGill University, Montreal, QC, Canada.; Division of Medical Genetics, McGill University Health Centre, and Cancer Research Program, Research Institute of the McGill University Health Centre, McGill University, Montreal, QC, Canada.; Department of Specialized Medicine, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC, Canada., Prudent J; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK. julien.prudent@mrc-mbu.cam.ac.uk., Huang S; Department of Biochemistry, McGill University, Montreal, QC, Canada. sidong.huang@mcgill.ca.; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada. sidong.huang@mcgill.ca. |
| Source: | Nature communications [Nat Commun] 2021 Sep 13; Vol. 12 (1), pp. 5404. Date of Electronic Publication: 2021 Sep 13. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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