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Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy.

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Title: Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy.
Authors: Krieger TG; Digital Health Center, Berlin Institute of Health (BIH)/Charité-Universitätsmedizin Berlin, Berlin, Germany.; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Le Blanc S; European Pancreas Center, Department of General Surgery, Heidelberg University Hospital, Heidelberg, Germany.; Division of Molecular Oncology of Gastrointestinal Tumors, German Cancer Research Center (DKFZ), Heidelberg, Germany.; National Center for Tumor diseases (NCT), Heidelberg, Germany., Jabs J; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Ten FW; Digital Health Center, Berlin Institute of Health (BIH)/Charité-Universitätsmedizin Berlin, Berlin, Germany.; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Ishaque N; Digital Health Center, Berlin Institute of Health (BIH)/Charité-Universitätsmedizin Berlin, Berlin, Germany., Jechow K; Digital Health Center, Berlin Institute of Health (BIH)/Charité-Universitätsmedizin Berlin, Berlin, Germany.; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Debnath O; Digital Health Center, Berlin Institute of Health (BIH)/Charité-Universitätsmedizin Berlin, Berlin, Germany., Leonhardt CS; European Pancreas Center, Department of General Surgery, Heidelberg University Hospital, Heidelberg, Germany., Giri A; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Eils R; Digital Health Center, Berlin Institute of Health (BIH)/Charité-Universitätsmedizin Berlin, Berlin, Germany. roland.eils@charite.de.; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany. roland.eils@charite.de., Strobel O; European Pancreas Center, Department of General Surgery, Heidelberg University Hospital, Heidelberg, Germany. oliver.strobel@meduniwien.ac.at.; National Center for Tumor diseases (NCT), Heidelberg, Germany. oliver.strobel@meduniwien.ac.at.; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria. oliver.strobel@meduniwien.ac.at., Conrad C; Digital Health Center, Berlin Institute of Health (BIH)/Charité-Universitätsmedizin Berlin, Berlin, Germany. christian.conrad@charite.de.; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany. christian.conrad@charite.de.
Source: Nature communications [Nat Commun] 2021 Oct 05; Vol. 12 (1), pp. 5826. Date of Electronic Publication: 2021 Oct 05.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy.
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  Data: <searchLink fieldCode="AU" term="%22Krieger+TG%22">Krieger TG</searchLink>; Digital Health Center, Berlin Institute of Health (BIH)/Charité-Universitätsmedizin Berlin, Berlin, Germany.; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Le+Blanc+S%22">Le Blanc S</searchLink>; European Pancreas Center, Department of General Surgery, Heidelberg University Hospital, Heidelberg, Germany.; Division of Molecular Oncology of Gastrointestinal Tumors, German Cancer Research Center (DKFZ), Heidelberg, Germany.; National Center for Tumor diseases (NCT), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Jabs+J%22">Jabs J</searchLink>; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Ten+FW%22">Ten FW</searchLink>; Digital Health Center, Berlin Institute of Health (BIH)/Charité-Universitätsmedizin Berlin, Berlin, Germany.; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Ishaque+N%22">Ishaque N</searchLink>; Digital Health Center, Berlin Institute of Health (BIH)/Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Jechow+K%22">Jechow K</searchLink>; Digital Health Center, Berlin Institute of Health (BIH)/Charité-Universitätsmedizin Berlin, Berlin, Germany.; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Debnath+O%22">Debnath O</searchLink>; Digital Health Center, Berlin Institute of Health (BIH)/Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Leonhardt+CS%22">Leonhardt CS</searchLink>; European Pancreas Center, Department of General Surgery, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Giri+A%22">Giri A</searchLink>; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Eils+R%22">Eils R</searchLink>; Digital Health Center, Berlin Institute of Health (BIH)/Charité-Universitätsmedizin Berlin, Berlin, Germany. roland.eils@charite.de.; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany. roland.eils@charite.de.<br /><searchLink fieldCode="AU" term="%22Strobel+O%22">Strobel O</searchLink>; European Pancreas Center, Department of General Surgery, Heidelberg University Hospital, Heidelberg, Germany. oliver.strobel@meduniwien.ac.at.; National Center for Tumor diseases (NCT), Heidelberg, Germany. oliver.strobel@meduniwien.ac.at.; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria. oliver.strobel@meduniwien.ac.at.<br /><searchLink fieldCode="AU" term="%22Conrad+C%22">Conrad C</searchLink>; Digital Health Center, Berlin Institute of Health (BIH)/Charité-Universitätsmedizin Berlin, Berlin, Germany. christian.conrad@charite.de.; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany. christian.conrad@charite.de.
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