Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy.
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| Title: | Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy. |
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| Authors: | Krieger TG; Digital Health Center, Berlin Institute of Health (BIH)/Charité-Universitätsmedizin Berlin, Berlin, Germany.; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Le Blanc S; European Pancreas Center, Department of General Surgery, Heidelberg University Hospital, Heidelberg, Germany.; Division of Molecular Oncology of Gastrointestinal Tumors, German Cancer Research Center (DKFZ), Heidelberg, Germany.; National Center for Tumor diseases (NCT), Heidelberg, Germany., Jabs J; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Ten FW; Digital Health Center, Berlin Institute of Health (BIH)/Charité-Universitätsmedizin Berlin, Berlin, Germany.; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Ishaque N; Digital Health Center, Berlin Institute of Health (BIH)/Charité-Universitätsmedizin Berlin, Berlin, Germany., Jechow K; Digital Health Center, Berlin Institute of Health (BIH)/Charité-Universitätsmedizin Berlin, Berlin, Germany.; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Debnath O; Digital Health Center, Berlin Institute of Health (BIH)/Charité-Universitätsmedizin Berlin, Berlin, Germany., Leonhardt CS; European Pancreas Center, Department of General Surgery, Heidelberg University Hospital, Heidelberg, Germany., Giri A; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Eils R; Digital Health Center, Berlin Institute of Health (BIH)/Charité-Universitätsmedizin Berlin, Berlin, Germany. roland.eils@charite.de.; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany. roland.eils@charite.de., Strobel O; European Pancreas Center, Department of General Surgery, Heidelberg University Hospital, Heidelberg, Germany. oliver.strobel@meduniwien.ac.at.; National Center for Tumor diseases (NCT), Heidelberg, Germany. oliver.strobel@meduniwien.ac.at.; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria. oliver.strobel@meduniwien.ac.at., Conrad C; Digital Health Center, Berlin Institute of Health (BIH)/Charité-Universitätsmedizin Berlin, Berlin, Germany. christian.conrad@charite.de.; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany. christian.conrad@charite.de. |
| Source: | Nature communications [Nat Commun] 2021 Oct 05; Vol. 12 (1), pp. 5826. Date of Electronic Publication: 2021 Oct 05. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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