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Uncovering a conserved vulnerability site in SARS-CoV-2 by a human antibody.

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Title: Uncovering a conserved vulnerability site in SARS-CoV-2 by a human antibody.
Authors: Li T; State Key Laboratory of Molecular Biology, State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.; University of CAS, Beijing, China., Cai H; State Key Laboratory of Molecular Biology, State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.; University of CAS, Beijing, China., Zhao Y; University of CAS, Beijing, China.; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai CAS, Shanghai, China., Li Y; State Key Laboratory of Molecular Biology, State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.; University of CAS, Beijing, China., Lai Y; State Key Laboratory of Molecular Biology, State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.; University of CAS, Beijing, China., Yao H; State Key Laboratory of Molecular Biology, State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.; University of CAS, Beijing, China., Liu LD; State Key Laboratory of Molecular Biology, State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.; University of CAS, Beijing, China., Sun Z; Hangzhou Center for Disease Control and Prevention, Hangzhou, China., van Vlissingen MF; Erasmus Laboratory Animal Science Center, Erasmus University Medical Center, Rotterdam, The Netherlands.; European Research Infrastructure on Highly Pathogenic Agents (ERINHA-AISBL), Paris, France., Kuiken T; European Research Infrastructure on Highly Pathogenic Agents (ERINHA-AISBL), Paris, France.; Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands., GeurtsvanKessel CH; European Research Infrastructure on Highly Pathogenic Agents (ERINHA-AISBL), Paris, France.; Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands., Zhang N; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), CAS, Beijing, China., Zhou B; University of CAS, Beijing, China.; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai CAS, Shanghai, China., Lu L; University of CAS, Beijing, China.; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai CAS, Shanghai, China., Gong Y; University of CAS, Beijing, China.; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), CAS, Beijing, China., Qin W; National Facility for Protein Science in Shanghai, Shanghai Advanced Research Institute (Zhangjiang Laboratory), CAS, Shanghai, China., Mondal M; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai CAS, Shanghai, China.; Joint Center for Infection and Immunity, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Duan B; University of CAS, Beijing, China.; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai CAS, Shanghai, China., Xu S; University of CAS, Beijing, China.; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai CAS, Shanghai, China., Richard AS; European Research Infrastructure on Highly Pathogenic Agents (ERINHA-AISBL), Paris, France., Raoul H; European Research Infrastructure on Highly Pathogenic Agents (ERINHA-AISBL), Paris, France., Chen J; State Key Laboratory of Molecular Biology, State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China., Xu C; State Key Laboratory of Molecular Biology, State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China., Wu L; State Key Laboratory of Molecular Biology, State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China., Zhou H; State Key Laboratory of Molecular Biology, State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.; University of CAS, Beijing, China., Huang Z; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai CAS, Shanghai, China.; Joint Center for Infection and Immunity, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Zhang X; Hangzhou Center for Disease Control and Prevention, Hangzhou, China., Li J; Hangzhou Center for Disease Control and Prevention, Hangzhou, China., Wang Y; State Key Laboratory of Molecular Biology, State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.; University of CAS, Beijing, China., Bi Y; University of CAS, Beijing, China.; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), CAS, Beijing, China., Rockx B; European Research Infrastructure on Highly Pathogenic Agents (ERINHA-AISBL), Paris, France.; Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands., Chen J; Hangzhou Center for Disease Control and Prevention, Hangzhou, China., Meng FL; State Key Laboratory of Molecular Biology, State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.; University of CAS, Beijing, China., Lavillette D; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai CAS, Shanghai, China.; Joint Center for Infection and Immunity, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.; Pasteurien College, Soochow University, Jiangsu, China., Li D; State Key Laboratory of Molecular Biology, State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.
Source: EMBO molecular medicine [EMBO Mol Med] 2021 Dec 07; Vol. 13 (12), pp. e14544. Date of Electronic Publication: 2021 Nov 17.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Uncovering a conserved vulnerability site in SARS-CoV-2 by a human antibody.
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  Data: <searchLink fieldCode="AU" term="%22Li+T%22">Li T</searchLink>; State Key Laboratory of Molecular Biology, State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.; University of CAS, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Cai+H%22">Cai H</searchLink>; State Key Laboratory of Molecular Biology, State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.; University of CAS, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; University of CAS, Beijing, China.; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai CAS, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; State Key Laboratory of Molecular Biology, State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.; University of CAS, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Lai+Y%22">Lai Y</searchLink>; State Key Laboratory of Molecular Biology, State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.; University of CAS, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Yao+H%22">Yao H</searchLink>; State Key Laboratory of Molecular Biology, State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.; University of CAS, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Liu+LD%22">Liu LD</searchLink>; State Key Laboratory of Molecular Biology, State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.; 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CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), CAS, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhou+B%22">Zhou B</searchLink>; University of CAS, Beijing, China.; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai CAS, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Lu+L%22">Lu L</searchLink>; University of CAS, Beijing, China.; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai CAS, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Gong+Y%22">Gong Y</searchLink>; University of CAS, Beijing, China.; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), CAS, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Qin+W%22">Qin W</searchLink>; National Facility for Protein Science in Shanghai, Shanghai Advanced Research Institute (Zhangjiang Laboratory), CAS, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Mondal+M%22">Mondal M</searchLink>; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai CAS, Shanghai, China.; Joint Center for Infection and Immunity, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Duan+B%22">Duan B</searchLink>; University of CAS, Beijing, China.; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai CAS, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Xu+S%22">Xu S</searchLink>; University of CAS, Beijing, China.; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai CAS, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Richard+AS%22">Richard AS</searchLink>; European Research Infrastructure on Highly Pathogenic Agents (ERINHA-AISBL), Paris, France.<br /><searchLink fieldCode="AU" term="%22Raoul+H%22">Raoul H</searchLink>; European Research Infrastructure on Highly Pathogenic Agents (ERINHA-AISBL), Paris, France.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; State Key Laboratory of Molecular Biology, State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Xu+C%22">Xu C</searchLink>; State Key Laboratory of Molecular Biology, State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wu+L%22">Wu L</searchLink>; State Key Laboratory of Molecular Biology, State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhou+H%22">Zhou H</searchLink>; State Key Laboratory of Molecular Biology, State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.; University of CAS, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Huang+Z%22">Huang Z</searchLink>; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai CAS, Shanghai, China.; Joint Center for Infection and Immunity, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Hangzhou Center for Disease Control and Prevention, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Hangzhou Center for Disease Control and Prevention, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; State Key Laboratory of Molecular Biology, State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China.; 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