Genetic and functional evidence links a missense variant in B4GALT1 to lower LDL and fibrinogen.
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| Title: | Genetic and functional evidence links a missense variant in B4GALT1 to lower LDL and fibrinogen. |
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| Authors: | Montasser ME; Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Van Hout CV; Regeneron Genetics Center, LLC, Tarrytown, NY 10591, USA.; Laboratorio Internacional de Investigatión sobre el Genoma Humano, Campus Juriquilla de la Universidad Nacional Autónoma de México, Querétaro, Querétaro 76230, México., Miloscio L; Regeneron Genetics Center, LLC, Tarrytown, NY 10591, USA., Howard AD; Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.; Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993, USA., Rosenberg A; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Callaway M; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Shen B; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Li N; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Locke AE; Regeneron Genetics Center, LLC, Tarrytown, NY 10591, USA., Verweij N; Regeneron Genetics Center, LLC, Tarrytown, NY 10591, USA., De T; Regeneron Genetics Center, LLC, Tarrytown, NY 10591, USA., Ferreira MA; Regeneron Genetics Center, LLC, Tarrytown, NY 10591, USA., Lotta LA; Regeneron Genetics Center, LLC, Tarrytown, NY 10591, USA., Baras A; Regeneron Genetics Center, LLC, Tarrytown, NY 10591, USA., Daly TJ; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Hartford SA; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Lin W; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Mao Y; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Ye B; Regeneron Genetics Center, LLC, Tarrytown, NY 10591, USA., White D; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Gong G; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Perry JA; Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Ryan KA; Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Fang Q; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Tzoneva G; Regeneron Genetics Center, LLC, Tarrytown, NY 10591, USA., Pefanis E; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Hunt C; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Tang Y; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Lee L; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Sztalryd-Woodle C; Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.; US Department of Veterans Affairs, Washington, DC 20420 USA., Mitchell BD; Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.; Geriatrics Research and Education Clinical Center, VA Medical Center, Baltimore, MD 21201, USA., Healy M; Enveda Biosciences, Boulder, CO 80301, USA., Streeten EA; Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.; Division of Genetics, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Taylor SI; Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA., O'Connell JR; Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Economides AN; Regeneron Genetics Center, LLC, Tarrytown, NY 10591, USA.; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Della Gatta G; Regeneron Genetics Center, LLC, Tarrytown, NY 10591, USA., Shuldiner AR; Regeneron Genetics Center, LLC, Tarrytown, NY 10591, USA. |
| Corporate Authors: | Regeneron Genetics Center Collaboration‡ |
| Source: | Science (New York, N.Y.) [Science] 2021 Dec 03; Vol. 374 (6572), pp. 1221-1227. Date of Electronic Publication: 2021 Dec 02. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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