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Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2.

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Title: Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2.
Authors: Hatton CF; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Botting RA; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Dueñas ME; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Haq IJ; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Paediatric Respiratory Medicine, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Verdon B; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Thompson BJ; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Spegarova JS; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Gothe F; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany., Stephenson E; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Gardner AI; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Murphy S; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Scott J; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Garnett JP; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Carrie S; Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK., Powell J; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Khan CMA; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Huang L; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Hussain R; Genomics Core Facility, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Coxhead J; Genomics Core Facility, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Davey T; Electron Microscopy Research Services, Newcastle University, Newcastle upon Tyne, UK., Simpson AJ; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Haniffa M; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.; NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.; Department of Dermatology, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Hambleton S; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Brodlie M; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Paediatric Respiratory Medicine, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Ward C; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Trost M; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Reynolds G; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Duncan CJA; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK. christopher.duncan@ncl.ac.uk.; Department of Infection and Tropical Medicine, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. christopher.duncan@ncl.ac.uk.
Source: Nature communications [Nat Commun] 2021 Dec 07; Vol. 12 (1), pp. 7092. Date of Electronic Publication: 2021 Dec 07.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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